High frequency oscillations and high frequency functional network characteristics in the intraoperative electrocorticogram in epilepsy
Objective: High frequency oscillations (HFOs; >80 Hz), especially fast ripples (FRs, 250–500 Hz), are novel biomarkers for epileptogenic tissue. The pathophysiology suggests enhanced functional connectivity within FR generating tissue. Our aim was to determine the relation between brain areas sho...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158216301723 |
| _version_ | 1818128770357264384 |
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| author | W.J.E.M. Zweiphenning M.A. van ‘t Klooster E. van Diessen N.E.C. van Klink G.J.M. Huiskamp T.A. Gebbink F.S.S. Leijten P.H. Gosselaar W.M. Otte C.J. Stam K.P.J. Braun G.J.M. Zijlmans |
| author_facet | W.J.E.M. Zweiphenning M.A. van ‘t Klooster E. van Diessen N.E.C. van Klink G.J.M. Huiskamp T.A. Gebbink F.S.S. Leijten P.H. Gosselaar W.M. Otte C.J. Stam K.P.J. Braun G.J.M. Zijlmans |
| author_sort | W.J.E.M. Zweiphenning |
| collection | DOAJ |
| description | Objective: High frequency oscillations (HFOs; >80 Hz), especially fast ripples (FRs, 250–500 Hz), are novel biomarkers for epileptogenic tissue. The pathophysiology suggests enhanced functional connectivity within FR generating tissue. Our aim was to determine the relation between brain areas showing FRs and ‘baseline’ functional connectivity within EEG networks, especially in the high frequency bands.
Methods: We marked FRs, ripples (80–250 Hz) and spikes in the electrocorticogram of 14 patients with refractory temporal lobe epilepsy. We assessed ‘baseline’ functional connectivity in epochs free of epileptiform events within these recordings, using the phase lag index. We computed the Eigenvector Centrality (EC) per channel in the FR and gamma band network. We compared EC between channels that did or did not show events at other moments in time.
Results: FR-band EC was higher in channels with than without spikes. Gamma-band EC was lower in channels with ripples and FRs.
Conclusions: We confirmed previous findings of functional isolation in the gamma-band and found a first proof of functional integration in the FR-band network of channels covering presumed epileptogenic tissue.
Significance: ‘Baseline’ high-frequency network parameters might help intra-operative recognition of epileptogenic tissue without the need for waiting for events. These findings can increase our understanding of the ‘architecture’ of epileptogenic networks and help unravel the pathophysiology of HFOs. |
| first_indexed | 2024-12-11T07:38:32Z |
| format | Article |
| id | doaj.art-68f46bce2926439c8c5b242adf05ca20 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-11T07:38:32Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-68f46bce2926439c8c5b242adf05ca202022-12-22T01:15:39ZengElsevierNeuroImage: Clinical2213-15822016-01-0112C92893910.1016/j.nicl.2016.09.014High frequency oscillations and high frequency functional network characteristics in the intraoperative electrocorticogram in epilepsyW.J.E.M. Zweiphenning0M.A. van ‘t Klooster1E. van Diessen2N.E.C. van Klink3G.J.M. Huiskamp4T.A. Gebbink5F.S.S. Leijten6P.H. Gosselaar7W.M. Otte8C.J. Stam9K.P.J. Braun10G.J.M. Zijlmans11Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The NetherlandsBrain Center Rudolf Magnus, Department of Neurology and Neurosurgery, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The NetherlandsBrain Center Rudolf Magnus, Department of Pediatric Neurology, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The NetherlandsBrain Center Rudolf Magnus, Department of Neurology and Neurosurgery, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The NetherlandsBrain Center Rudolf Magnus, Department of Neurology and Neurosurgery, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The NetherlandsBrain Center Rudolf Magnus, Department of Neurology and Neurosurgery, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The NetherlandsBrain Center Rudolf Magnus, Department of Neurology and Neurosurgery, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The NetherlandsBrain Center Rudolf Magnus, Department of Neurology and Neurosurgery, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The NetherlandsBrain Center Rudolf Magnus, Department of Pediatric Neurology, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The NetherlandsDepartment of Clinical Neurophysiology, Neuroscience Campus Amsterdam, VU University Medical Center, Postbus 7057, 1007 MB Amsterdam, The NetherlandsBrain Center Rudolf Magnus, Department of Pediatric Neurology, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The NetherlandsBrain Center Rudolf Magnus, Department of Neurology and Neurosurgery, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The NetherlandsObjective: High frequency oscillations (HFOs; >80 Hz), especially fast ripples (FRs, 250–500 Hz), are novel biomarkers for epileptogenic tissue. The pathophysiology suggests enhanced functional connectivity within FR generating tissue. Our aim was to determine the relation between brain areas showing FRs and ‘baseline’ functional connectivity within EEG networks, especially in the high frequency bands. Methods: We marked FRs, ripples (80–250 Hz) and spikes in the electrocorticogram of 14 patients with refractory temporal lobe epilepsy. We assessed ‘baseline’ functional connectivity in epochs free of epileptiform events within these recordings, using the phase lag index. We computed the Eigenvector Centrality (EC) per channel in the FR and gamma band network. We compared EC between channels that did or did not show events at other moments in time. Results: FR-band EC was higher in channels with than without spikes. Gamma-band EC was lower in channels with ripples and FRs. Conclusions: We confirmed previous findings of functional isolation in the gamma-band and found a first proof of functional integration in the FR-band network of channels covering presumed epileptogenic tissue. Significance: ‘Baseline’ high-frequency network parameters might help intra-operative recognition of epileptogenic tissue without the need for waiting for events. These findings can increase our understanding of the ‘architecture’ of epileptogenic networks and help unravel the pathophysiology of HFOs.http://www.sciencedirect.com/science/article/pii/S2213158216301723EpilepsyHigh Frequency OscillationsFunctional network analysisEpileptogenic zoneEpilepsy surgery |
| spellingShingle | W.J.E.M. Zweiphenning M.A. van ‘t Klooster E. van Diessen N.E.C. van Klink G.J.M. Huiskamp T.A. Gebbink F.S.S. Leijten P.H. Gosselaar W.M. Otte C.J. Stam K.P.J. Braun G.J.M. Zijlmans High frequency oscillations and high frequency functional network characteristics in the intraoperative electrocorticogram in epilepsy NeuroImage: Clinical Epilepsy High Frequency Oscillations Functional network analysis Epileptogenic zone Epilepsy surgery |
| title | High frequency oscillations and high frequency functional network characteristics in the intraoperative electrocorticogram in epilepsy |
| title_full | High frequency oscillations and high frequency functional network characteristics in the intraoperative electrocorticogram in epilepsy |
| title_fullStr | High frequency oscillations and high frequency functional network characteristics in the intraoperative electrocorticogram in epilepsy |
| title_full_unstemmed | High frequency oscillations and high frequency functional network characteristics in the intraoperative electrocorticogram in epilepsy |
| title_short | High frequency oscillations and high frequency functional network characteristics in the intraoperative electrocorticogram in epilepsy |
| title_sort | high frequency oscillations and high frequency functional network characteristics in the intraoperative electrocorticogram in epilepsy |
| topic | Epilepsy High Frequency Oscillations Functional network analysis Epileptogenic zone Epilepsy surgery |
| url | http://www.sciencedirect.com/science/article/pii/S2213158216301723 |
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