The Growing Relevance of Immunoregulation in Pediatric Brain Tumors
Pediatric brain tumors are genetically heterogeneous solid neoplasms. With a prevailing poor prognosis and widespread resistance to conventional multimodal therapy, these aggressive tumors are the leading cause of childhood cancer-related deaths worldwide. Advancement in molecular research revealed...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/22/5601 |
| _version_ | 1797511007565774848 |
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| author | Viktoria Melcher Kornelius Kerl |
| author_facet | Viktoria Melcher Kornelius Kerl |
| author_sort | Viktoria Melcher |
| collection | DOAJ |
| description | Pediatric brain tumors are genetically heterogeneous solid neoplasms. With a prevailing poor prognosis and widespread resistance to conventional multimodal therapy, these aggressive tumors are the leading cause of childhood cancer-related deaths worldwide. Advancement in molecular research revealed their unique genetic and epigenetic characteristics and paved the way for more defined prognostication and targeted therapeutic approaches. Furthermore, uncovering the intratumoral metrics on a single-cell level placed non-malignant cell populations such as innate immune cells into the context of tumor manifestation and progression. Targeting immune cells in pediatric brain tumors entails unique challenges but promising opportunities to improve outcome. Herein, we outline the current understanding of the role of the immune regulation in pediatric brain tumors. |
| first_indexed | 2024-03-10T05:39:20Z |
| format | Article |
| id | doaj.art-68e940d503584f9384e8c10427a4eeca |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T05:39:20Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-68e940d503584f9384e8c10427a4eeca2023-11-22T22:40:30ZengMDPI AGCancers2072-66942021-11-011322560110.3390/cancers13225601The Growing Relevance of Immunoregulation in Pediatric Brain TumorsViktoria Melcher0Kornelius Kerl1Department of Pediatric Hematology and Oncology, University Children’s Hospital Münster, 48149 Münster, GermanyDepartment of Pediatric Hematology and Oncology, University Children’s Hospital Münster, 48149 Münster, GermanyPediatric brain tumors are genetically heterogeneous solid neoplasms. With a prevailing poor prognosis and widespread resistance to conventional multimodal therapy, these aggressive tumors are the leading cause of childhood cancer-related deaths worldwide. Advancement in molecular research revealed their unique genetic and epigenetic characteristics and paved the way for more defined prognostication and targeted therapeutic approaches. Furthermore, uncovering the intratumoral metrics on a single-cell level placed non-malignant cell populations such as innate immune cells into the context of tumor manifestation and progression. Targeting immune cells in pediatric brain tumors entails unique challenges but promising opportunities to improve outcome. Herein, we outline the current understanding of the role of the immune regulation in pediatric brain tumors.https://www.mdpi.com/2072-6694/13/22/5601pediatric brain tumorsembryonal brain tumorsatypical teratoid/rhabdoid tumorependymomahigh-grade gliomalow-grade glioma |
| spellingShingle | Viktoria Melcher Kornelius Kerl The Growing Relevance of Immunoregulation in Pediatric Brain Tumors Cancers pediatric brain tumors embryonal brain tumors atypical teratoid/rhabdoid tumor ependymoma high-grade glioma low-grade glioma |
| title | The Growing Relevance of Immunoregulation in Pediatric Brain Tumors |
| title_full | The Growing Relevance of Immunoregulation in Pediatric Brain Tumors |
| title_fullStr | The Growing Relevance of Immunoregulation in Pediatric Brain Tumors |
| title_full_unstemmed | The Growing Relevance of Immunoregulation in Pediatric Brain Tumors |
| title_short | The Growing Relevance of Immunoregulation in Pediatric Brain Tumors |
| title_sort | growing relevance of immunoregulation in pediatric brain tumors |
| topic | pediatric brain tumors embryonal brain tumors atypical teratoid/rhabdoid tumor ependymoma high-grade glioma low-grade glioma |
| url | https://www.mdpi.com/2072-6694/13/22/5601 |
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