Magnetic Resonance Imaging of Hemophilic Joints: Correlations with the Bleeding Phenotype and Physical Examination
Introduction: Blood-induced joint damage as a hallmark of haemophilia continues to occur despite the widespread prophylaxis. Pre-cise assessment and follow-up of joint status are crucial for tailoring their treatment. Aim: To study the correlation between the bleeding phenotype, the fun...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2020-12-01
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| Series: | Folia Medica |
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| Online Access: | https://foliamedica.bg/article/50550/download/pdf/ |
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| author | Neofit Spasov Diana Dimitrova-Popova Nikoleta Traikova-Djambazova Mariya Spasova Miroslava Bosheva |
| author_facet | Neofit Spasov Diana Dimitrova-Popova Nikoleta Traikova-Djambazova Mariya Spasova Miroslava Bosheva |
| author_sort | Neofit Spasov |
| collection | DOAJ |
| description | Introduction: Blood-induced joint damage as a hallmark of haemophilia continues to occur despite the widespread prophylaxis. Pre-cise assessment and follow-up of joint status are crucial for tailoring their treatment. Aim: To study the correlation between the bleeding phenotype, the functional joint status, and the magnetic resonance imaging score in pediatric patients with haemophilia.Materials and methods: Eighty-six joints (ankles, knees, and elbows) in patients aged 10.7±0.5 (range 4 - 20) years with severe/moderate haemophilia A, severe haemophilia B and haemophilia A with inhibitors were included in the study. The joints were assessed by Haemophilia Joint Health Score 2.1 (HJHS2.1) one month after the last hemarthrosis in a non-bleeding state. The magnetic reso-nance imaging was performed on 40 (46.5%) of the examined hemophilic joints (16 ankles, 11 knees and 13 elbows). Results: Joint bleeds were present in 37 (38.9%) of the joints with ankles being the most commonly affected. Sixty joints (69.8%) had normal HJHS2.1 score. Only the loss of flexion score differed significantly between the joints and the ankles had highest score. The cumulative number of hemarthrosis in the joint correlated moderately with hemosiderin deposition and strongly with the formation of subchondral cysts on magnetic resonance imaging. The magnetic resonance imaging scores for soft tissue and osteochondral domains correlated moderately with the cumulative number of hemarthrosis in the joint and only with the presence of pain and crepitus of mo-tion from the physical examination.Conclusions: Magnetic resonance imaging is more sensitive than the bleeding phenotype and physical examination in detecting early signs of haemophilic arthropathy. |
| first_indexed | 2024-12-24T00:47:20Z |
| format | Article |
| id | doaj.art-68e87f092c1046fea5fdf1a1de7cecfb |
| institution | Directory Open Access Journal |
| issn | 1314-2143 |
| language | English |
| last_indexed | 2024-12-24T00:47:20Z |
| publishDate | 2020-12-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Folia Medica |
| spelling | doaj.art-68e87f092c1046fea5fdf1a1de7cecfb2022-12-21T17:23:46ZengPensoft PublishersFolia Medica1314-21432020-12-0162476276810.3897/folmed.62.e5055050550Magnetic Resonance Imaging of Hemophilic Joints: Correlations with the Bleeding Phenotype and Physical ExaminationNeofit Spasov0Diana Dimitrova-Popova1Nikoleta Traikova-Djambazova2Mariya Spasova3Miroslava Bosheva4Medical University of PlovdivMedical University of PlovdivMedical University of PlovdivMedical University of PlovdivMedical University of PlovdivIntroduction: Blood-induced joint damage as a hallmark of haemophilia continues to occur despite the widespread prophylaxis. Pre-cise assessment and follow-up of joint status are crucial for tailoring their treatment. Aim: To study the correlation between the bleeding phenotype, the functional joint status, and the magnetic resonance imaging score in pediatric patients with haemophilia.Materials and methods: Eighty-six joints (ankles, knees, and elbows) in patients aged 10.7±0.5 (range 4 - 20) years with severe/moderate haemophilia A, severe haemophilia B and haemophilia A with inhibitors were included in the study. The joints were assessed by Haemophilia Joint Health Score 2.1 (HJHS2.1) one month after the last hemarthrosis in a non-bleeding state. The magnetic reso-nance imaging was performed on 40 (46.5%) of the examined hemophilic joints (16 ankles, 11 knees and 13 elbows). Results: Joint bleeds were present in 37 (38.9%) of the joints with ankles being the most commonly affected. Sixty joints (69.8%) had normal HJHS2.1 score. Only the loss of flexion score differed significantly between the joints and the ankles had highest score. The cumulative number of hemarthrosis in the joint correlated moderately with hemosiderin deposition and strongly with the formation of subchondral cysts on magnetic resonance imaging. The magnetic resonance imaging scores for soft tissue and osteochondral domains correlated moderately with the cumulative number of hemarthrosis in the joint and only with the presence of pain and crepitus of mo-tion from the physical examination.Conclusions: Magnetic resonance imaging is more sensitive than the bleeding phenotype and physical examination in detecting early signs of haemophilic arthropathy.https://foliamedica.bg/article/50550/download/pdf/hemarthrosishaemophilic jointshaemophilia join |
| spellingShingle | Neofit Spasov Diana Dimitrova-Popova Nikoleta Traikova-Djambazova Mariya Spasova Miroslava Bosheva Magnetic Resonance Imaging of Hemophilic Joints: Correlations with the Bleeding Phenotype and Physical Examination Folia Medica hemarthrosis haemophilic joints haemophilia join |
| title | Magnetic Resonance Imaging of Hemophilic Joints: Correlations with the Bleeding Phenotype and Physical Examination |
| title_full | Magnetic Resonance Imaging of Hemophilic Joints: Correlations with the Bleeding Phenotype and Physical Examination |
| title_fullStr | Magnetic Resonance Imaging of Hemophilic Joints: Correlations with the Bleeding Phenotype and Physical Examination |
| title_full_unstemmed | Magnetic Resonance Imaging of Hemophilic Joints: Correlations with the Bleeding Phenotype and Physical Examination |
| title_short | Magnetic Resonance Imaging of Hemophilic Joints: Correlations with the Bleeding Phenotype and Physical Examination |
| title_sort | magnetic resonance imaging of hemophilic joints correlations with the bleeding phenotype and physical examination |
| topic | hemarthrosis haemophilic joints haemophilia join |
| url | https://foliamedica.bg/article/50550/download/pdf/ |
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