Single nucleotide polymorphisms and sporadic colorectal cancer susceptibility: a field synopsis and meta-analysis
Abstract Background Although mounting non-hereditary colorectal cancer (NHCRC) associated single nucleotide polymorphisms (SNPs) have been observed, no field synopsis and meta-analysis has been conducted through systematically assessing cumulative evidence, during the past 5 years. Methods We retrie...
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | Cancer Cell International |
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| Online Access: | http://link.springer.com/article/10.1186/s12935-018-0656-2 |
| _version_ | 1818851358506221568 |
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| author | Jing Wen Qian Xu Yuan Yuan |
| author_facet | Jing Wen Qian Xu Yuan Yuan |
| author_sort | Jing Wen |
| collection | DOAJ |
| description | Abstract Background Although mounting non-hereditary colorectal cancer (NHCRC) associated single nucleotide polymorphisms (SNPs) have been observed, no field synopsis and meta-analysis has been conducted through systematically assessing cumulative evidence, during the past 5 years. Methods We retrieved the database via the PubMed, Web of Science and Embase gateways to identify publications concerning the associations between SNPs and risk of NHCRC, up to May 1st, 2017. To assess the finding credibility, cumulative evidence was graded based on the Venice criteria. Meta-analysis was also performed for three subgroups including ethnicity (Asian vs Caucasian), primary cancer site (colon vs rectum) and TNM stage (I II vs III IV). Then, we arranged those high quality SNPs into different regions according to their locations on genes to evaluate their functional roles on CRC development. Results 5114 publications were collected and 1001 of them met our inclusion criteria, which totally included 1788 SNPs in 793 genes or distinct chromosomal loci. Totally, we performed 359 primary and subgroup meta-analyses for 160 SNPs in 96 distinct genes. By utilizing the Venice criteria, we identified 15 high quality SNPs with 25 high credibility significant associations. Furthermore, we artificially divided the high quality SNPs into different groups, based on their SNP loci (exon region, intron region, promoter region, downstream region, non-coding region and intergenic region). Conclusion We have identified 15 high quality SNPs which may act as promising genetic biomarkers for clinical NHCRC susceptibility screening and explored their functional roles on the NHCRC development based on their locations on genes. |
| first_indexed | 2024-12-19T07:03:45Z |
| format | Article |
| id | doaj.art-68f339a69d3443b4855e515703128e3b |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-19T07:03:45Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-68f339a69d3443b4855e515703128e3b2022-12-21T20:31:21ZengBMCCancer Cell International1475-28672018-10-0118111410.1186/s12935-018-0656-2Single nucleotide polymorphisms and sporadic colorectal cancer susceptibility: a field synopsis and meta-analysisJing Wen0Qian Xu1Yuan Yuan2Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical UniversityTumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical UniversityTumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical UniversityAbstract Background Although mounting non-hereditary colorectal cancer (NHCRC) associated single nucleotide polymorphisms (SNPs) have been observed, no field synopsis and meta-analysis has been conducted through systematically assessing cumulative evidence, during the past 5 years. Methods We retrieved the database via the PubMed, Web of Science and Embase gateways to identify publications concerning the associations between SNPs and risk of NHCRC, up to May 1st, 2017. To assess the finding credibility, cumulative evidence was graded based on the Venice criteria. Meta-analysis was also performed for three subgroups including ethnicity (Asian vs Caucasian), primary cancer site (colon vs rectum) and TNM stage (I II vs III IV). Then, we arranged those high quality SNPs into different regions according to their locations on genes to evaluate their functional roles on CRC development. Results 5114 publications were collected and 1001 of them met our inclusion criteria, which totally included 1788 SNPs in 793 genes or distinct chromosomal loci. Totally, we performed 359 primary and subgroup meta-analyses for 160 SNPs in 96 distinct genes. By utilizing the Venice criteria, we identified 15 high quality SNPs with 25 high credibility significant associations. Furthermore, we artificially divided the high quality SNPs into different groups, based on their SNP loci (exon region, intron region, promoter region, downstream region, non-coding region and intergenic region). Conclusion We have identified 15 high quality SNPs which may act as promising genetic biomarkers for clinical NHCRC susceptibility screening and explored their functional roles on the NHCRC development based on their locations on genes.http://link.springer.com/article/10.1186/s12935-018-0656-2Non-hereditary colorectal cancerSingle nucleotide polymorphismsField synopsisMeta-analysis |
| spellingShingle | Jing Wen Qian Xu Yuan Yuan Single nucleotide polymorphisms and sporadic colorectal cancer susceptibility: a field synopsis and meta-analysis Cancer Cell International Non-hereditary colorectal cancer Single nucleotide polymorphisms Field synopsis Meta-analysis |
| title | Single nucleotide polymorphisms and sporadic colorectal cancer susceptibility: a field synopsis and meta-analysis |
| title_full | Single nucleotide polymorphisms and sporadic colorectal cancer susceptibility: a field synopsis and meta-analysis |
| title_fullStr | Single nucleotide polymorphisms and sporadic colorectal cancer susceptibility: a field synopsis and meta-analysis |
| title_full_unstemmed | Single nucleotide polymorphisms and sporadic colorectal cancer susceptibility: a field synopsis and meta-analysis |
| title_short | Single nucleotide polymorphisms and sporadic colorectal cancer susceptibility: a field synopsis and meta-analysis |
| title_sort | single nucleotide polymorphisms and sporadic colorectal cancer susceptibility a field synopsis and meta analysis |
| topic | Non-hereditary colorectal cancer Single nucleotide polymorphisms Field synopsis Meta-analysis |
| url | http://link.springer.com/article/10.1186/s12935-018-0656-2 |
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