Crying with depressed affect induced by electrical stimulation of the anterior insula: A stereo EEG case study
Stereo-EEG (sEEG) is an invasive recording technique used to localize the seizure-onset zone for epilepsy surgery in people with drug-resistant focal seizures. Pathological crying reflects disordered emotional expression and the anterior insula is known to play a role in empathy and socio-emotional...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Epilepsy & Behavior Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589986420300691 |
| _version_ | 1819085351846674432 |
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| author | Tarun D. Singh David S. Sabsevitz Nimit N. Desai Erik H. Middlebrooks Anteneh M. Feyissa Sanjeet Grewal Robert E. Wharen William O. Tatum Anthony L. Ritaccio |
| author_facet | Tarun D. Singh David S. Sabsevitz Nimit N. Desai Erik H. Middlebrooks Anteneh M. Feyissa Sanjeet Grewal Robert E. Wharen William O. Tatum Anthony L. Ritaccio |
| author_sort | Tarun D. Singh |
| collection | DOAJ |
| description | Stereo-EEG (sEEG) is an invasive recording technique used to localize the seizure-onset zone for epilepsy surgery in people with drug-resistant focal seizures. Pathological crying reflects disordered emotional expression and the anterior insula is known to play a role in empathy and socio-emotional processing. We describe a patient where electrical stimulation mapping (ESM) of the anterior insula during sEEG generated pathological crying and profound sadness that was time-locked to the electrical stimulus.We evaluated a 35-year-old left-handed female for repeat epilepsy surgery. The patient had drug resistant focal impaired awareness seizures despite a previous left temporal neocortical resection informed by an invasive study using subdural grid and strip electrodes seven years earlier. She was studied invasively with 10 sEEG electrodes sampling temporal, occipital, and insular targets. In the process of functional mapping, stimulation of the anterior insular cortex provoked tearful crying with sad affect, reproducible upon repeat stimulation.Our case is unique in demonstrating transitory pathological crying with profound sadness provoked by ESM of the left anterior insula. Furthermore we demonstrate repeated time-synched crying from electrical stimulation, which supports the hypothesis that the anterior insula in the brain plays an important role in the biology of emotion, as implicated by previous studies. |
| first_indexed | 2024-12-21T21:02:59Z |
| format | Article |
| id | doaj.art-68f58b98e3d54ed196e20030cbd6a297 |
| institution | Directory Open Access Journal |
| issn | 2589-9864 |
| language | English |
| last_indexed | 2024-12-21T21:02:59Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Epilepsy & Behavior Reports |
| spelling | doaj.art-68f58b98e3d54ed196e20030cbd6a2972022-12-21T18:50:23ZengElsevierEpilepsy & Behavior Reports2589-98642021-01-0115100421Crying with depressed affect induced by electrical stimulation of the anterior insula: A stereo EEG case studyTarun D. Singh0David S. Sabsevitz1Nimit N. Desai2Erik H. Middlebrooks3Anteneh M. Feyissa4Sanjeet Grewal5Robert E. Wharen6William O. Tatum7Anthony L. Ritaccio8Department of Neurology, Mayo Clinic, Rochester, MN, USADepartment of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA; Department of Radiology, Mayo Clinic, Jacksonville, FL, USADepartment of Neurology, Mayo Clinic, Jacksonville, FL, USADepartment of Radiology, Mayo Clinic, Jacksonville, FL, USA; Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USADepartment of Neurology, Mayo Clinic, Jacksonville, FL, USADepartment of Neurosurgery, Mayo Clinic, Jacksonville, FL, USADepartment of Neurosurgery, Mayo Clinic, Jacksonville, FL, USADepartment of Neurology, Mayo Clinic, Jacksonville, FL, USADepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA; Corresponding author at: Department of Neurology, Mayo Clinic, Mangurian Bldg., 4th Floor, 4500 San Pablo Road, Jacksonville, FL 32224, USA.Stereo-EEG (sEEG) is an invasive recording technique used to localize the seizure-onset zone for epilepsy surgery in people with drug-resistant focal seizures. Pathological crying reflects disordered emotional expression and the anterior insula is known to play a role in empathy and socio-emotional processing. We describe a patient where electrical stimulation mapping (ESM) of the anterior insula during sEEG generated pathological crying and profound sadness that was time-locked to the electrical stimulus.We evaluated a 35-year-old left-handed female for repeat epilepsy surgery. The patient had drug resistant focal impaired awareness seizures despite a previous left temporal neocortical resection informed by an invasive study using subdural grid and strip electrodes seven years earlier. She was studied invasively with 10 sEEG electrodes sampling temporal, occipital, and insular targets. In the process of functional mapping, stimulation of the anterior insular cortex provoked tearful crying with sad affect, reproducible upon repeat stimulation.Our case is unique in demonstrating transitory pathological crying with profound sadness provoked by ESM of the left anterior insula. Furthermore we demonstrate repeated time-synched crying from electrical stimulation, which supports the hypothesis that the anterior insula in the brain plays an important role in the biology of emotion, as implicated by previous studies.http://www.sciencedirect.com/science/article/pii/S2589986420300691Insular stimulationCryingsEEGAnterior insula |
| spellingShingle | Tarun D. Singh David S. Sabsevitz Nimit N. Desai Erik H. Middlebrooks Anteneh M. Feyissa Sanjeet Grewal Robert E. Wharen William O. Tatum Anthony L. Ritaccio Crying with depressed affect induced by electrical stimulation of the anterior insula: A stereo EEG case study Epilepsy & Behavior Reports Insular stimulation Crying sEEG Anterior insula |
| title | Crying with depressed affect induced by electrical stimulation of the anterior insula: A stereo EEG case study |
| title_full | Crying with depressed affect induced by electrical stimulation of the anterior insula: A stereo EEG case study |
| title_fullStr | Crying with depressed affect induced by electrical stimulation of the anterior insula: A stereo EEG case study |
| title_full_unstemmed | Crying with depressed affect induced by electrical stimulation of the anterior insula: A stereo EEG case study |
| title_short | Crying with depressed affect induced by electrical stimulation of the anterior insula: A stereo EEG case study |
| title_sort | crying with depressed affect induced by electrical stimulation of the anterior insula a stereo eeg case study |
| topic | Insular stimulation Crying sEEG Anterior insula |
| url | http://www.sciencedirect.com/science/article/pii/S2589986420300691 |
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