Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis
Abstract Background Fatty acids have diverse immunomodulatory functions and the potential to be associated with inflammatory responses in sarcoidosis. Methods The serum levels of multiple long-chain fatty acids (LCFAs) were compared between 63 patients with sarcoidosis and 38 healthy controls. The a...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-022-02084-x |
| _version_ | 1818162793680994304 |
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| author | Takahito Suzuki Masato Karayama Yusuke Inoue Hironao Hozumi Yuzo Suzuki Kazuki Furuhashi Tomoyuki Fujisawa Noriyuki Enomoto Yutaro Nakamura Naoki Inui Takafumi Suda |
| author_facet | Takahito Suzuki Masato Karayama Yusuke Inoue Hironao Hozumi Yuzo Suzuki Kazuki Furuhashi Tomoyuki Fujisawa Noriyuki Enomoto Yutaro Nakamura Naoki Inui Takafumi Suda |
| author_sort | Takahito Suzuki |
| collection | DOAJ |
| description | Abstract Background Fatty acids have diverse immunomodulatory functions and the potential to be associated with inflammatory responses in sarcoidosis. Methods The serum levels of multiple long-chain fatty acids (LCFAs) were compared between 63 patients with sarcoidosis and 38 healthy controls. The associations of LCFAs with clinical outcomes of sarcoidosis were also evaluated. Results The patients with sarcoidosis had significantly lower levels of n-3 poly-unsaturated fatty acids (PUFAs) (p < 0.001) and n-6 PUFAs (p < 0.001) than the healthy controls. However, there were no significant differences in the levels of saturated fatty acids (SFAs) and mono-unsaturated fatty acids (MUFAs) between the two groups. On multivariate logistic analysis, lower levels of n-3 PUFAs, n-6 PUFAs, and n-3/n-6 ratio were predictive of sarcoidosis. Among the patients with sarcoidosis, those with multiple organ involvement had significantly lower levels of n-3 PUFAs and n-3/n-6 ratio than those with single organ involvement. There were no significant differences in the levels of n-6 PUFAs, SFAs, and MUFAs between the patients with multiple and single organ involvement. On multivariate logistic analysis, lower levels of SFAs and n-3/n-6 ratio were predictive of multiple organ involvement. The levels of LCFAs had no significant association with radiographic stage or spontaneous remission. Conclusions Assessment of LCFA profiles may be useful for the diagnosis of sarcoidosis and evaluation of the disease activity. |
| first_indexed | 2024-12-11T16:39:19Z |
| format | Article |
| id | doaj.art-68f758619b9245cfb4767be76afb3cd1 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-11T16:39:19Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-68f758619b9245cfb4767be76afb3cd12022-12-22T00:58:22ZengBMCBMC Pulmonary Medicine1471-24662022-07-012211910.1186/s12890-022-02084-xAssociations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosisTakahito Suzuki0Masato Karayama1Yusuke Inoue2Hironao Hozumi3Yuzo Suzuki4Kazuki Furuhashi5Tomoyuki Fujisawa6Noriyuki Enomoto7Yutaro Nakamura8Naoki Inui9Takafumi Suda10Second Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineDepartment of Clinical Pharmacology and Therapeutics, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineAbstract Background Fatty acids have diverse immunomodulatory functions and the potential to be associated with inflammatory responses in sarcoidosis. Methods The serum levels of multiple long-chain fatty acids (LCFAs) were compared between 63 patients with sarcoidosis and 38 healthy controls. The associations of LCFAs with clinical outcomes of sarcoidosis were also evaluated. Results The patients with sarcoidosis had significantly lower levels of n-3 poly-unsaturated fatty acids (PUFAs) (p < 0.001) and n-6 PUFAs (p < 0.001) than the healthy controls. However, there were no significant differences in the levels of saturated fatty acids (SFAs) and mono-unsaturated fatty acids (MUFAs) between the two groups. On multivariate logistic analysis, lower levels of n-3 PUFAs, n-6 PUFAs, and n-3/n-6 ratio were predictive of sarcoidosis. Among the patients with sarcoidosis, those with multiple organ involvement had significantly lower levels of n-3 PUFAs and n-3/n-6 ratio than those with single organ involvement. There were no significant differences in the levels of n-6 PUFAs, SFAs, and MUFAs between the patients with multiple and single organ involvement. On multivariate logistic analysis, lower levels of SFAs and n-3/n-6 ratio were predictive of multiple organ involvement. The levels of LCFAs had no significant association with radiographic stage or spontaneous remission. Conclusions Assessment of LCFA profiles may be useful for the diagnosis of sarcoidosis and evaluation of the disease activity.https://doi.org/10.1186/s12890-022-02084-xLipidMetabolitesomega-3 fatty acidsomega-6 fatty acidsImmune metabolism |
| spellingShingle | Takahito Suzuki Masato Karayama Yusuke Inoue Hironao Hozumi Yuzo Suzuki Kazuki Furuhashi Tomoyuki Fujisawa Noriyuki Enomoto Yutaro Nakamura Naoki Inui Takafumi Suda Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis BMC Pulmonary Medicine Lipid Metabolites omega-3 fatty acids omega-6 fatty acids Immune metabolism |
| title | Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis |
| title_full | Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis |
| title_fullStr | Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis |
| title_full_unstemmed | Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis |
| title_short | Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis |
| title_sort | associations of serum long chain fatty acids with multiple organ involvement in patients with sarcoidosis |
| topic | Lipid Metabolites omega-3 fatty acids omega-6 fatty acids Immune metabolism |
| url | https://doi.org/10.1186/s12890-022-02084-x |
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