Bone Marrow Aspirate Concentrate Is More Effective Than Hyaluronic Acid and Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis: A Retrospective Study of 505 Consecutive Patients
The aim of this study was to evaluate and compare the effectiveness of three different intra-articular injective treatments: hyaluronic acid (HA), autologous conditioned serum (ACS) and bone marrow aspirate concentrate (BMAC) for the treatment of knee osteoarthritis (OA). A Level III retrospective c...
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MDPI AG
2021-03-01
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| Online Access: | https://www.mdpi.com/2076-3417/11/7/2932 |
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| author | Mohsen Hussein Carola F. van Eck Nevenka Kregar Velikonja |
| author_facet | Mohsen Hussein Carola F. van Eck Nevenka Kregar Velikonja |
| author_sort | Mohsen Hussein |
| collection | DOAJ |
| description | The aim of this study was to evaluate and compare the effectiveness of three different intra-articular injective treatments: hyaluronic acid (HA), autologous conditioned serum (ACS) and bone marrow aspirate concentrate (BMAC) for the treatment of knee osteoarthritis (OA). A Level III retrospective comparative clinical study was performed on 505 consecutive patients treated with HA (<i>n</i> = 171), ACS (<i>n</i> = 222) or BMAC (<i>n</i> = 112) for knee OA. The mean patient age was 52 ± 13 years; 54.5% were males. Collected data included patient demographics, symptoms, visual analogue scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and radiographic classification of osteoarthritis grade using plain radiographs and advanced imaging. Clinical outcome was assessed at 3 and 12 months post treatment. Significant improvement in VAS and WOMAC was seen for all three treatments at the 3-month follow-up. At 12 months, VAS was improved in all three treatment groups, yet only BMAC sustained the improved WOMAC even in patients with more severe degenerative changes. This study shows that BMAC is more effective than HA and ACS in the treatment of symptomatic knee OA, especially in the patients with more severe degenerative changes. |
| first_indexed | 2024-03-10T12:55:08Z |
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| id | doaj.art-68f5aa2e00ab46639fcc43324b8d6158 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T12:55:08Z |
| publishDate | 2021-03-01 |
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| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-68f5aa2e00ab46639fcc43324b8d61582023-11-21T11:59:06ZengMDPI AGApplied Sciences2076-34172021-03-01117293210.3390/app11072932Bone Marrow Aspirate Concentrate Is More Effective Than Hyaluronic Acid and Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis: A Retrospective Study of 505 Consecutive PatientsMohsen Hussein0Carola F. van Eck1Nevenka Kregar Velikonja2Faculty of Health Sciences, University of Novo Mesto, 8000 Novo Mesto, SloveniaOrthopaedic Engineering & Sports Medicine Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15203, USAFaculty of Health Sciences, University of Novo Mesto, 8000 Novo Mesto, SloveniaThe aim of this study was to evaluate and compare the effectiveness of three different intra-articular injective treatments: hyaluronic acid (HA), autologous conditioned serum (ACS) and bone marrow aspirate concentrate (BMAC) for the treatment of knee osteoarthritis (OA). A Level III retrospective comparative clinical study was performed on 505 consecutive patients treated with HA (<i>n</i> = 171), ACS (<i>n</i> = 222) or BMAC (<i>n</i> = 112) for knee OA. The mean patient age was 52 ± 13 years; 54.5% were males. Collected data included patient demographics, symptoms, visual analogue scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and radiographic classification of osteoarthritis grade using plain radiographs and advanced imaging. Clinical outcome was assessed at 3 and 12 months post treatment. Significant improvement in VAS and WOMAC was seen for all three treatments at the 3-month follow-up. At 12 months, VAS was improved in all three treatment groups, yet only BMAC sustained the improved WOMAC even in patients with more severe degenerative changes. This study shows that BMAC is more effective than HA and ACS in the treatment of symptomatic knee OA, especially in the patients with more severe degenerative changes.https://www.mdpi.com/2076-3417/11/7/2932osteoarthritiskneehyaluronic acidautologous conditioned serumbone marrow aspirate concentrateclinical outcome |
| spellingShingle | Mohsen Hussein Carola F. van Eck Nevenka Kregar Velikonja Bone Marrow Aspirate Concentrate Is More Effective Than Hyaluronic Acid and Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis: A Retrospective Study of 505 Consecutive Patients Applied Sciences osteoarthritis knee hyaluronic acid autologous conditioned serum bone marrow aspirate concentrate clinical outcome |
| title | Bone Marrow Aspirate Concentrate Is More Effective Than Hyaluronic Acid and Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis: A Retrospective Study of 505 Consecutive Patients |
| title_full | Bone Marrow Aspirate Concentrate Is More Effective Than Hyaluronic Acid and Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis: A Retrospective Study of 505 Consecutive Patients |
| title_fullStr | Bone Marrow Aspirate Concentrate Is More Effective Than Hyaluronic Acid and Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis: A Retrospective Study of 505 Consecutive Patients |
| title_full_unstemmed | Bone Marrow Aspirate Concentrate Is More Effective Than Hyaluronic Acid and Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis: A Retrospective Study of 505 Consecutive Patients |
| title_short | Bone Marrow Aspirate Concentrate Is More Effective Than Hyaluronic Acid and Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis: A Retrospective Study of 505 Consecutive Patients |
| title_sort | bone marrow aspirate concentrate is more effective than hyaluronic acid and autologous conditioned serum in the treatment of knee osteoarthritis a retrospective study of 505 consecutive patients |
| topic | osteoarthritis knee hyaluronic acid autologous conditioned serum bone marrow aspirate concentrate clinical outcome |
| url | https://www.mdpi.com/2076-3417/11/7/2932 |
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