Indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma
Marcelo Ayala,1–3 Filip Cuklev41Eye Department, Skaraborg Hospital, Skövde, Sweden; 2Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; 3Karolinska Institute, Solna, Sweden; 4TATAA Biocenter, Gothenburg, SwedenBackground: Glaucoma is an optic neuropathy associated wit...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2018-07-01
|
| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/indistinguishable-gene-expression-between-healthy-eyes-and-eyes-with-u-peer-reviewed-article-OPTH |
| _version_ | 1818684218363871232 |
|---|---|
| author | Ayala M Cuklev F |
| author_facet | Ayala M Cuklev F |
| author_sort | Ayala M |
| collection | DOAJ |
| description | Marcelo Ayala,1–3 Filip Cuklev41Eye Department, Skaraborg Hospital, Skövde, Sweden; 2Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; 3Karolinska Institute, Solna, Sweden; 4TATAA Biocenter, Gothenburg, SwedenBackground: Glaucoma is an optic neuropathy associated with visual field loss. There are different types of glaucoma, among them exfoliative glaucoma. Glaucoma can present as unilateral or bilateral. The present study aimed to show the association between gene expression and exfoliation in unilateral glaucoma cases.Methods: Included patients were suffering from exfoliative glaucoma in one eye, meanwhile the other eye was healthy and used as a control. Lens capsule and conjunctival biopsies were taken from both eyes. Gene expression was analyzed.Results: Both groups were completely different at baseline regarding intraocular pressure, visual acuity before the operation, visual field damage, optic nerve damage, etc. As for gene expression, the only significant difference was found in CYP1B1 from lens capsules. None of the other genes studied showed differential expression in either lens capsules or conjunctival biopsies.Conclusion: No difference in gene expression was found between eyes with and without exfoliative glaucoma. Exfoliative glaucoma seems to be a bilateral disease, though the phenotype is not always clinically present.Keywords: exfoliation, glaucoma, gene expression, unilateral |
| first_indexed | 2024-12-17T10:47:08Z |
| format | Article |
| id | doaj.art-68f851524a7443ecbe62ef463f865b84 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-17T10:47:08Z |
| publishDate | 2018-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-68f851524a7443ecbe62ef463f865b842022-12-21T21:52:05ZengDove Medical PressClinical Ophthalmology1177-54832018-07-01Volume 121155116239363Indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucomaAyala MCuklev FMarcelo Ayala,1–3 Filip Cuklev41Eye Department, Skaraborg Hospital, Skövde, Sweden; 2Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; 3Karolinska Institute, Solna, Sweden; 4TATAA Biocenter, Gothenburg, SwedenBackground: Glaucoma is an optic neuropathy associated with visual field loss. There are different types of glaucoma, among them exfoliative glaucoma. Glaucoma can present as unilateral or bilateral. The present study aimed to show the association between gene expression and exfoliation in unilateral glaucoma cases.Methods: Included patients were suffering from exfoliative glaucoma in one eye, meanwhile the other eye was healthy and used as a control. Lens capsule and conjunctival biopsies were taken from both eyes. Gene expression was analyzed.Results: Both groups were completely different at baseline regarding intraocular pressure, visual acuity before the operation, visual field damage, optic nerve damage, etc. As for gene expression, the only significant difference was found in CYP1B1 from lens capsules. None of the other genes studied showed differential expression in either lens capsules or conjunctival biopsies.Conclusion: No difference in gene expression was found between eyes with and without exfoliative glaucoma. Exfoliative glaucoma seems to be a bilateral disease, though the phenotype is not always clinically present.Keywords: exfoliation, glaucoma, gene expression, unilateralhttps://www.dovepress.com/indistinguishable-gene-expression-between-healthy-eyes-and-eyes-with-u-peer-reviewed-article-OPTHexfoliationglaucomagene expressionunilateral. |
| spellingShingle | Ayala M Cuklev F Indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma Clinical Ophthalmology exfoliation glaucoma gene expression unilateral. |
| title | Indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma |
| title_full | Indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma |
| title_fullStr | Indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma |
| title_full_unstemmed | Indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma |
| title_short | Indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma |
| title_sort | indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma |
| topic | exfoliation glaucoma gene expression unilateral. |
| url | https://www.dovepress.com/indistinguishable-gene-expression-between-healthy-eyes-and-eyes-with-u-peer-reviewed-article-OPTH |
| work_keys_str_mv | AT ayalam indistinguishablegeneexpressionbetweenhealthyeyesandeyeswithunilateralexfoliativeglaucoma AT cuklevf indistinguishablegeneexpressionbetweenhealthyeyesandeyeswithunilateralexfoliativeglaucoma |