Prognostic and Predictive Effects of Positive Lymph Node Number or Ratio in NSCLC
Abstract In the eighth TNM staging system proposal for NSCLC recently, classification of N stage is based on anatomical position of positive lymph nodes. We aimed to expand the sample volume to identify the value of positive lymph node number or ratio in prognosis and predictive effect for postopera...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-00619-5 |
| _version_ | 1819036315618902016 |
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| author | Nan Ding ZhaoFei Pang Xiangwei Zhang Cuicui Huang Yufan Yang Qi Liu Jiajun Du |
| author_facet | Nan Ding ZhaoFei Pang Xiangwei Zhang Cuicui Huang Yufan Yang Qi Liu Jiajun Du |
| author_sort | Nan Ding |
| collection | DOAJ |
| description | Abstract In the eighth TNM staging system proposal for NSCLC recently, classification of N stage is based on anatomical position of positive lymph nodes. We aimed to expand the sample volume to identify the value of positive lymph node number or ratio in prognosis and predictive effect for postoperative radiation. Clinicopathological characters of 109026 NSCLC patients were collected from the SEER Database. Kaplan-Meier curves and cox regression methods were used for survival analysis. Compared with positive lymph node number equal to 0, 1–3 and >3 groups were independent prognostic factors (1–3: HR 2.856, p < 0.001; >3: HR 3.358, p < 0.001), so as the 0–50% and >50% positive lymph node ratio groups (0–50%: HR 2.124, p < 0.001; >50%: HR 3.358, p < 0.001). And in the groups of N2&positive lymph node number ≥4 and N2&positive lymph node ratio >50%, postoperative radiation related to positive prognosis of NSCLC patients. In conclusion, positive lymph node number or ratio was associated with survival as an independent indicator in NSCLC. They also had predictive effects for postoperative radiation, while N nodal stage not. |
| first_indexed | 2024-12-21T08:03:34Z |
| format | Article |
| id | doaj.art-68e4e2c7ff9549f19cf9ecdd5dd12468 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-21T08:03:34Z |
| publishDate | 2017-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-68e4e2c7ff9549f19cf9ecdd5dd124682022-12-21T19:10:51ZengNature PortfolioScientific Reports2045-23222017-04-01711910.1038/s41598-017-00619-5Prognostic and Predictive Effects of Positive Lymph Node Number or Ratio in NSCLCNan Ding0ZhaoFei Pang1Xiangwei Zhang2Cuicui Huang3Yufan Yang4Qi Liu5Jiajun Du6Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong UniversityInstitute of Oncology, Shandong Provincial Hospital Affiliated to Shandong UniversityDepartment of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong UniversityInstitute of Oncology, Shandong Provincial Hospital Affiliated to Shandong UniversityInstitute of Oncology, Shandong Provincial Hospital Affiliated to Shandong UniversityInstitute of Oncology, Shandong Provincial Hospital Affiliated to Shandong UniversityInstitute of Oncology, Shandong Provincial Hospital Affiliated to Shandong UniversityAbstract In the eighth TNM staging system proposal for NSCLC recently, classification of N stage is based on anatomical position of positive lymph nodes. We aimed to expand the sample volume to identify the value of positive lymph node number or ratio in prognosis and predictive effect for postoperative radiation. Clinicopathological characters of 109026 NSCLC patients were collected from the SEER Database. Kaplan-Meier curves and cox regression methods were used for survival analysis. Compared with positive lymph node number equal to 0, 1–3 and >3 groups were independent prognostic factors (1–3: HR 2.856, p < 0.001; >3: HR 3.358, p < 0.001), so as the 0–50% and >50% positive lymph node ratio groups (0–50%: HR 2.124, p < 0.001; >50%: HR 3.358, p < 0.001). And in the groups of N2&positive lymph node number ≥4 and N2&positive lymph node ratio >50%, postoperative radiation related to positive prognosis of NSCLC patients. In conclusion, positive lymph node number or ratio was associated with survival as an independent indicator in NSCLC. They also had predictive effects for postoperative radiation, while N nodal stage not.https://doi.org/10.1038/s41598-017-00619-5 |
| spellingShingle | Nan Ding ZhaoFei Pang Xiangwei Zhang Cuicui Huang Yufan Yang Qi Liu Jiajun Du Prognostic and Predictive Effects of Positive Lymph Node Number or Ratio in NSCLC Scientific Reports |
| title | Prognostic and Predictive Effects of Positive Lymph Node Number or Ratio in NSCLC |
| title_full | Prognostic and Predictive Effects of Positive Lymph Node Number or Ratio in NSCLC |
| title_fullStr | Prognostic and Predictive Effects of Positive Lymph Node Number or Ratio in NSCLC |
| title_full_unstemmed | Prognostic and Predictive Effects of Positive Lymph Node Number or Ratio in NSCLC |
| title_short | Prognostic and Predictive Effects of Positive Lymph Node Number or Ratio in NSCLC |
| title_sort | prognostic and predictive effects of positive lymph node number or ratio in nsclc |
| url | https://doi.org/10.1038/s41598-017-00619-5 |
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