Ganglioside GM3 activates ERKs in human lymphocytic cells

Ganglioside GM3 activates ERKs in human lymphocytic cells

In this study we analyzed the signaling pathway triggered by GM3 in lymphoblastoid T-cells. In these cells, GM3 induced cPLA2 activation, arachidonic acid release, and PKC-δ translocation. In order to clarify the upstream molecular signals triggered by GM3, we analyzed the activation of extracellula...

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Bibliographic Details
Main Authors: Tina Garofalo, Maurizio Sorice, Roberta Misasi, Benedetta Cinque, Vincenzo Mattei, Giuseppe M. Pontieri, Maria Grazia Cifone, Antonio Pavan
Format: Article
Language:English
Published: Elsevier 2002-06-01
Series:Journal of Lipid Research
Subjects:
extracellular signal-regulated kinase
CD4
lipid domains
glycosphingolipids
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520304727

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