Protocol for the Psychosis Immune Mechanism Stratified Medicine (PIMS) trial: a randomised double-blind placebo-controlled trial of single-dose tocilizumab in patients with psychosis

Protocol for the Psychosis Immune Mechanism Stratified Medicine (PIMS) trial: a randomised double-blind placebo-controlled trial of single-dose tocilizumab in patients with psychosis

Introduction Evidence suggests a potentially causal role of interleukin 6 (IL-6), a pleiotropic cytokine that generally promotes inflammation, in the pathogenesis of psychosis. However, no interventional studies in patients with psychosis, stratified using inflammatory markers, have been conducted t...

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Main Authors: Stephen Burgess, Peter Jones, Rachel Upthegrove, Carmine Pariante, Graham K Murray, Anthony David, Martin Wilson, Nicholas Barnes, Paola Dazzan, John Suckling, Valeria Mondelli, Muzaffer Kaser, Neil Harrison, Georgios Gkoutos, Golam M Khandaker, Deepak Jadon, James MacCabe, Gary Donohoe, Alice Egerton, Bill Deakin, Jack Rogers, Éimear M Foley, Sian Lowri Griffiths, Alexander Murray, Fabiana Corsi-Zuelli, Hannah Hickinbotham, Ella Warwick, Nicholas M Barnes, Golam Khandaker, David Cotter, Ed Bullmore, Eva Meisenzahl, Joanna Neill, Nikos Koutsouleris, Stephen Wood
Format: Article
Language:English
Published: BMJ Publishing Group 2023-03-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/13/3/e067944.full

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