Leptin in Dental Pulp and Periapical Tissues: A Narrative Review
Leptin is a non-glycosylated 16 kDa protein synthesized mainly in adipose cells. The main function of leptin is to regulate energy homeostasis and weight control in a central manner. There is increasing evidence that leptin also has systemic effects, acting as a link between innate and acquired immu...
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/4/1984 |
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| author | Jenifer Martin-Gonzalez Juan J. Segura-Egea Antonio Pérez-Pérez Daniel Cabanillas-Balsera Víctor Sánchez-Margalet |
| author_facet | Jenifer Martin-Gonzalez Juan J. Segura-Egea Antonio Pérez-Pérez Daniel Cabanillas-Balsera Víctor Sánchez-Margalet |
| author_sort | Jenifer Martin-Gonzalez |
| collection | DOAJ |
| description | Leptin is a non-glycosylated 16 kDa protein synthesized mainly in adipose cells. The main function of leptin is to regulate energy homeostasis and weight control in a central manner. There is increasing evidence that leptin also has systemic effects, acting as a link between innate and acquired immune responses. The expression of leptin and its receptor in human dental pulp and periradicular tissues have already been described, as well as several stimulatory effects of leptin protein expression in dental and periodontal tissues. The aim of this paper was to review and to compile the reported scientific literature on the role and effects of leptin in the dental pulp and periapical tissues. Twelve articles accomplished the inclusion criteria, and a comprehensive narrative review was carried out. Review of the available scientific literature concluded that leptin has the following effects on pulpal and periapical physiology: 1) Stimulates odontogenic differentiation of dental pulp stem cells (DPSCs), 2) Increases the expression of dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1), odontoblastic proteins involved in odontoblastic differentiation and dentin mineralization, 3) Stimulates vascular endothelial growth factor (VEGF) expression in human dental pulp tissue and primary cultured cells of human dental pulp (hDPCs), 4) Stimulates angiogenesis in rat dental pulp cells, and 5) Induces the expression of interleucinas 6 and 8 in human periodontal ligament cells (hPDLCs). There is evidence which suggests that leptin is implicated in the dentin mineralization process and in pulpal and periapical inflammatory and reparative responses. |
| first_indexed | 2024-03-09T21:45:58Z |
| format | Article |
| id | doaj.art-68ffaab8ba9e4e6a9dc84b291388e181 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:45:58Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-68ffaab8ba9e4e6a9dc84b291388e1812023-11-23T20:17:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-02-01234198410.3390/ijms23041984Leptin in Dental Pulp and Periapical Tissues: A Narrative ReviewJenifer Martin-Gonzalez0Juan J. Segura-Egea1Antonio Pérez-Pérez2Daniel Cabanillas-Balsera3Víctor Sánchez-Margalet4Endodontic Section, Department of Stomatology, University of Sevilla, C/Avicena s/n, 41009 Sevilla, SpainEndodontic Section, Department of Stomatology, University of Sevilla, C/Avicena s/n, 41009 Sevilla, SpainDepartment of Clinical Biochemistry, Virgen Macarena University Hospital, University of Sevilla, 41009 Sevilla, SpainEndodontic Section, Department of Stomatology, University of Sevilla, C/Avicena s/n, 41009 Sevilla, SpainDepartment of Clinical Biochemistry, Virgen Macarena University Hospital, University of Sevilla, 41009 Sevilla, SpainLeptin is a non-glycosylated 16 kDa protein synthesized mainly in adipose cells. The main function of leptin is to regulate energy homeostasis and weight control in a central manner. There is increasing evidence that leptin also has systemic effects, acting as a link between innate and acquired immune responses. The expression of leptin and its receptor in human dental pulp and periradicular tissues have already been described, as well as several stimulatory effects of leptin protein expression in dental and periodontal tissues. The aim of this paper was to review and to compile the reported scientific literature on the role and effects of leptin in the dental pulp and periapical tissues. Twelve articles accomplished the inclusion criteria, and a comprehensive narrative review was carried out. Review of the available scientific literature concluded that leptin has the following effects on pulpal and periapical physiology: 1) Stimulates odontogenic differentiation of dental pulp stem cells (DPSCs), 2) Increases the expression of dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1), odontoblastic proteins involved in odontoblastic differentiation and dentin mineralization, 3) Stimulates vascular endothelial growth factor (VEGF) expression in human dental pulp tissue and primary cultured cells of human dental pulp (hDPCs), 4) Stimulates angiogenesis in rat dental pulp cells, and 5) Induces the expression of interleucinas 6 and 8 in human periodontal ligament cells (hPDLCs). There is evidence which suggests that leptin is implicated in the dentin mineralization process and in pulpal and periapical inflammatory and reparative responses.https://www.mdpi.com/1422-0067/23/4/1984leptinleptin receptordental pulpperiapical tissuesDMP-1DSPP |
| spellingShingle | Jenifer Martin-Gonzalez Juan J. Segura-Egea Antonio Pérez-Pérez Daniel Cabanillas-Balsera Víctor Sánchez-Margalet Leptin in Dental Pulp and Periapical Tissues: A Narrative Review International Journal of Molecular Sciences leptin leptin receptor dental pulp periapical tissues DMP-1 DSPP |
| title | Leptin in Dental Pulp and Periapical Tissues: A Narrative Review |
| title_full | Leptin in Dental Pulp and Periapical Tissues: A Narrative Review |
| title_fullStr | Leptin in Dental Pulp and Periapical Tissues: A Narrative Review |
| title_full_unstemmed | Leptin in Dental Pulp and Periapical Tissues: A Narrative Review |
| title_short | Leptin in Dental Pulp and Periapical Tissues: A Narrative Review |
| title_sort | leptin in dental pulp and periapical tissues a narrative review |
| topic | leptin leptin receptor dental pulp periapical tissues DMP-1 DSPP |
| url | https://www.mdpi.com/1422-0067/23/4/1984 |
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