Analysis of the Influence of Thyroid Nodule Characteristics on the Results of Shear Wave Elastography
ObjectiveTo analyze the ultrasonic characteristics of false-negative and false-positive results of shear wave elastography (SWE) in the diagnosis of thyroid nodules to clarify the influence of nodular characteristics on SWE and to guide the clinical application of SWE.MethodsA total of 435 thyroid n...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.858565/full |
| _version_ | 1818552750853586944 |
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| author | Ji-ping Xue Xiao-yan Kang Jun-wang Miao Yan-xia Zhang Hui-zhan Li Fu-cheng Yao Chun-song Kang |
| author_facet | Ji-ping Xue Xiao-yan Kang Jun-wang Miao Yan-xia Zhang Hui-zhan Li Fu-cheng Yao Chun-song Kang |
| author_sort | Ji-ping Xue |
| collection | DOAJ |
| description | ObjectiveTo analyze the ultrasonic characteristics of false-negative and false-positive results of shear wave elastography (SWE) in the diagnosis of thyroid nodules to clarify the influence of nodular characteristics on SWE and to guide the clinical application of SWE.MethodsA total of 435 thyroid nodules from 343 patients with the diagnosis confirmed by surgical pathology were analyzed. Preoperative ultrasonography and SWE were conducted. The conventional ultrasound characteristics of thyroid nodules and the maximum Young’s modulus were recorded. The false negativity and false positivity of SWE for the diagnosis of thyroid nodules were calculated. The ultrasonic characteristics of thyroid nodules with SWE false results were analyzed, and logistic regression analysis was adopted to determine the ultrasonic characteristics associated with SWE false results of thyroid nodules.ResultsAmong 323 malignant nodules, the SWE false negativity was 27.2% (88/323). The false positivity of SWE in 112 benign nodules was 19.6% (22/112). Regression analysis showed that an increase in the nodule volume increased the risk of SWE false-positive results (odds ratio [OR] 3.286; 95% confidence interval [CI]: 1.572–6.871; P = 0.002) and decreased the risk of false-negative results (OR 0.238; 95% CI: 0.115–0.493; P < 0.001). Nodules with coarse calcification had an increased risk of SWE false-positive results compared with those without calcification (OR 5.303; 95% CI: 1.098–25.619; P = 0.038). However, nodules with scattered hyperechoic foci had a reduced risk of SWE false-negative results (OR 0.515; 95% CI: 0.280–0.951; P = 0.034).ConclusionNodular size and calcification were correlated with SWE false results, and the clinical application of SWE should be combined with conventional ultrasound features. Fine needle aspiration or a puncture biopsy should be conducted if necessary. |
| first_indexed | 2024-12-12T09:17:15Z |
| format | Article |
| id | doaj.art-68f2b199ea624f43a9a00a16cf92dc55 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-12T09:17:15Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-68f2b199ea624f43a9a00a16cf92dc552022-12-22T00:29:21ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-06-011310.3389/fendo.2022.858565858565Analysis of the Influence of Thyroid Nodule Characteristics on the Results of Shear Wave ElastographyJi-ping XueXiao-yan KangJun-wang MiaoYan-xia ZhangHui-zhan LiFu-cheng YaoChun-song KangObjectiveTo analyze the ultrasonic characteristics of false-negative and false-positive results of shear wave elastography (SWE) in the diagnosis of thyroid nodules to clarify the influence of nodular characteristics on SWE and to guide the clinical application of SWE.MethodsA total of 435 thyroid nodules from 343 patients with the diagnosis confirmed by surgical pathology were analyzed. Preoperative ultrasonography and SWE were conducted. The conventional ultrasound characteristics of thyroid nodules and the maximum Young’s modulus were recorded. The false negativity and false positivity of SWE for the diagnosis of thyroid nodules were calculated. The ultrasonic characteristics of thyroid nodules with SWE false results were analyzed, and logistic regression analysis was adopted to determine the ultrasonic characteristics associated with SWE false results of thyroid nodules.ResultsAmong 323 malignant nodules, the SWE false negativity was 27.2% (88/323). The false positivity of SWE in 112 benign nodules was 19.6% (22/112). Regression analysis showed that an increase in the nodule volume increased the risk of SWE false-positive results (odds ratio [OR] 3.286; 95% confidence interval [CI]: 1.572–6.871; P = 0.002) and decreased the risk of false-negative results (OR 0.238; 95% CI: 0.115–0.493; P < 0.001). Nodules with coarse calcification had an increased risk of SWE false-positive results compared with those without calcification (OR 5.303; 95% CI: 1.098–25.619; P = 0.038). However, nodules with scattered hyperechoic foci had a reduced risk of SWE false-negative results (OR 0.515; 95% CI: 0.280–0.951; P = 0.034).ConclusionNodular size and calcification were correlated with SWE false results, and the clinical application of SWE should be combined with conventional ultrasound features. Fine needle aspiration or a puncture biopsy should be conducted if necessary.https://www.frontiersin.org/articles/10.3389/fendo.2022.858565/fullthyroidnodule characteristicsshear wave elastographyinfluenceultrasonography |
| spellingShingle | Ji-ping Xue Xiao-yan Kang Jun-wang Miao Yan-xia Zhang Hui-zhan Li Fu-cheng Yao Chun-song Kang Analysis of the Influence of Thyroid Nodule Characteristics on the Results of Shear Wave Elastography Frontiers in Endocrinology thyroid nodule characteristics shear wave elastography influence ultrasonography |
| title | Analysis of the Influence of Thyroid Nodule Characteristics on the Results of Shear Wave Elastography |
| title_full | Analysis of the Influence of Thyroid Nodule Characteristics on the Results of Shear Wave Elastography |
| title_fullStr | Analysis of the Influence of Thyroid Nodule Characteristics on the Results of Shear Wave Elastography |
| title_full_unstemmed | Analysis of the Influence of Thyroid Nodule Characteristics on the Results of Shear Wave Elastography |
| title_short | Analysis of the Influence of Thyroid Nodule Characteristics on the Results of Shear Wave Elastography |
| title_sort | analysis of the influence of thyroid nodule characteristics on the results of shear wave elastography |
| topic | thyroid nodule characteristics shear wave elastography influence ultrasonography |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.858565/full |
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