Comprehensive analysis of the clinical and biological significances of cholesterol metabolism in lower-grade gliomas
Abstract Background As a component of membrane lipids and the precursor of oxysterols and steroid hormones, reprogrammed cholesterol metabolism contributes to the initiation and progression of multiple cancers. Thus, we aim to further investigate the significances of cholesterol metabolism in lower-...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-023-10897-0 |
| _version_ | 1827890386083774464 |
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| author | Rui Tao Ruoyu Huang Jingchen Yang Jiangfei Wang Kuanyu Wang |
| author_facet | Rui Tao Ruoyu Huang Jingchen Yang Jiangfei Wang Kuanyu Wang |
| author_sort | Rui Tao |
| collection | DOAJ |
| description | Abstract Background As a component of membrane lipids and the precursor of oxysterols and steroid hormones, reprogrammed cholesterol metabolism contributes to the initiation and progression of multiple cancers. Thus, we aim to further investigate the significances of cholesterol metabolism in lower-grade gliomas (LGGs). Methods The present study included 413 LGG samples from TCGA RNA-seq dataset (training cohort) and 172 LGG samples from CGGA RNA-seq dataset (validation cohort). The cholesterol metabolism-related signature was identified by the LASSO regression model. Bioinformatics analyses were performed to explore the functional roles of this signature in LGGs. Kaplan-Meier and Cox regression analyses were enrolled to estimate prognostic value of the risk signature. Results Our findings suggested that cholesterol metabolism was tightly associated clinicopathologic features and genomic alterations of LGGs. Bioinformatics analyses revealed that cholesterol metabolism played a key role in immunosuppression of LGGs, mainly by promoting macrophages polarization and T cell exhaustion. Kaplan-Meier curve and Cox regression analysis showed that cholesterol metabolism was an independent prognostic indicator for LGG patients. To improve the clinical application value of the risk signature, we also constructed a nomogram model to predict the 1-, 3- and 5-year survival of LGG patients. Conclusion The cholesterol metabolism was powerful prognostic indicator and could serve as a promising target to enhance personalized treatment of LGGs. |
| first_indexed | 2024-03-12T21:09:00Z |
| format | Article |
| id | doaj.art-68fb54f9aed94109abf28c34e085b4a1 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-12T21:09:00Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-68fb54f9aed94109abf28c34e085b4a12023-07-30T11:17:52ZengBMCBMC Cancer1471-24072023-07-0123111810.1186/s12885-023-10897-0Comprehensive analysis of the clinical and biological significances of cholesterol metabolism in lower-grade gliomasRui Tao0Ruoyu Huang1Jingchen Yang2Jiangfei Wang3Kuanyu Wang4Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of stereotactic radiosurgery, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Background As a component of membrane lipids and the precursor of oxysterols and steroid hormones, reprogrammed cholesterol metabolism contributes to the initiation and progression of multiple cancers. Thus, we aim to further investigate the significances of cholesterol metabolism in lower-grade gliomas (LGGs). Methods The present study included 413 LGG samples from TCGA RNA-seq dataset (training cohort) and 172 LGG samples from CGGA RNA-seq dataset (validation cohort). The cholesterol metabolism-related signature was identified by the LASSO regression model. Bioinformatics analyses were performed to explore the functional roles of this signature in LGGs. Kaplan-Meier and Cox regression analyses were enrolled to estimate prognostic value of the risk signature. Results Our findings suggested that cholesterol metabolism was tightly associated clinicopathologic features and genomic alterations of LGGs. Bioinformatics analyses revealed that cholesterol metabolism played a key role in immunosuppression of LGGs, mainly by promoting macrophages polarization and T cell exhaustion. Kaplan-Meier curve and Cox regression analysis showed that cholesterol metabolism was an independent prognostic indicator for LGG patients. To improve the clinical application value of the risk signature, we also constructed a nomogram model to predict the 1-, 3- and 5-year survival of LGG patients. Conclusion The cholesterol metabolism was powerful prognostic indicator and could serve as a promising target to enhance personalized treatment of LGGs.https://doi.org/10.1186/s12885-023-10897-0Lower-grade gliomasRisk signatureTumor immune microenvironmentCholesterol metabolismPrognosis |
| spellingShingle | Rui Tao Ruoyu Huang Jingchen Yang Jiangfei Wang Kuanyu Wang Comprehensive analysis of the clinical and biological significances of cholesterol metabolism in lower-grade gliomas BMC Cancer Lower-grade gliomas Risk signature Tumor immune microenvironment Cholesterol metabolism Prognosis |
| title | Comprehensive analysis of the clinical and biological significances of cholesterol metabolism in lower-grade gliomas |
| title_full | Comprehensive analysis of the clinical and biological significances of cholesterol metabolism in lower-grade gliomas |
| title_fullStr | Comprehensive analysis of the clinical and biological significances of cholesterol metabolism in lower-grade gliomas |
| title_full_unstemmed | Comprehensive analysis of the clinical and biological significances of cholesterol metabolism in lower-grade gliomas |
| title_short | Comprehensive analysis of the clinical and biological significances of cholesterol metabolism in lower-grade gliomas |
| title_sort | comprehensive analysis of the clinical and biological significances of cholesterol metabolism in lower grade gliomas |
| topic | Lower-grade gliomas Risk signature Tumor immune microenvironment Cholesterol metabolism Prognosis |
| url | https://doi.org/10.1186/s12885-023-10897-0 |
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