Diazinon and Cadmium Neurotoxicity in Rats after an Experimental Administration
The aim of this study was to describe the changes in cholinesterase activity in separate doses and after co-administration of cadmium and diazinon intraperitoneally and to assess toxicity and interactions of diazinon and cadmium on the nervous system in male rats. 40 male rats were randomly divided...
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| Format: | Članak |
| Jezik: | English |
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Agroprint Timisoara
2023-09-01
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| Serija: | Scientific Papers Animal Science and Biotechnologies |
| Teme: | |
| Online pristup: | https://spasb.ro/index.php/public_html/article/view/682 |
| _version_ | 1827288318769889280 |
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| author | Róbert Toman Svätoslav Hluchý Jozef Golian Michal Cabaj Mária Adamkovičová |
| author_facet | Róbert Toman Svätoslav Hluchý Jozef Golian Michal Cabaj Mária Adamkovičová |
| author_sort | Róbert Toman |
| collection | DOAJ |
| description | The aim of this study was to describe the changes in cholinesterase activity in separate doses and after co-administration of cadmium and diazinon intraperitoneally and to assess toxicity and interactions of diazinon and cadmium on the nervous system in male rats. 40 male rats were randomly divided into three experimental and one control group (10 rats in each group). Blood analyzes were performed 36 hours after an intraperitoneal administration of observed compounds. The statistical evaluation of the results showed significantly (P < 0.01) reduced activity of cholinesterase in all experimental groups. The enzyme activity decreased from the control value 3.69 μkat/L to 1.81 μkat/L (diazinon group), 1.83 μkat/L (cadmium group) and 1.35 μkat/L (cadmium+diazinon group). These results indicate that both cadmium and diazinon are potent to manifest the neurotoxic effects. Moreover, a synergistic effect of the co-administered cadmium and diazinon in the nervous system has been observed. |
| first_indexed | 2024-04-24T11:28:50Z |
| format | Article |
| id | doaj.art-68eb6c4540bc4a04a79b1feb8e2e0290 |
| institution | Directory Open Access Journal |
| issn | 1841-9364 2344-4576 |
| language | English |
| last_indexed | 2024-04-24T11:28:50Z |
| publishDate | 2023-09-01 |
| publisher | Agroprint Timisoara |
| record_format | Article |
| series | Scientific Papers Animal Science and Biotechnologies |
| spelling | doaj.art-68eb6c4540bc4a04a79b1feb8e2e02902024-04-10T11:07:19ZengAgroprint TimisoaraScientific Papers Animal Science and Biotechnologies1841-93642344-45762023-09-01452137137682Diazinon and Cadmium Neurotoxicity in Rats after an Experimental AdministrationRóbert Toman0Svätoslav Hluchý1Jozef Golian2Michal Cabaj3Mária Adamkovičová4Slovak University of Agriculture, Faculty of Agrobiology and Food Resources, Tr. A. Hlinku 2, 94976 - Nitra, SlovakiaSlovak University of Agriculture, Faculty of Agrobiology and Food Resources, Tr. A. Hlinku 2, 94976 - Nitra, SlovakiaSlovak University of Agriculture, Faculty of Biotechnology and Food Sciences, Tr. A. Hlinku 2, 94976 - Nitra, SlovakiaSlovak University of Agriculture, Faculty of Agrobiology and Food Resources, Tr. A. Hlinku 2, 94976 - Nitra, SlovakiaSlovak University of Agriculture, Faculty of Agrobiology and Food Resources, Tr. A. Hlinku 2, 94976 - Nitra, SlovakiaThe aim of this study was to describe the changes in cholinesterase activity in separate doses and after co-administration of cadmium and diazinon intraperitoneally and to assess toxicity and interactions of diazinon and cadmium on the nervous system in male rats. 40 male rats were randomly divided into three experimental and one control group (10 rats in each group). Blood analyzes were performed 36 hours after an intraperitoneal administration of observed compounds. The statistical evaluation of the results showed significantly (P < 0.01) reduced activity of cholinesterase in all experimental groups. The enzyme activity decreased from the control value 3.69 μkat/L to 1.81 μkat/L (diazinon group), 1.83 μkat/L (cadmium group) and 1.35 μkat/L (cadmium+diazinon group). These results indicate that both cadmium and diazinon are potent to manifest the neurotoxic effects. Moreover, a synergistic effect of the co-administered cadmium and diazinon in the nervous system has been observed.https://spasb.ro/index.php/public_html/article/view/682cadmiumcholinesterasediazinonneurotoxicityrat |
| spellingShingle | Róbert Toman Svätoslav Hluchý Jozef Golian Michal Cabaj Mária Adamkovičová Diazinon and Cadmium Neurotoxicity in Rats after an Experimental Administration Scientific Papers Animal Science and Biotechnologies cadmium cholinesterase diazinon neurotoxicity rat |
| title | Diazinon and Cadmium Neurotoxicity in Rats after an Experimental Administration |
| title_full | Diazinon and Cadmium Neurotoxicity in Rats after an Experimental Administration |
| title_fullStr | Diazinon and Cadmium Neurotoxicity in Rats after an Experimental Administration |
| title_full_unstemmed | Diazinon and Cadmium Neurotoxicity in Rats after an Experimental Administration |
| title_short | Diazinon and Cadmium Neurotoxicity in Rats after an Experimental Administration |
| title_sort | diazinon and cadmium neurotoxicity in rats after an experimental administration |
| topic | cadmium cholinesterase diazinon neurotoxicity rat |
| url | https://spasb.ro/index.php/public_html/article/view/682 |
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