Functional non-glutaraldehyde treated porcine pericardium for anti-coagulation, anti-calcification, and endothelial proliferation bioprosthetic heart valves
Abstract In the last decade, the number of transcatheter heart valve replacement for severe heart valve disease has increased exponentially. Although the bioprosthetic artificial heart valve (BHV) has similar fluid dynamics performance to the original heart valve compared with mechanical heart valve...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-08-01
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| Series: | Journal of Leather Science and Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42825-022-00098-z |
| _version_ | 1797831887263105024 |
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| author | Xiaotong Chen Tao Yu Qunshou Kong Dajun Kuang Hong Xu Zhiyu Zhao Li Yang Gaocan Li Haojun Fan Yunbing Wang |
| author_facet | Xiaotong Chen Tao Yu Qunshou Kong Dajun Kuang Hong Xu Zhiyu Zhao Li Yang Gaocan Li Haojun Fan Yunbing Wang |
| author_sort | Xiaotong Chen |
| collection | DOAJ |
| description | Abstract In the last decade, the number of transcatheter heart valve replacement for severe heart valve disease has increased exponentially. Although the bioprosthetic artificial heart valve (BHV) has similar fluid dynamics performance to the original heart valve compared with mechanical heart valve so that there is no need to take long-term anticoagulant drugs to prevent thromboembolism, transcatheter BHV replacement are still at risk for thrombosis during the first few months according to the clinical data. However, the use of antithrombotic drugs can also increase the risk of bleeding. Therefore, it is particularly important to improve the anticoagulant properties for the BHV itself. In this work, a kind of non-glutaraldehyde cross-linked BHV material with excellent antithrombotic ability has been prepared from carboxylated oxazolidine treated porcine pericardium (consisting of collagen, elastin and glycoprotein) with the further graft of the anticoagulant heparin sodium via hydrophilic modified chitosan. Along with the similar mechanical properties and collagen stability comparable to the glutaraldehyde cross-linked porcine pericardium (PP), these functional non-glutaraldehyde cross-linked PPs exhibit better biocompatibility, promoted endothelial proliferation and superior anti-calcification ability. More importantly, excellent anticoagulant activity can be observed in the hematological experiments in vivo and in vitro. In summary, these excellent performances make these functional non-glutaraldehyde cross-linked PPs great potentialities in the BHV applications. Graphical abstract |
| first_indexed | 2024-04-09T13:59:59Z |
| format | Article |
| id | doaj.art-68dda8c0db334d47b6e707d07138a263 |
| institution | Directory Open Access Journal |
| issn | 2524-7859 |
| language | English |
| last_indexed | 2024-04-09T13:59:59Z |
| publishDate | 2022-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Leather Science and Engineering |
| spelling | doaj.art-68dda8c0db334d47b6e707d07138a2632023-05-07T11:24:00ZengSpringerOpenJournal of Leather Science and Engineering2524-78592022-08-014111310.1186/s42825-022-00098-zFunctional non-glutaraldehyde treated porcine pericardium for anti-coagulation, anti-calcification, and endothelial proliferation bioprosthetic heart valvesXiaotong Chen0Tao Yu1Qunshou Kong2Dajun Kuang3Hong Xu4Zhiyu Zhao5Li Yang6Gaocan Li7Haojun Fan8Yunbing Wang9National Engineering Research Center of Clean Technology in Leather Industry, Sichuan UniversityNational Engineering Research Center for Biomaterials, Sichuan UniversityNational Engineering Research Center for Biomaterials, Sichuan UniversityVenus Medtech (Hangzhou) Inc.National Engineering Research Center for Biomaterials, Sichuan UniversityNational Engineering Research Center for Biomaterials, Sichuan UniversityNational Engineering Research Center for Biomaterials, Sichuan UniversityNational Engineering Research Center for Biomaterials, Sichuan UniversityNational Engineering Research Center of Clean Technology in Leather Industry, Sichuan UniversityNational Engineering Research Center for Biomaterials, Sichuan UniversityAbstract In the last decade, the number of transcatheter heart valve replacement for severe heart valve disease has increased exponentially. Although the bioprosthetic artificial heart valve (BHV) has similar fluid dynamics performance to the original heart valve compared with mechanical heart valve so that there is no need to take long-term anticoagulant drugs to prevent thromboembolism, transcatheter BHV replacement are still at risk for thrombosis during the first few months according to the clinical data. However, the use of antithrombotic drugs can also increase the risk of bleeding. Therefore, it is particularly important to improve the anticoagulant properties for the BHV itself. In this work, a kind of non-glutaraldehyde cross-linked BHV material with excellent antithrombotic ability has been prepared from carboxylated oxazolidine treated porcine pericardium (consisting of collagen, elastin and glycoprotein) with the further graft of the anticoagulant heparin sodium via hydrophilic modified chitosan. Along with the similar mechanical properties and collagen stability comparable to the glutaraldehyde cross-linked porcine pericardium (PP), these functional non-glutaraldehyde cross-linked PPs exhibit better biocompatibility, promoted endothelial proliferation and superior anti-calcification ability. More importantly, excellent anticoagulant activity can be observed in the hematological experiments in vivo and in vitro. In summary, these excellent performances make these functional non-glutaraldehyde cross-linked PPs great potentialities in the BHV applications. Graphical abstracthttps://doi.org/10.1186/s42825-022-00098-zBioprosthetic heart valvesOxazolidineCytocompatibilityAnti-coagulation |
| spellingShingle | Xiaotong Chen Tao Yu Qunshou Kong Dajun Kuang Hong Xu Zhiyu Zhao Li Yang Gaocan Li Haojun Fan Yunbing Wang Functional non-glutaraldehyde treated porcine pericardium for anti-coagulation, anti-calcification, and endothelial proliferation bioprosthetic heart valves Journal of Leather Science and Engineering Bioprosthetic heart valves Oxazolidine Cytocompatibility Anti-coagulation |
| title | Functional non-glutaraldehyde treated porcine pericardium for anti-coagulation, anti-calcification, and endothelial proliferation bioprosthetic heart valves |
| title_full | Functional non-glutaraldehyde treated porcine pericardium for anti-coagulation, anti-calcification, and endothelial proliferation bioprosthetic heart valves |
| title_fullStr | Functional non-glutaraldehyde treated porcine pericardium for anti-coagulation, anti-calcification, and endothelial proliferation bioprosthetic heart valves |
| title_full_unstemmed | Functional non-glutaraldehyde treated porcine pericardium for anti-coagulation, anti-calcification, and endothelial proliferation bioprosthetic heart valves |
| title_short | Functional non-glutaraldehyde treated porcine pericardium for anti-coagulation, anti-calcification, and endothelial proliferation bioprosthetic heart valves |
| title_sort | functional non glutaraldehyde treated porcine pericardium for anti coagulation anti calcification and endothelial proliferation bioprosthetic heart valves |
| topic | Bioprosthetic heart valves Oxazolidine Cytocompatibility Anti-coagulation |
| url | https://doi.org/10.1186/s42825-022-00098-z |
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