Efp/TRIM25 and Its Related Protein, TRIM47, in Hormone-Dependent Cancers
Increasing attention has been paid to the biological roles of tripartite motif-containing (TRIM) family proteins, which typically function as E3 ubiquitin ligases. Estrogen-responsive finger protein (Efp), a member of the TRIM family proteins, also known as TRIM25, was originally identified as a pro...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/15/2464 |
| _version_ | 1827602981614256128 |
|---|---|
| author | Kotaro Azuma Satoshi Inoue |
| author_facet | Kotaro Azuma Satoshi Inoue |
| author_sort | Kotaro Azuma |
| collection | DOAJ |
| description | Increasing attention has been paid to the biological roles of tripartite motif-containing (TRIM) family proteins, which typically function as E3 ubiquitin ligases. Estrogen-responsive finger protein (Efp), a member of the TRIM family proteins, also known as TRIM25, was originally identified as a protein induced by estrogen and plays critical roles in promoting endocrine-related cancers, including breast cancer, endometrial cancer, and prostate cancer. The pathophysiological importance of Efp made us interested in the roles of other TRIM family proteins that share a similar structure with Efp. Based on a phylogenetic analysis of the C-terminal region of TRIM family proteins, we focused on TRIM47 as a protein belonging to the same branch as Efp. TRIM47 is a poor prognostic factor in both breast cancer and prostate cancer. Atypical lysine-27-like poly-ubiquitination was involved in the underlying mechanism causing endocrine resistance in breast cancer. We also discuss the functions of Efp and TRIM47 in other types of cancers and innate immunity by introducing substrates the are modified by poly-ubiquitination. |
| first_indexed | 2024-03-09T05:30:15Z |
| format | Article |
| id | doaj.art-68fe194170aa4764a9ba79dc71e36c40 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T05:30:15Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-68fe194170aa4764a9ba79dc71e36c402023-12-03T12:32:56ZengMDPI AGCells2073-44092022-08-011115246410.3390/cells11152464Efp/TRIM25 and Its Related Protein, TRIM47, in Hormone-Dependent CancersKotaro Azuma0Satoshi Inoue1Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, JapanDepartment of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, JapanIncreasing attention has been paid to the biological roles of tripartite motif-containing (TRIM) family proteins, which typically function as E3 ubiquitin ligases. Estrogen-responsive finger protein (Efp), a member of the TRIM family proteins, also known as TRIM25, was originally identified as a protein induced by estrogen and plays critical roles in promoting endocrine-related cancers, including breast cancer, endometrial cancer, and prostate cancer. The pathophysiological importance of Efp made us interested in the roles of other TRIM family proteins that share a similar structure with Efp. Based on a phylogenetic analysis of the C-terminal region of TRIM family proteins, we focused on TRIM47 as a protein belonging to the same branch as Efp. TRIM47 is a poor prognostic factor in both breast cancer and prostate cancer. Atypical lysine-27-like poly-ubiquitination was involved in the underlying mechanism causing endocrine resistance in breast cancer. We also discuss the functions of Efp and TRIM47 in other types of cancers and innate immunity by introducing substrates the are modified by poly-ubiquitination.https://www.mdpi.com/2073-4409/11/15/2464estrogen-responsive finger protein (Efp)TRIM family proteinsTRIM25TRIM47hormone-dependent cancersbreast cancer |
| spellingShingle | Kotaro Azuma Satoshi Inoue Efp/TRIM25 and Its Related Protein, TRIM47, in Hormone-Dependent Cancers Cells estrogen-responsive finger protein (Efp) TRIM family proteins TRIM25 TRIM47 hormone-dependent cancers breast cancer |
| title | Efp/TRIM25 and Its Related Protein, TRIM47, in Hormone-Dependent Cancers |
| title_full | Efp/TRIM25 and Its Related Protein, TRIM47, in Hormone-Dependent Cancers |
| title_fullStr | Efp/TRIM25 and Its Related Protein, TRIM47, in Hormone-Dependent Cancers |
| title_full_unstemmed | Efp/TRIM25 and Its Related Protein, TRIM47, in Hormone-Dependent Cancers |
| title_short | Efp/TRIM25 and Its Related Protein, TRIM47, in Hormone-Dependent Cancers |
| title_sort | efp trim25 and its related protein trim47 in hormone dependent cancers |
| topic | estrogen-responsive finger protein (Efp) TRIM family proteins TRIM25 TRIM47 hormone-dependent cancers breast cancer |
| url | https://www.mdpi.com/2073-4409/11/15/2464 |
| work_keys_str_mv | AT kotaroazuma efptrim25anditsrelatedproteintrim47inhormonedependentcancers AT satoshiinoue efptrim25anditsrelatedproteintrim47inhormonedependentcancers |