The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses
Interactions between several tumor necrosis factor (TNF)-TNF receptor (TNFR) superfamily members that are expressed by T cells and NK cells and various other cell typesmodulate immune responses. This review summarizes the current understanding of how the TNF ligand-TNFR interactions 4-1BBL with 4-1B...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00402/full |
| _version_ | 1828780263422820352 |
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| author | Isabel eBarao |
| author_facet | Isabel eBarao |
| author_sort | Isabel eBarao |
| collection | DOAJ |
| description | Interactions between several tumor necrosis factor (TNF)-TNF receptor (TNFR) superfamily members that are expressed by T cells and NK cells and various other cell typesmodulate immune responses. This review summarizes the current understanding of how the TNF ligand-TNFR interactions 4-1BBL with 4-1BB, and GITRL with GITR regulate NK cell mediated antitumor responses and discuss its therapeutic implications. |
| first_indexed | 2024-12-11T17:15:22Z |
| format | Article |
| id | doaj.art-68fceea1520648a7b906ce594f3316c3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T17:15:22Z |
| publishDate | 2013-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-68fceea1520648a7b906ce594f3316c32022-12-22T00:57:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-01-01310.3389/fimmu.2012.0040237577The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responsesIsabel eBarao0University of Nevada, RenoInteractions between several tumor necrosis factor (TNF)-TNF receptor (TNFR) superfamily members that are expressed by T cells and NK cells and various other cell typesmodulate immune responses. This review summarizes the current understanding of how the TNF ligand-TNFR interactions 4-1BBL with 4-1BB, and GITRL with GITR regulate NK cell mediated antitumor responses and discuss its therapeutic implications.http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00402/fullLeukemiatherapyNK4-1BBGITR |
| spellingShingle | Isabel eBarao The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses Frontiers in Immunology Leukemia therapy NK 4-1BB GITR |
| title | The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses |
| title_full | The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses |
| title_fullStr | The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses |
| title_full_unstemmed | The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses |
| title_short | The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses |
| title_sort | tnf receptor ligands 4 1bb 4 1bbl and gitr gitrl in nk cell responses |
| topic | Leukemia therapy NK 4-1BB GITR |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00402/full |
| work_keys_str_mv | AT isabelebarao thetnfreceptorligands41bb41bblandgitrgitrlinnkcellresponses AT isabelebarao tnfreceptorligands41bb41bblandgitrgitrlinnkcellresponses |