Association of Circulating Carbohydrate Antigen 19-9 Level with Type 2 Diabetic Kidney Disease in Chinese Adults: A Cross-Sectional Study
Pijun Yan,1– 5 Jia Li,1– 5 Yi Zhang,1– 5 Xiaofang Dan,1– 5 Xian Wu,1– 5 Xing Zhang,1– 5 Yuxia Yang,1– 5 Xiping Chen,6 Shengxi Li,6 Pan Chen,1– 5 Qin Wan,1– 5 Yong Xu1– 5 1Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-01-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/association-of-circulating-carbohydrate-antigen-19-9-level-with-type-2-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1797335782062555136 |
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| author | Yan P Li J Zhang Y Dan X Wu X Zhang X Yang Y Chen X Li S Chen P Wan Q Xu Y |
| author_facet | Yan P Li J Zhang Y Dan X Wu X Zhang X Yang Y Chen X Li S Chen P Wan Q Xu Y |
| author_sort | Yan P |
| collection | DOAJ |
| description | Pijun Yan,1– 5 Jia Li,1– 5 Yi Zhang,1– 5 Xiaofang Dan,1– 5 Xian Wu,1– 5 Xing Zhang,1– 5 Yuxia Yang,1– 5 Xiping Chen,6 Shengxi Li,6 Pan Chen,1– 5 Qin Wan,1– 5 Yong Xu1– 5 1Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China; 2Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, People’s Republic of China; 3Sichuan Clinical Research Center for Diabetes and Metabolism, Luzhou, People’s Republic of China; 4Sichuan Clinical Research Center for Nephropathy, Luzhou, People’s Republic of China; 5Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, People’s Republic of China; 6Clinical medical College, Southwest Medical University, Luzhou, People’s Republic of ChinaCorrespondence: Pijun Yan, Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China, Tel/Fax +86-830-3165361, Email peter2007110361@126.comObjective: Very few and conflicting data are available regarding the correlation between circulating carbohydrate antigen 19-9 (CA19-9) levels and diabetic kidney disease (DKD) and its components including albuminuria and a low estimated glomerular filtration rate (eGFR). This study aimed to examine the association of circulating CA19-9 and DKD in Chinese patients with type 2 diabetes mellitus (T2DM).Methods: A total of 402 hospitalized T2DM patients between September 2017 and December 2021 were included in this cross-sectional study. There were 224 and 178 subjects in non-DKD and DKD groups, respectively. Serum CA19-9 was measured by chemiluminescence method, and its potential relationship with DKD was evaluated by multivariate logistic regression and correlation analyses, and receiver operating characteristic (ROC) curve analysis.Results: T2DM patients with DKD had significantly higher serum CA19-9 levels than those without, and serum CA19-9 levels were positively related to urinary albumin-to-creatinine ratio and negatively to eGFR (P< 0.01). Multivariate regression analysis revealed that serum CA 19-9 was an independent factor of DKD [odds ratio (OR), 1.018; 95% confidence interval (CI), 1.002– 1.035; P< 0.05]. Moreover, an increased progressively risk of DKD with an increase in serum CA19-9 quartiles was observed (P for trend < 0.001), and T2DM patients in the highest serum CA19-9 quartile were associated with an increased likelihood of DKD when compared to those in the lowest quartile (OR: 2.936, 95% CI 1.129– 7.633, P< 0.05). Last, the analysis of ROC curves suggested that serum CA 19-9 at a cut of 25.09 U/mL resulted in the highest Youden index with sensitivity 43.8% and 75.4% specificity to predict the presence of DKD.Conclusion: These results showed that high circulating CA19-9 was related to DKD and may serve as a useful biomarker of DKD in hospitalized Chinese T2DM patients.Keywords: carbohydrate antigen 19-9, urinary albumin-to-creatinine ratio, diabetic kidney disease, estimated glomerular filtration rate, Chinese population |
| first_indexed | 2024-03-08T08:42:19Z |
| format | Article |
| id | doaj.art-68f5abd2191845d880d74b812f0bcb6c |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-03-08T08:42:19Z |
| publishDate | 2024-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-68f5abd2191845d880d74b812f0bcb6c2024-02-01T17:59:27ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072024-01-01Volume 1746747790063Association of Circulating Carbohydrate Antigen 19-9 Level with Type 2 Diabetic Kidney Disease in Chinese Adults: A Cross-Sectional StudyYan PLi JZhang YDan XWu XZhang XYang YChen XLi SChen PWan QXu YPijun Yan,1– 5 Jia Li,1– 5 Yi Zhang,1– 5 Xiaofang Dan,1– 5 Xian Wu,1– 5 Xing Zhang,1– 5 Yuxia Yang,1– 5 Xiping Chen,6 Shengxi Li,6 Pan Chen,1– 5 Qin Wan,1– 5 Yong Xu1– 5 1Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China; 2Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, People’s Republic of China; 3Sichuan Clinical Research Center for Diabetes and Metabolism, Luzhou, People’s Republic of China; 4Sichuan Clinical Research Center for Nephropathy, Luzhou, People’s Republic of China; 5Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, People’s Republic of China; 6Clinical medical College, Southwest Medical University, Luzhou, People’s Republic of ChinaCorrespondence: Pijun Yan, Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China, Tel/Fax +86-830-3165361, Email peter2007110361@126.comObjective: Very few and conflicting data are available regarding the correlation between circulating carbohydrate antigen 19-9 (CA19-9) levels and diabetic kidney disease (DKD) and its components including albuminuria and a low estimated glomerular filtration rate (eGFR). This study aimed to examine the association of circulating CA19-9 and DKD in Chinese patients with type 2 diabetes mellitus (T2DM).Methods: A total of 402 hospitalized T2DM patients between September 2017 and December 2021 were included in this cross-sectional study. There were 224 and 178 subjects in non-DKD and DKD groups, respectively. Serum CA19-9 was measured by chemiluminescence method, and its potential relationship with DKD was evaluated by multivariate logistic regression and correlation analyses, and receiver operating characteristic (ROC) curve analysis.Results: T2DM patients with DKD had significantly higher serum CA19-9 levels than those without, and serum CA19-9 levels were positively related to urinary albumin-to-creatinine ratio and negatively to eGFR (P< 0.01). Multivariate regression analysis revealed that serum CA 19-9 was an independent factor of DKD [odds ratio (OR), 1.018; 95% confidence interval (CI), 1.002– 1.035; P< 0.05]. Moreover, an increased progressively risk of DKD with an increase in serum CA19-9 quartiles was observed (P for trend < 0.001), and T2DM patients in the highest serum CA19-9 quartile were associated with an increased likelihood of DKD when compared to those in the lowest quartile (OR: 2.936, 95% CI 1.129– 7.633, P< 0.05). Last, the analysis of ROC curves suggested that serum CA 19-9 at a cut of 25.09 U/mL resulted in the highest Youden index with sensitivity 43.8% and 75.4% specificity to predict the presence of DKD.Conclusion: These results showed that high circulating CA19-9 was related to DKD and may serve as a useful biomarker of DKD in hospitalized Chinese T2DM patients.Keywords: carbohydrate antigen 19-9, urinary albumin-to-creatinine ratio, diabetic kidney disease, estimated glomerular filtration rate, Chinese populationhttps://www.dovepress.com/association-of-circulating-carbohydrate-antigen-19-9-level-with-type-2-peer-reviewed-fulltext-article-DMSOcarbohydrate antigen 19-9urinary albumin-to- creatinine ratiodiabetic kidney diseaseestimated glomerular filtration ratechinese population |
| spellingShingle | Yan P Li J Zhang Y Dan X Wu X Zhang X Yang Y Chen X Li S Chen P Wan Q Xu Y Association of Circulating Carbohydrate Antigen 19-9 Level with Type 2 Diabetic Kidney Disease in Chinese Adults: A Cross-Sectional Study Diabetes, Metabolic Syndrome and Obesity carbohydrate antigen 19-9 urinary albumin-to- creatinine ratio diabetic kidney disease estimated glomerular filtration rate chinese population |
| title | Association of Circulating Carbohydrate Antigen 19-9 Level with Type 2 Diabetic Kidney Disease in Chinese Adults: A Cross-Sectional Study |
| title_full | Association of Circulating Carbohydrate Antigen 19-9 Level with Type 2 Diabetic Kidney Disease in Chinese Adults: A Cross-Sectional Study |
| title_fullStr | Association of Circulating Carbohydrate Antigen 19-9 Level with Type 2 Diabetic Kidney Disease in Chinese Adults: A Cross-Sectional Study |
| title_full_unstemmed | Association of Circulating Carbohydrate Antigen 19-9 Level with Type 2 Diabetic Kidney Disease in Chinese Adults: A Cross-Sectional Study |
| title_short | Association of Circulating Carbohydrate Antigen 19-9 Level with Type 2 Diabetic Kidney Disease in Chinese Adults: A Cross-Sectional Study |
| title_sort | association of circulating carbohydrate antigen 19 9 level with type 2 diabetic kidney disease in chinese adults a cross sectional study |
| topic | carbohydrate antigen 19-9 urinary albumin-to- creatinine ratio diabetic kidney disease estimated glomerular filtration rate chinese population |
| url | https://www.dovepress.com/association-of-circulating-carbohydrate-antigen-19-9-level-with-type-2-peer-reviewed-fulltext-article-DMSO |
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