Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver Disease
Pathological fibrosis of the liver is a landmark feature in chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Diagnosis and assessment of progress or treatment efficacy today requires biopsy of the liver, which is a challenge in, e.g....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/14/7348 |
| _version_ | 1797527035553251328 |
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| author | Olivia Wegrzyniak Maria Rosestedt Olof Eriksson |
| author_facet | Olivia Wegrzyniak Maria Rosestedt Olof Eriksson |
| author_sort | Olivia Wegrzyniak |
| collection | DOAJ |
| description | Pathological fibrosis of the liver is a landmark feature in chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Diagnosis and assessment of progress or treatment efficacy today requires biopsy of the liver, which is a challenge in, e.g., longitudinal interventional studies. Molecular imaging techniques such as positron emission tomography (PET) have the potential to enable minimally invasive assessment of liver fibrosis. This review will summarize and discuss the current status of the development of innovative imaging markers for processes relevant for fibrogenesis in liver, e.g., certain immune cells, activated fibroblasts, and collagen depositions. |
| first_indexed | 2024-03-10T09:37:16Z |
| format | Article |
| id | doaj.art-6904e61ece694afb90a43339162e55cb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:37:16Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6904e61ece694afb90a43339162e55cb2023-11-22T03:57:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-012214734810.3390/ijms22147348Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver DiseaseOlivia Wegrzyniak0Maria Rosestedt1Olof Eriksson2Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, SE-751 83 Uppsala, SwedenScience for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, SE-751 83 Uppsala, SwedenScience for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, SE-751 83 Uppsala, SwedenPathological fibrosis of the liver is a landmark feature in chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Diagnosis and assessment of progress or treatment efficacy today requires biopsy of the liver, which is a challenge in, e.g., longitudinal interventional studies. Molecular imaging techniques such as positron emission tomography (PET) have the potential to enable minimally invasive assessment of liver fibrosis. This review will summarize and discuss the current status of the development of innovative imaging markers for processes relevant for fibrogenesis in liver, e.g., certain immune cells, activated fibroblasts, and collagen depositions.https://www.mdpi.com/1422-0067/22/14/7348positron emission tomographyimagingimmune cellsfibroblastscollagenfibrosis |
| spellingShingle | Olivia Wegrzyniak Maria Rosestedt Olof Eriksson Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver Disease International Journal of Molecular Sciences positron emission tomography imaging immune cells fibroblasts collagen fibrosis |
| title | Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver Disease |
| title_full | Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver Disease |
| title_fullStr | Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver Disease |
| title_full_unstemmed | Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver Disease |
| title_short | Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver Disease |
| title_sort | recent progress in the molecular imaging of nonalcoholic fatty liver disease |
| topic | positron emission tomography imaging immune cells fibroblasts collagen fibrosis |
| url | https://www.mdpi.com/1422-0067/22/14/7348 |
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