Primary ovarian serous carcinomas with extensive squamous differentiation: a case report and literature review
Abstract Background Primary ovarian serous carcinomas (OSC) with extensive squamous differentiation is a rare, and histological diagnostic criteria and biological behavior have not been fully established. We present an extremely rare case of primary OSC of the ovary with squamous differentiation. Ca...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | BMC Women's Health |
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| Online Access: | https://doi.org/10.1186/s12905-021-01336-y |
| _version_ | 1818676352661848064 |
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| author | Yao Sun Yuezhou Chen Xiaofei Zhang Hao Chen Feng Zhou |
| author_facet | Yao Sun Yuezhou Chen Xiaofei Zhang Hao Chen Feng Zhou |
| author_sort | Yao Sun |
| collection | DOAJ |
| description | Abstract Background Primary ovarian serous carcinomas (OSC) with extensive squamous differentiation is a rare, and histological diagnostic criteria and biological behavior have not been fully established. We present an extremely rare case of primary OSC of the ovary with squamous differentiation. Case presentation A 58-year-old (gravidity 3, parity 2) female was admitted complaining of abdominal distention for 6 months. No apparent tumor in the cervix was found by a physical examination. Serum levels of cancer antigen 125 (CA125) was elevated (2723.0 IU/L). Macroscopically, a 7 cm tumor of the left uterine adnexa, a 5 cm tumor of the right adnexa, and a 3 cm tumor of the omentum were found. Histological and immunochemical tests confirmed a diagnosis of OSC with squamous differentiation. Debulking surgery with tumor resection was performed. The patient was subsequently received postoperative chemotherapy. Conclusions In summary, OSC with extensive squamous differentiation is a rare, and the inter- and intratumor heterogeneity may be the reason for this phenomenon. Histological diagnostic criteria and biological behavior have not been fully established because of the limited data. |
| first_indexed | 2024-12-17T08:42:07Z |
| format | Article |
| id | doaj.art-68f95ec6173a48c194703654b386913b |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-12-17T08:42:07Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-68f95ec6173a48c194703654b386913b2022-12-21T21:56:18ZengBMCBMC Women's Health1472-68742021-05-012111410.1186/s12905-021-01336-yPrimary ovarian serous carcinomas with extensive squamous differentiation: a case report and literature reviewYao Sun0Yuezhou Chen1Xiaofei Zhang2Hao Chen3Feng Zhou4Department of Pathology, School of Medicine, Women’s Hospital, Zhejiang UniversityDepartment of Reproductive and Genetic Medicine Center, The Fifth Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Pathology, School of Medicine, Women’s Hospital, Zhejiang UniversityDepartment of Pathology, University of Texas Southwestern Medical CenterDepartment of Pathology, School of Medicine, Women’s Hospital, Zhejiang UniversityAbstract Background Primary ovarian serous carcinomas (OSC) with extensive squamous differentiation is a rare, and histological diagnostic criteria and biological behavior have not been fully established. We present an extremely rare case of primary OSC of the ovary with squamous differentiation. Case presentation A 58-year-old (gravidity 3, parity 2) female was admitted complaining of abdominal distention for 6 months. No apparent tumor in the cervix was found by a physical examination. Serum levels of cancer antigen 125 (CA125) was elevated (2723.0 IU/L). Macroscopically, a 7 cm tumor of the left uterine adnexa, a 5 cm tumor of the right adnexa, and a 3 cm tumor of the omentum were found. Histological and immunochemical tests confirmed a diagnosis of OSC with squamous differentiation. Debulking surgery with tumor resection was performed. The patient was subsequently received postoperative chemotherapy. Conclusions In summary, OSC with extensive squamous differentiation is a rare, and the inter- and intratumor heterogeneity may be the reason for this phenomenon. Histological diagnostic criteria and biological behavior have not been fully established because of the limited data.https://doi.org/10.1186/s12905-021-01336-yOvarySerous carcinomaSquamous differentiation |
| spellingShingle | Yao Sun Yuezhou Chen Xiaofei Zhang Hao Chen Feng Zhou Primary ovarian serous carcinomas with extensive squamous differentiation: a case report and literature review BMC Women's Health Ovary Serous carcinoma Squamous differentiation |
| title | Primary ovarian serous carcinomas with extensive squamous differentiation: a case report and literature review |
| title_full | Primary ovarian serous carcinomas with extensive squamous differentiation: a case report and literature review |
| title_fullStr | Primary ovarian serous carcinomas with extensive squamous differentiation: a case report and literature review |
| title_full_unstemmed | Primary ovarian serous carcinomas with extensive squamous differentiation: a case report and literature review |
| title_short | Primary ovarian serous carcinomas with extensive squamous differentiation: a case report and literature review |
| title_sort | primary ovarian serous carcinomas with extensive squamous differentiation a case report and literature review |
| topic | Ovary Serous carcinoma Squamous differentiation |
| url | https://doi.org/10.1186/s12905-021-01336-y |
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