Altered Maternal Serum Dynamic Thiol-Disulfide Interchange Reactions in Pregnant Women with Gestational Diabetes Mellitus
OBJECTIVE: We aimed to evaluate the alteration of dynamic thiol/disulfide homeostasis which basically shows the oxidative stress in body in pregnant women with gestational diabetes mellitus (GDM) by using a newly developed and automated analysis method. STUDY DESIGN: Study population consisted of b...
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| Format: | Article |
| Language: | English |
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Medical Network
2016-12-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
| Subjects: | |
| Online Access: | http://gorm.com.tr/index.php/GORM/article/view/71 |
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| author | Melahat Yıldırım Esengül Türkyılmaz Büşra Demir Cendek Gülcan Dauletkazin Murat Alışık Pervin Baran Ayşegül Cinkaya Ayşe Filiz Avşar Yavuz |
| author_facet | Melahat Yıldırım Esengül Türkyılmaz Büşra Demir Cendek Gülcan Dauletkazin Murat Alışık Pervin Baran Ayşegül Cinkaya Ayşe Filiz Avşar Yavuz |
| author_sort | Melahat Yıldırım |
| collection | DOAJ |
| description | OBJECTIVE: We aimed to evaluate the alteration of dynamic thiol/disulfide homeostasis which basically shows the oxidative stress in body in pregnant women with gestational diabetes mellitus (GDM) by using a newly developed and automated analysis method.
STUDY DESIGN: Study population consisted of body mass index and gestational age-matched pregnant women. Patients were subdivided into 3 groups based on their response to glucose challenge test (GCT) and oral glucose tolerance test (OGTT) results: (1) control group (normal GCT test results n= 87); (2) Impaired glucose tolerance (IGT) group ( n= 37); (3) GDM group (n=25). Maternal serum thiol and disulphide levels were compared among three groups.
RESULTS: Maternal serum thiol values were found decreased and maternal serum disulphide levels were increased in GDM groups were compared to control and IGT groups (Thiols for controls: 398.19±30.49 µmol/L, for IGT group 395.92±35.52 µmol/L, and for GDM group 371.89±41.14 µmol/L p= 0.002). Disulphides for controls; 17.47±4.38 µmol/L, for IGT; 19.27±3.34 µmol/L, for GDM group; 25.46±4.21 µmol/L, (p=0.001). Disulphide/thiol ratio was found to be increased in GDM group comparing to other groups (Disulphide/thiol ratio: 0.044±0.012 for controls, 0.049±0.009 for IGT group, 0.068±0.0103 for GDM group p=0.001)
CONCLUSION: Thiol- disulphide balance has shifted to the oxidative side in pregnant women with GDM. So blood glucose regulation is extremely crucial for reducing the oxidative stress which may lead to damages to vital organs of a mother or possibly to development of a fetus in women with GDM. |
| first_indexed | 2024-04-10T11:26:34Z |
| format | Article |
| id | doaj.art-68fb7968564243b98282c85c2eebefcf |
| institution | Directory Open Access Journal |
| issn | 1300-4751 |
| language | English |
| last_indexed | 2024-04-10T11:26:34Z |
| publishDate | 2016-12-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj.art-68fb7968564243b98282c85c2eebefcf2023-02-15T16:18:22ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512016-12-0122312913410.21613/GORM.2016.71432Altered Maternal Serum Dynamic Thiol-Disulfide Interchange Reactions in Pregnant Women with Gestational Diabetes MellitusMelahat Yıldırım0Esengül Türkyılmaz1Büşra Demir Cendek2Gülcan Dauletkazin3Murat Alışık4Pervin Baran5Ayşegül Cinkaya6Ayşe Filiz Avşar Yavuz7Yıldırım Beyazıt University Department of Obstetrics and Gynecology Bilkent, AnkaraAtatürk Training and Research Hospital Department of Obstetrics and Gynecology, Bilkent, AnkaraEtlik Zübeyde Hanım Women's Health and Education Hospital Department of Obstetrics and Gynecology, AnkaraAtatürk Training and Research Hospital Department of Obstetrics and Gynecology, Bilkent, AnkaraAtaturk Training and Research Hospital Department of Biochemistry Bilkent, AnkaraAtaturk Training and Research Hospital Department of Biochemistry Bilkent, AnkaraAtatürk Training and Research Hospital Department of Obstetrics and Gynecology, Bilkent, AnkaraYıldırım Beyazit University Department of Obstetrics and Gynecology Bilkent, AnkaraOBJECTIVE: We aimed to evaluate the alteration of dynamic thiol/disulfide homeostasis which basically shows the oxidative stress in body in pregnant women with gestational diabetes mellitus (GDM) by using a newly developed and automated analysis method. STUDY DESIGN: Study population consisted of body mass index and gestational age-matched pregnant women. Patients were subdivided into 3 groups based on their response to glucose challenge test (GCT) and oral glucose tolerance test (OGTT) results: (1) control group (normal GCT test results n= 87); (2) Impaired glucose tolerance (IGT) group ( n= 37); (3) GDM group (n=25). Maternal serum thiol and disulphide levels were compared among three groups. RESULTS: Maternal serum thiol values were found decreased and maternal serum disulphide levels were increased in GDM groups were compared to control and IGT groups (Thiols for controls: 398.19±30.49 µmol/L, for IGT group 395.92±35.52 µmol/L, and for GDM group 371.89±41.14 µmol/L p= 0.002). Disulphides for controls; 17.47±4.38 µmol/L, for IGT; 19.27±3.34 µmol/L, for GDM group; 25.46±4.21 µmol/L, (p=0.001). Disulphide/thiol ratio was found to be increased in GDM group comparing to other groups (Disulphide/thiol ratio: 0.044±0.012 for controls, 0.049±0.009 for IGT group, 0.068±0.0103 for GDM group p=0.001) CONCLUSION: Thiol- disulphide balance has shifted to the oxidative side in pregnant women with GDM. So blood glucose regulation is extremely crucial for reducing the oxidative stress which may lead to damages to vital organs of a mother or possibly to development of a fetus in women with GDM.http://gorm.com.tr/index.php/GORM/article/view/71Gestational diabetes mellitus, Oxidative stress, Thiol/disulphide exchange, Antioxidants |
| spellingShingle | Melahat Yıldırım Esengül Türkyılmaz Büşra Demir Cendek Gülcan Dauletkazin Murat Alışık Pervin Baran Ayşegül Cinkaya Ayşe Filiz Avşar Yavuz Altered Maternal Serum Dynamic Thiol-Disulfide Interchange Reactions in Pregnant Women with Gestational Diabetes Mellitus Gynecology Obstetrics & Reproductive Medicine Gestational diabetes mellitus, Oxidative stress, Thiol/disulphide exchange, Antioxidants |
| title | Altered Maternal Serum Dynamic Thiol-Disulfide Interchange Reactions in Pregnant Women with Gestational Diabetes Mellitus |
| title_full | Altered Maternal Serum Dynamic Thiol-Disulfide Interchange Reactions in Pregnant Women with Gestational Diabetes Mellitus |
| title_fullStr | Altered Maternal Serum Dynamic Thiol-Disulfide Interchange Reactions in Pregnant Women with Gestational Diabetes Mellitus |
| title_full_unstemmed | Altered Maternal Serum Dynamic Thiol-Disulfide Interchange Reactions in Pregnant Women with Gestational Diabetes Mellitus |
| title_short | Altered Maternal Serum Dynamic Thiol-Disulfide Interchange Reactions in Pregnant Women with Gestational Diabetes Mellitus |
| title_sort | altered maternal serum dynamic thiol disulfide interchange reactions in pregnant women with gestational diabetes mellitus |
| topic | Gestational diabetes mellitus, Oxidative stress, Thiol/disulphide exchange, Antioxidants |
| url | http://gorm.com.tr/index.php/GORM/article/view/71 |
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