Affective temperaments show stronger association with infertility treatment success compared to somatic factors, highlighting the role of personality focused interventions
Abstract Infertility has a multifactorial background, where, besides somatic factors, psychological contributors also play a role in development and outcome. While affective temperaments have been associated with development, course, and outcome as well as treatment success in various somatic condit...
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Nature Portfolio
2023-12-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-47969-x |
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author | Georgina Szabo Judit Szigeti F. Miklos Sipos Szabolcs Varbiro Xenia Gonda |
author_facet | Georgina Szabo Judit Szigeti F. Miklos Sipos Szabolcs Varbiro Xenia Gonda |
author_sort | Georgina Szabo |
collection | DOAJ |
description | Abstract Infertility has a multifactorial background, where, besides somatic factors, psychological contributors also play a role in development and outcome. While affective temperaments have been associated with development, course, and outcome as well as treatment success in various somatic conditions, their association with infertility and its treatment has not been investigated so far. The purpose of our retrospective cohort study was to evaluate the influence of affective temperaments on fertility treatment outcomes. Among 578 women who underwent infertility treatment in an Assisted Reproduction Centre in Budapest, Hungary, treatment success, detailed medical history, and demographic parameters were recorded, and the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A) was administered. Possible predictors of assisted reproduction outcome were analyzed using multivariate logistic regression models, followed by a receiver operating curve (ROC) analysis in order to define ideal affective temperament cut-off values for clinical applicability. Aside from age, BMI, and previous miscarriage, cyclothymic scores > 4 (OR = 0.51 CI 0.35–0.74, p < 0.001), depressive scores > 9 (OR = 0.59 CI 0.4–0.87, p = 0.009) and anxious scores > 9 (OR = 0.45 CI 0.31–0.66, p < 0.001) significantly decreased the odds of clinical pregnancy by 49%, 41% and 55%, respectively. Irritable and hyperthymic temperaments, as well as other somatic and socio-economic factors had no effect on infertility treatment outcomes. The results suggest that affective temperaments may be related to the outcome of infertility treatments. Thus, screening for affective temperaments may help identify high-risk patient groups and offer patient-tailored treatment, which may increase the chances of a successful pregnancy and live birth for women undergoing IVF treatment. |
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language | English |
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publishDate | 2023-12-01 |
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spelling | doaj.art-68e828a3e2384e839e0864ec2450383a2023-12-17T12:12:50ZengNature PortfolioScientific Reports2045-23222023-12-0113111110.1038/s41598-023-47969-xAffective temperaments show stronger association with infertility treatment success compared to somatic factors, highlighting the role of personality focused interventionsGeorgina Szabo0Judit Szigeti F.1Miklos Sipos2Szabolcs Varbiro3Xenia Gonda4Doctoral School of Mental Health Sciences, Semmelweis UniversityInstitute of Behavioral Sciences, Semmelweis UniversityDepartment of Obstetrics and Gynecology, Semmelweis UniversityDepartment of Obstetrics and Gynecology, Semmelweis UniversityDepartment of Psychiatry and Psychotherapy, Semmelweis UniversityAbstract Infertility has a multifactorial background, where, besides somatic factors, psychological contributors also play a role in development and outcome. While affective temperaments have been associated with development, course, and outcome as well as treatment success in various somatic conditions, their association with infertility and its treatment has not been investigated so far. The purpose of our retrospective cohort study was to evaluate the influence of affective temperaments on fertility treatment outcomes. Among 578 women who underwent infertility treatment in an Assisted Reproduction Centre in Budapest, Hungary, treatment success, detailed medical history, and demographic parameters were recorded, and the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A) was administered. Possible predictors of assisted reproduction outcome were analyzed using multivariate logistic regression models, followed by a receiver operating curve (ROC) analysis in order to define ideal affective temperament cut-off values for clinical applicability. Aside from age, BMI, and previous miscarriage, cyclothymic scores > 4 (OR = 0.51 CI 0.35–0.74, p < 0.001), depressive scores > 9 (OR = 0.59 CI 0.4–0.87, p = 0.009) and anxious scores > 9 (OR = 0.45 CI 0.31–0.66, p < 0.001) significantly decreased the odds of clinical pregnancy by 49%, 41% and 55%, respectively. Irritable and hyperthymic temperaments, as well as other somatic and socio-economic factors had no effect on infertility treatment outcomes. The results suggest that affective temperaments may be related to the outcome of infertility treatments. Thus, screening for affective temperaments may help identify high-risk patient groups and offer patient-tailored treatment, which may increase the chances of a successful pregnancy and live birth for women undergoing IVF treatment.https://doi.org/10.1038/s41598-023-47969-x |
spellingShingle | Georgina Szabo Judit Szigeti F. Miklos Sipos Szabolcs Varbiro Xenia Gonda Affective temperaments show stronger association with infertility treatment success compared to somatic factors, highlighting the role of personality focused interventions Scientific Reports |
title | Affective temperaments show stronger association with infertility treatment success compared to somatic factors, highlighting the role of personality focused interventions |
title_full | Affective temperaments show stronger association with infertility treatment success compared to somatic factors, highlighting the role of personality focused interventions |
title_fullStr | Affective temperaments show stronger association with infertility treatment success compared to somatic factors, highlighting the role of personality focused interventions |
title_full_unstemmed | Affective temperaments show stronger association with infertility treatment success compared to somatic factors, highlighting the role of personality focused interventions |
title_short | Affective temperaments show stronger association with infertility treatment success compared to somatic factors, highlighting the role of personality focused interventions |
title_sort | affective temperaments show stronger association with infertility treatment success compared to somatic factors highlighting the role of personality focused interventions |
url | https://doi.org/10.1038/s41598-023-47969-x |
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