Evaluation of 4-Aminoquinoline Hydrazone Analogues as Potential Leads for Drug-Resistant Malaria

Evaluation of 4-Aminoquinoline Hydrazone Analogues as Potential Leads for Drug-Resistant Malaria

The emergence of resistance to first-line antimalarial drugs calls for the development of new therapies for drug-resistant malaria. The efficacy of quinoline-based antimalarial drugs has prompted the development of novel quinolines. A panel of 4-aminoquinoline hydrazone analogues were tested on the...

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Bibliographic Details
Main Authors: Rachael N. Magwaza, Muna Abubaker, Buthaina Hussain, Michael Haley, Kevin Couper, Sally Freeman, Niroshini J. Nirmalan
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Molecules
Subjects:
4-aminoquinoline
hydrazone
antimalarial
NQO2 inhibitors
antimalarial drug interaction
SAR
Online Access:https://www.mdpi.com/1420-3049/28/18/6471

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