Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives
Stroke is the second leading cause of death and a major contributor to disability worldwide. The prevalence of stroke is highest in developing countries, with ischemic stroke being the most common type. Considerable progress has been made in our understanding of the pathophysiology of stroke and the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/20/7609 |
| _version_ | 1797550932712488960 |
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| author | Diji Kuriakose Zhicheng Xiao |
| author_facet | Diji Kuriakose Zhicheng Xiao |
| author_sort | Diji Kuriakose |
| collection | DOAJ |
| description | Stroke is the second leading cause of death and a major contributor to disability worldwide. The prevalence of stroke is highest in developing countries, with ischemic stroke being the most common type. Considerable progress has been made in our understanding of the pathophysiology of stroke and the underlying mechanisms leading to ischemic insult. Stroke therapy primarily focuses on restoring blood flow to the brain and treating stroke-induced neurological damage. Lack of success in recent clinical trials has led to significant refinement of animal models, focus-driven study design and use of new technologies in stroke research. Simultaneously, despite progress in stroke management, post-stroke care exerts a substantial impact on families, the healthcare system and the economy. Improvements in pre-clinical and clinical care are likely to underpin successful stroke treatment, recovery, rehabilitation and prevention. In this review, we focus on the pathophysiology of stroke, major advances in the identification of therapeutic targets and recent trends in stroke research. |
| first_indexed | 2024-03-10T15:37:27Z |
| format | Article |
| id | doaj.art-68fb3783dad243e9a0d0b52a64149c17 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:37:27Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-68fb3783dad243e9a0d0b52a64149c172023-11-20T17:08:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012120760910.3390/ijms21207609Pathophysiology and Treatment of Stroke: Present Status and Future PerspectivesDiji Kuriakose0Zhicheng Xiao1Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC 3800, AustraliaDevelopment and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC 3800, AustraliaStroke is the second leading cause of death and a major contributor to disability worldwide. The prevalence of stroke is highest in developing countries, with ischemic stroke being the most common type. Considerable progress has been made in our understanding of the pathophysiology of stroke and the underlying mechanisms leading to ischemic insult. Stroke therapy primarily focuses on restoring blood flow to the brain and treating stroke-induced neurological damage. Lack of success in recent clinical trials has led to significant refinement of animal models, focus-driven study design and use of new technologies in stroke research. Simultaneously, despite progress in stroke management, post-stroke care exerts a substantial impact on families, the healthcare system and the economy. Improvements in pre-clinical and clinical care are likely to underpin successful stroke treatment, recovery, rehabilitation and prevention. In this review, we focus on the pathophysiology of stroke, major advances in the identification of therapeutic targets and recent trends in stroke research.https://www.mdpi.com/1422-0067/21/20/7609strokepathophysiologytreatmentneurological deficitrecoveryrehabilitation |
| spellingShingle | Diji Kuriakose Zhicheng Xiao Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives International Journal of Molecular Sciences stroke pathophysiology treatment neurological deficit recovery rehabilitation |
| title | Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives |
| title_full | Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives |
| title_fullStr | Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives |
| title_full_unstemmed | Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives |
| title_short | Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives |
| title_sort | pathophysiology and treatment of stroke present status and future perspectives |
| topic | stroke pathophysiology treatment neurological deficit recovery rehabilitation |
| url | https://www.mdpi.com/1422-0067/21/20/7609 |
| work_keys_str_mv | AT dijikuriakose pathophysiologyandtreatmentofstrokepresentstatusandfutureperspectives AT zhichengxiao pathophysiologyandtreatmentofstrokepresentstatusandfutureperspectives |