Multidrug-Resistant Organisms and Their Association with Risk Factors; A Study at the Intensive Care Unit of Tertiary Care Hospital, Peshawar
Objective: To investigate rates of multidrug-resistant organisms (MDRO) infection, their antimicrobial resistance (AMR) patterns, and risk factors for acquisition of such infections at a Tertiary-Care Hospital ICU. Study Design: Cross sectional study. Place and Duration of Study: Adult Intensi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2023-12-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://www.pafmj.org/PAFMJ/article/view/10323 |
| _version_ | 1797341013962915840 |
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| author | Mariam Sarwar Fuad Ahmad Siddiqi Salman Riaz Ammad Hasan Chaudhry Muhammad Hassan Ashfaq Hussain |
| author_facet | Mariam Sarwar Fuad Ahmad Siddiqi Salman Riaz Ammad Hasan Chaudhry Muhammad Hassan Ashfaq Hussain |
| author_sort | Mariam Sarwar |
| collection | DOAJ |
| description |
Objective: To investigate rates of multidrug-resistant organisms (MDRO) infection, their antimicrobial resistance (AMR)
patterns, and risk factors for acquisition of such infections at a Tertiary-Care Hospital ICU.
Study Design: Cross sectional study.
Place and Duration of Study: Adult Intensive Care Unit of Tertiary Care Hospital, Peshawar Pakistan, from Jan to Dec 2022.
Methodology: All patients admitted to adult ICU who developed signs/symptoms of infection after 48 hours of admission
were investigated. Microbiological diagnosis was done via standard microbiological practices, and if the patient had acquired an MDRO infection, it was included in the study.
Results: During the study, 92 patients acquired MDRO infection in total. The most common source was blood (43.5%). The
most common organisms isolated were Klebsiella pneumoniae (21.7%), Acinetobacter baumannii (20.7%) and Pseudomonas
aeruginosa (17.4%). The highest percentage of resistance among Gram-positive organisms was exhibited to Penicillin and
Co-amoxiclav (91%). Gram-negative isolates exhibited high overall resistance to all used antibiotic classes. The least frequency of resistance was recorded for Tigecycline (1%) against Klebsiella pneumoniae and 33% against Escherichia coli, while 32% Acinetobacter baumannii and 25% Pseudomonas aeruginosa were Colistin/Polymyxin resistant; none of the Klebsiella pneumoniae showed Colistin resistance.
Conclusion: Antimicrobial resistance in our setup was high among Gram-negative and Gram-positive organisms. The most
common risk factor was central line placement among the patients, highlighting the importance of infection control measures and the need to implement infection control bundles to circumvent infections due to invasive devices.
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| first_indexed | 2024-03-08T10:11:45Z |
| format | Article |
| id | doaj.art-6907ca328c57460e9d9db1cd552d1cd1 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-03-08T10:11:45Z |
| publishDate | 2023-12-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-6907ca328c57460e9d9db1cd552d1cd12024-01-29T08:22:23ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422023-12-0173610.51253/pafmj.v73i6.10323Multidrug-Resistant Organisms and Their Association with Risk Factors; A Study at the Intensive Care Unit of Tertiary Care Hospital, PeshawarMariam Sarwar0Fuad Ahmad Siddiqi1Salman Riaz2Ammad Hasan Chaudhry3Muhammad Hassan4Ashfaq Hussain5Combined Military Hospital/National University of Medical Sciences (NUMS) Peshawar PakistanCombined Military Hospital/National University of Medical Sciences (NUMS) Peshawar PakistanRHQ Hospital, Gilgit PakistanCombined Military Hospital/National University of Medical Sciences (NUMS) Peshawar PakistanBanazir Bhutto Hospital, Rawalpindi PakistanCombined Military Hospital/National University of Medical Sciences (NUMS) Mardan Pakistan Objective: To investigate rates of multidrug-resistant organisms (MDRO) infection, their antimicrobial resistance (AMR) patterns, and risk factors for acquisition of such infections at a Tertiary-Care Hospital ICU. Study Design: Cross sectional study. Place and Duration of Study: Adult Intensive Care Unit of Tertiary Care Hospital, Peshawar Pakistan, from Jan to Dec 2022. Methodology: All patients admitted to adult ICU who developed signs/symptoms of infection after 48 hours of admission were investigated. Microbiological diagnosis was done via standard microbiological practices, and if the patient had acquired an MDRO infection, it was included in the study. Results: During the study, 92 patients acquired MDRO infection in total. The most common source was blood (43.5%). The most common organisms isolated were Klebsiella pneumoniae (21.7%), Acinetobacter baumannii (20.7%) and Pseudomonas aeruginosa (17.4%). The highest percentage of resistance among Gram-positive organisms was exhibited to Penicillin and Co-amoxiclav (91%). Gram-negative isolates exhibited high overall resistance to all used antibiotic classes. The least frequency of resistance was recorded for Tigecycline (1%) against Klebsiella pneumoniae and 33% against Escherichia coli, while 32% Acinetobacter baumannii and 25% Pseudomonas aeruginosa were Colistin/Polymyxin resistant; none of the Klebsiella pneumoniae showed Colistin resistance. Conclusion: Antimicrobial resistance in our setup was high among Gram-negative and Gram-positive organisms. The most common risk factor was central line placement among the patients, highlighting the importance of infection control measures and the need to implement infection control bundles to circumvent infections due to invasive devices. https://www.pafmj.org/PAFMJ/article/view/10323Multidrug-resistant organisms (MDRO)Antimicrobial resistance (AMR)Intensive care unit |
| spellingShingle | Mariam Sarwar Fuad Ahmad Siddiqi Salman Riaz Ammad Hasan Chaudhry Muhammad Hassan Ashfaq Hussain Multidrug-Resistant Organisms and Their Association with Risk Factors; A Study at the Intensive Care Unit of Tertiary Care Hospital, Peshawar Pakistan Armed Forces Medical Journal Multidrug-resistant organisms (MDRO) Antimicrobial resistance (AMR) Intensive care unit |
| title | Multidrug-Resistant Organisms and Their Association with Risk Factors; A Study at the Intensive Care Unit of Tertiary Care Hospital, Peshawar |
| title_full | Multidrug-Resistant Organisms and Their Association with Risk Factors; A Study at the Intensive Care Unit of Tertiary Care Hospital, Peshawar |
| title_fullStr | Multidrug-Resistant Organisms and Their Association with Risk Factors; A Study at the Intensive Care Unit of Tertiary Care Hospital, Peshawar |
| title_full_unstemmed | Multidrug-Resistant Organisms and Their Association with Risk Factors; A Study at the Intensive Care Unit of Tertiary Care Hospital, Peshawar |
| title_short | Multidrug-Resistant Organisms and Their Association with Risk Factors; A Study at the Intensive Care Unit of Tertiary Care Hospital, Peshawar |
| title_sort | multidrug resistant organisms and their association with risk factors a study at the intensive care unit of tertiary care hospital peshawar |
| topic | Multidrug-resistant organisms (MDRO) Antimicrobial resistance (AMR) Intensive care unit |
| url | https://www.pafmj.org/PAFMJ/article/view/10323 |
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