Reactive oxygen species: a volatile driver of field cancerization and metastasis
Abstract Field cancerization and metastasis are the leading causes for cancer recurrence and mortality in cancer patients. The formation of primary, secondary tumors or metastasis is greatly influenced by multifaceted tumor-stroma interactions, in which stromal components of the tumor microenvironme...
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Format: | Article |
Language: | English |
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BMC
2019-03-01
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Series: | Molecular Cancer |
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Online Access: | http://link.springer.com/article/10.1186/s12943-019-0961-y |
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author | Zehuan Liao Damien Chua Nguan Soon Tan |
author_facet | Zehuan Liao Damien Chua Nguan Soon Tan |
author_sort | Zehuan Liao |
collection | DOAJ |
description | Abstract Field cancerization and metastasis are the leading causes for cancer recurrence and mortality in cancer patients. The formation of primary, secondary tumors or metastasis is greatly influenced by multifaceted tumor-stroma interactions, in which stromal components of the tumor microenvironment (TME) can affect the behavior of the cancer cells. Many studies have identified cytokines and growth factors as cell signaling molecules that aid cell to cell communication. However, the functional contribution of reactive oxygen species (ROS), a family of volatile chemicals, as communication molecules are less understood. Cancer cells and various tumor-associated stromal cells produce and secrete a copious amount of ROS into the TME. Intracellular ROS modulate cell signaling cascades that aid in the acquisition of several hallmarks of cancers. Extracellular ROS help to propagate, amplify, and effectively create a mutagenic and oncogenic field which facilitate the formation of multifoci tumors and act as a springboard for metastatic tumor cells. In this review, we summarize our current knowledge of ROS as atypical paracrine signaling molecules for field cancerization and metastasis. Field cancerization and metastasis are often discussed separately; we offer a model that placed these events with ROS as the focal instigating agent in a broader “seed-soil” hypothesis. |
first_indexed | 2024-12-14T23:04:21Z |
format | Article |
id | doaj.art-68e513671458490695d5b2115c600f01 |
institution | Directory Open Access Journal |
issn | 1476-4598 |
language | English |
last_indexed | 2024-12-14T23:04:21Z |
publishDate | 2019-03-01 |
publisher | BMC |
record_format | Article |
series | Molecular Cancer |
spelling | doaj.art-68e513671458490695d5b2115c600f012022-12-21T22:44:22ZengBMCMolecular Cancer1476-45982019-03-0118111010.1186/s12943-019-0961-yReactive oxygen species: a volatile driver of field cancerization and metastasisZehuan Liao0Damien Chua1Nguan Soon Tan2School of Biological Sciences, Nanyang Technological University SingaporeSchool of Biological Sciences, Nanyang Technological University SingaporeSchool of Biological Sciences, Nanyang Technological University SingaporeAbstract Field cancerization and metastasis are the leading causes for cancer recurrence and mortality in cancer patients. The formation of primary, secondary tumors or metastasis is greatly influenced by multifaceted tumor-stroma interactions, in which stromal components of the tumor microenvironment (TME) can affect the behavior of the cancer cells. Many studies have identified cytokines and growth factors as cell signaling molecules that aid cell to cell communication. However, the functional contribution of reactive oxygen species (ROS), a family of volatile chemicals, as communication molecules are less understood. Cancer cells and various tumor-associated stromal cells produce and secrete a copious amount of ROS into the TME. Intracellular ROS modulate cell signaling cascades that aid in the acquisition of several hallmarks of cancers. Extracellular ROS help to propagate, amplify, and effectively create a mutagenic and oncogenic field which facilitate the formation of multifoci tumors and act as a springboard for metastatic tumor cells. In this review, we summarize our current knowledge of ROS as atypical paracrine signaling molecules for field cancerization and metastasis. Field cancerization and metastasis are often discussed separately; we offer a model that placed these events with ROS as the focal instigating agent in a broader “seed-soil” hypothesis.http://link.springer.com/article/10.1186/s12943-019-0961-yReactive oxygen speciesField cancerizationMetastasisTumor microenvironmentCancer-associated fibroblastsTumor-associated macrophages |
spellingShingle | Zehuan Liao Damien Chua Nguan Soon Tan Reactive oxygen species: a volatile driver of field cancerization and metastasis Molecular Cancer Reactive oxygen species Field cancerization Metastasis Tumor microenvironment Cancer-associated fibroblasts Tumor-associated macrophages |
title | Reactive oxygen species: a volatile driver of field cancerization and metastasis |
title_full | Reactive oxygen species: a volatile driver of field cancerization and metastasis |
title_fullStr | Reactive oxygen species: a volatile driver of field cancerization and metastasis |
title_full_unstemmed | Reactive oxygen species: a volatile driver of field cancerization and metastasis |
title_short | Reactive oxygen species: a volatile driver of field cancerization and metastasis |
title_sort | reactive oxygen species a volatile driver of field cancerization and metastasis |
topic | Reactive oxygen species Field cancerization Metastasis Tumor microenvironment Cancer-associated fibroblasts Tumor-associated macrophages |
url | http://link.springer.com/article/10.1186/s12943-019-0961-y |
work_keys_str_mv | AT zehuanliao reactiveoxygenspeciesavolatiledriveroffieldcancerizationandmetastasis AT damienchua reactiveoxygenspeciesavolatiledriveroffieldcancerizationandmetastasis AT nguansoontan reactiveoxygenspeciesavolatiledriveroffieldcancerizationandmetastasis |