One health clones of multidrug-resistant Escherichia coli carried by synanthropic animals in Brazil
WHO priority pathogens have disseminated beyond hospital settings and are now being detected in urban and wild animals worldwide. In this regard, synanthropic animals such as urban pigeons (Columba livia) and rodents (Rattus rattus, Rattus norvegicus and Mus musculus) are of interest to public healt...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | One Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352771422001082 |
| _version_ | 1797805826516189184 |
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| author | Elder Sano Fernanda Esposito Herrison Fontana Bruna Fuga Adriana Cardenas-Arias Quézia Moura Brenda Cardoso Gladyston C.V. Costa Tatiana C.M. Bosqueiro Juliana A. Sinhorini Eduardo de Masi Caroline C. Aires Nilton Lincopan |
| author_facet | Elder Sano Fernanda Esposito Herrison Fontana Bruna Fuga Adriana Cardenas-Arias Quézia Moura Brenda Cardoso Gladyston C.V. Costa Tatiana C.M. Bosqueiro Juliana A. Sinhorini Eduardo de Masi Caroline C. Aires Nilton Lincopan |
| author_sort | Elder Sano |
| collection | DOAJ |
| description | WHO priority pathogens have disseminated beyond hospital settings and are now being detected in urban and wild animals worldwide. In this regard, synanthropic animals such as urban pigeons (Columba livia) and rodents (Rattus rattus, Rattus norvegicus and Mus musculus) are of interest to public health due to their role as reservoirs of pathogens that can cause severe diseases. These animals usually live in highly contaminated environments and have frequent interactions with humans, domestic animals, and food chain, becoming sentinels of anthropogenic activities. In this study, we report genomic data of Escherichia coli strains selected for ceftriaxone and ciprofloxacin resistance, isolated from pigeons and black rats. Genomic analysis revealed the occurrence of international clones belonging to ST10, ST155, ST224 and ST457, carrying a broad resistome to beta-lactams, aminoglycosides, trimethoprim/sulfamethoxazole, fluoroquinolones, tetracyclines and/or phenicols. SNP-based phylogenomic investigation confirmed clonal relatedness with high-risk lineages circulating at the human-animal-environmental interface globally. Our results confirm the dissemination of WHO priority CTX-M-positive E. coli in urban rodents and pigeons in Brazil, highlighting potential of these animals as infection sources and hotspot for dissemination of clinically relevant pathogens and their resistance genes, which is a critical issue within a One Health perspective. |
| first_indexed | 2024-03-13T05:57:56Z |
| format | Article |
| id | doaj.art-68faebf10c434513858498db449827c8 |
| institution | Directory Open Access Journal |
| issn | 2352-7714 |
| language | English |
| last_indexed | 2024-03-13T05:57:56Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | One Health |
| spelling | doaj.art-68faebf10c434513858498db449827c82023-06-13T04:12:13ZengElsevierOne Health2352-77142023-06-0116100476One health clones of multidrug-resistant Escherichia coli carried by synanthropic animals in BrazilElder Sano0Fernanda Esposito1Herrison Fontana2Bruna Fuga3Adriana Cardenas-Arias4Quézia Moura5Brenda Cardoso6Gladyston C.V. Costa7Tatiana C.M. Bosqueiro8Juliana A. Sinhorini9Eduardo de Masi10Caroline C. Aires11Nilton Lincopan12Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Zoonoses Surveillance Division, Health Surveillance Coordination, Municipal Health Department, São Paulo, Brazil; One Health Brazilian Resistance Project (OneBR), Brazil; Corresponding authors at: Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.One Health Brazilian Resistance Project (OneBR), Brazil; Department of Clinical Analysis, School of Pharmacy, University of São Paulo, São Paulo, BrazilOne Health Brazilian Resistance Project (OneBR), Brazil; Department of Clinical Analysis, School of Pharmacy, University of São Paulo, São Paulo, BrazilDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; One Health Brazilian Resistance Project (OneBR), BrazilDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; One Health Brazilian Resistance Project (OneBR), BrazilFederal Institute of Espírito Santo, Vila Velha, BrazilDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; One Health Brazilian Resistance Project (OneBR), BrazilZoonoses Surveillance Division, Health Surveillance Coordination, Municipal Health Department, São Paulo, BrazilZoonoses Surveillance Division, Health Surveillance Coordination, Municipal Health Department, São Paulo, BrazilZoonoses Surveillance Division, Health Surveillance Coordination, Municipal Health Department, São Paulo, BrazilZoonoses Surveillance Division, Health Surveillance Coordination, Municipal Health Department, São Paulo, BrazilZoonoses Surveillance Division, Health Surveillance Coordination, Municipal Health Department, São Paulo, BrazilDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; One Health Brazilian Resistance Project (OneBR), Brazil; Department of Clinical Analysis, School of Pharmacy, University of São Paulo, São Paulo, Brazil; Corresponding authors at: Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.WHO priority pathogens have disseminated beyond hospital settings and are now being detected in urban and wild animals worldwide. In this regard, synanthropic animals such as urban pigeons (Columba livia) and rodents (Rattus rattus, Rattus norvegicus and Mus musculus) are of interest to public health due to their role as reservoirs of pathogens that can cause severe diseases. These animals usually live in highly contaminated environments and have frequent interactions with humans, domestic animals, and food chain, becoming sentinels of anthropogenic activities. In this study, we report genomic data of Escherichia coli strains selected for ceftriaxone and ciprofloxacin resistance, isolated from pigeons and black rats. Genomic analysis revealed the occurrence of international clones belonging to ST10, ST155, ST224 and ST457, carrying a broad resistome to beta-lactams, aminoglycosides, trimethoprim/sulfamethoxazole, fluoroquinolones, tetracyclines and/or phenicols. SNP-based phylogenomic investigation confirmed clonal relatedness with high-risk lineages circulating at the human-animal-environmental interface globally. Our results confirm the dissemination of WHO priority CTX-M-positive E. coli in urban rodents and pigeons in Brazil, highlighting potential of these animals as infection sources and hotspot for dissemination of clinically relevant pathogens and their resistance genes, which is a critical issue within a One Health perspective.http://www.sciencedirect.com/science/article/pii/S2352771422001082EnterobacteralesAntimicrobial resistanceESBLResistomeUrban wildlifeRats |
| spellingShingle | Elder Sano Fernanda Esposito Herrison Fontana Bruna Fuga Adriana Cardenas-Arias Quézia Moura Brenda Cardoso Gladyston C.V. Costa Tatiana C.M. Bosqueiro Juliana A. Sinhorini Eduardo de Masi Caroline C. Aires Nilton Lincopan One health clones of multidrug-resistant Escherichia coli carried by synanthropic animals in Brazil One Health Enterobacterales Antimicrobial resistance ESBL Resistome Urban wildlife Rats |
| title | One health clones of multidrug-resistant Escherichia coli carried by synanthropic animals in Brazil |
| title_full | One health clones of multidrug-resistant Escherichia coli carried by synanthropic animals in Brazil |
| title_fullStr | One health clones of multidrug-resistant Escherichia coli carried by synanthropic animals in Brazil |
| title_full_unstemmed | One health clones of multidrug-resistant Escherichia coli carried by synanthropic animals in Brazil |
| title_short | One health clones of multidrug-resistant Escherichia coli carried by synanthropic animals in Brazil |
| title_sort | one health clones of multidrug resistant escherichia coli carried by synanthropic animals in brazil |
| topic | Enterobacterales Antimicrobial resistance ESBL Resistome Urban wildlife Rats |
| url | http://www.sciencedirect.com/science/article/pii/S2352771422001082 |
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