Giant cell arteritis: is the clinical spectrum of the disease changing?
Abstract Background Giant cell arteritis is a vasculitis of large and middle-sized arteries that affects patients aged over 50 years. It can show a typical clinical picture consisting of cranial manifestations but sometimes nonspecific symptoms and large-vessel involvement prevail. Prompt diagnosis...
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| Format: | Article |
| Language: | English |
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BMC
2019-07-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12877-019-1225-9 |
| _version_ | 1828481440085442560 |
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| author | Miguel Á. González-Gay Miguel Ortego-Jurado Liliana Ercole Norberto Ortego-Centeno |
| author_facet | Miguel Á. González-Gay Miguel Ortego-Jurado Liliana Ercole Norberto Ortego-Centeno |
| author_sort | Miguel Á. González-Gay |
| collection | DOAJ |
| description | Abstract Background Giant cell arteritis is a vasculitis of large and middle-sized arteries that affects patients aged over 50 years. It can show a typical clinical picture consisting of cranial manifestations but sometimes nonspecific symptoms and large-vessel involvement prevail. Prompt diagnosis and treatment is essential to avoid irreversible damage. Discussion There has been an increasing knowledge on the occurrence of the disease without the typical cranial symptoms and its close relationship and overlap with polymyalgia rheumatica, and this may contribute to reduce the number of underdiagnosed patients. Although temporal artery biopsy is still the gold-standard and temporal artery ultrasonography is being widely used, newer imaging techniques (FDG-PET/TAC, MRI, CT) can be of valuable help to identify giant cell arteritis, in particular in those cases with a predominance of extracranial large-vessel manifestations. Conclusions Giant cell arteritis is a more heterogeneous condition than previously thought. Awareness of all the potential clinical manifestations and judicious use of diagnostic tests may be an aid to avoid delayed detection and consequently ominous complications. |
| first_indexed | 2024-12-11T07:57:07Z |
| format | Article |
| id | doaj.art-68e0dfeadb1d4770bc4271d5842b7f2e |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-12-11T07:57:07Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-68e0dfeadb1d4770bc4271d5842b7f2e2022-12-22T01:15:12ZengBMCBMC Geriatrics1471-23182019-07-011911710.1186/s12877-019-1225-9Giant cell arteritis: is the clinical spectrum of the disease changing?Miguel Á. González-Gay0Miguel Ortego-Jurado1Liliana Ercole2Norberto Ortego-Centeno3Division of Rheumatology and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de ValdecillaEmergency Health Services Agency-061 (EPES-061)Medical Department, Roche PharmaAutoimmune Diseases Unit, Hospital Universitario San Cecilio, Instituto de Investigación Biosanitaria de Granada (IBS. GRANADA), Department of Internal Medicine, Professor of Medicine of the University of GranadaAbstract Background Giant cell arteritis is a vasculitis of large and middle-sized arteries that affects patients aged over 50 years. It can show a typical clinical picture consisting of cranial manifestations but sometimes nonspecific symptoms and large-vessel involvement prevail. Prompt diagnosis and treatment is essential to avoid irreversible damage. Discussion There has been an increasing knowledge on the occurrence of the disease without the typical cranial symptoms and its close relationship and overlap with polymyalgia rheumatica, and this may contribute to reduce the number of underdiagnosed patients. Although temporal artery biopsy is still the gold-standard and temporal artery ultrasonography is being widely used, newer imaging techniques (FDG-PET/TAC, MRI, CT) can be of valuable help to identify giant cell arteritis, in particular in those cases with a predominance of extracranial large-vessel manifestations. Conclusions Giant cell arteritis is a more heterogeneous condition than previously thought. Awareness of all the potential clinical manifestations and judicious use of diagnostic tests may be an aid to avoid delayed detection and consequently ominous complications.http://link.springer.com/article/10.1186/s12877-019-1225-9Giant-cell arteritisPolymyalgia rheumaticaFDG-PET/CT |
| spellingShingle | Miguel Á. González-Gay Miguel Ortego-Jurado Liliana Ercole Norberto Ortego-Centeno Giant cell arteritis: is the clinical spectrum of the disease changing? BMC Geriatrics Giant-cell arteritis Polymyalgia rheumatica FDG-PET/CT |
| title | Giant cell arteritis: is the clinical spectrum of the disease changing? |
| title_full | Giant cell arteritis: is the clinical spectrum of the disease changing? |
| title_fullStr | Giant cell arteritis: is the clinical spectrum of the disease changing? |
| title_full_unstemmed | Giant cell arteritis: is the clinical spectrum of the disease changing? |
| title_short | Giant cell arteritis: is the clinical spectrum of the disease changing? |
| title_sort | giant cell arteritis is the clinical spectrum of the disease changing |
| topic | Giant-cell arteritis Polymyalgia rheumatica FDG-PET/CT |
| url | http://link.springer.com/article/10.1186/s12877-019-1225-9 |
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