Enriching Medication Review with a Pharmacogenetic Profile – A Case of Tamoxifen Adverse Drug Reactions
Chiara Jeiziner,1 Céline K Stäuble,1,2 Markus L Lampert,1 Kurt E Hersberger,1 Henriette E Meyer zu Schwabedissen2 1Pharmaceutical Care Research Group, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland; 2Biopharmacy, Department of Pharmaceutical Scienc...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-02-01
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| Series: | Pharmacogenomics and Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/enriching-medication-review-with-a-pharmacogenetic-profile-ndash-a-cas-peer-reviewed-article-PGPM |
| _version_ | 1818406760734523392 |
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| author | Jeiziner C Stäuble CK Lampert ML Hersberger KE Meyer zu Schwabedissen HE |
| author_facet | Jeiziner C Stäuble CK Lampert ML Hersberger KE Meyer zu Schwabedissen HE |
| author_sort | Jeiziner C |
| collection | DOAJ |
| description | Chiara Jeiziner,1 Céline K Stäuble,1,2 Markus L Lampert,1 Kurt E Hersberger,1 Henriette E Meyer zu Schwabedissen2 1Pharmaceutical Care Research Group, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland; 2Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, SwitzerlandCorrespondence: Chiara JeizinerPharmaceutical Care Research Group; University of Basel, Petersplatz 14, Postfach 2148, Basel, 4001, SwitzerlandTel +41 61 207 61 80Email chiara.jeiziner@unibas.chAbstract: Pharmacogenotyping is applied to determine the hereditable component of a patient’s susceptibility to experience therapy failure and/or adverse drug reactions (ADRs). We present the case of a female patient diagnosed with breast cancer and treated with tamoxifen as recurrence therapy who experienced various ADRs. Pharmacogenotyping revealed variants in the cytochrome P450 (CYP) enzymes CYP2D6, CYP2C9, and CYP2C19. The observed genotype was associated with a risk for lower tamoxifen efficacy. Aside from the tamoxifen therapy, the comedication was reviewed for the influence of the patient’s pharmacogenetic profile. As a result of this pharmacist-led medication review with pharmacogenetic analyses, concrete genotype-driven recommendations for the treating gynecologist were compiled. This case revealed the added value of a large pharmacogenetic panel and the complexity of integrating a pharmacogenetic profile into a recommendation.Keywords: pharmacogenetics, PGx, CYP2D6, CYP2C9, CYP2C19, medication review, tamoxifen |
| first_indexed | 2024-12-14T09:17:04Z |
| format | Article |
| id | doaj.art-6909e732d4c64f7cb08c6d46b40472cc |
| institution | Directory Open Access Journal |
| issn | 1178-7066 |
| language | English |
| last_indexed | 2024-12-14T09:17:04Z |
| publishDate | 2021-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Pharmacogenomics and Personalized Medicine |
| spelling | doaj.art-6909e732d4c64f7cb08c6d46b40472cc2022-12-21T23:08:24ZengDove Medical PressPharmacogenomics and Personalized Medicine1178-70662021-02-01Volume 1427928662319Enriching Medication Review with a Pharmacogenetic Profile – A Case of Tamoxifen Adverse Drug ReactionsJeiziner CStäuble CKLampert MLHersberger KEMeyer zu Schwabedissen HEChiara Jeiziner,1 Céline K Stäuble,1,2 Markus L Lampert,1 Kurt E Hersberger,1 Henriette E Meyer zu Schwabedissen2 1Pharmaceutical Care Research Group, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland; 2Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, SwitzerlandCorrespondence: Chiara JeizinerPharmaceutical Care Research Group; University of Basel, Petersplatz 14, Postfach 2148, Basel, 4001, SwitzerlandTel +41 61 207 61 80Email chiara.jeiziner@unibas.chAbstract: Pharmacogenotyping is applied to determine the hereditable component of a patient’s susceptibility to experience therapy failure and/or adverse drug reactions (ADRs). We present the case of a female patient diagnosed with breast cancer and treated with tamoxifen as recurrence therapy who experienced various ADRs. Pharmacogenotyping revealed variants in the cytochrome P450 (CYP) enzymes CYP2D6, CYP2C9, and CYP2C19. The observed genotype was associated with a risk for lower tamoxifen efficacy. Aside from the tamoxifen therapy, the comedication was reviewed for the influence of the patient’s pharmacogenetic profile. As a result of this pharmacist-led medication review with pharmacogenetic analyses, concrete genotype-driven recommendations for the treating gynecologist were compiled. This case revealed the added value of a large pharmacogenetic panel and the complexity of integrating a pharmacogenetic profile into a recommendation.Keywords: pharmacogenetics, PGx, CYP2D6, CYP2C9, CYP2C19, medication review, tamoxifenhttps://www.dovepress.com/enriching-medication-review-with-a-pharmacogenetic-profile-ndash-a-cas-peer-reviewed-article-PGPMpharmacogenetics (pgx)cyp2d6cyp2c9cyp2c19medication reviewtamoxifen |
| spellingShingle | Jeiziner C Stäuble CK Lampert ML Hersberger KE Meyer zu Schwabedissen HE Enriching Medication Review with a Pharmacogenetic Profile – A Case of Tamoxifen Adverse Drug Reactions Pharmacogenomics and Personalized Medicine pharmacogenetics (pgx) cyp2d6 cyp2c9 cyp2c19 medication review tamoxifen |
| title | Enriching Medication Review with a Pharmacogenetic Profile – A Case of Tamoxifen Adverse Drug Reactions |
| title_full | Enriching Medication Review with a Pharmacogenetic Profile – A Case of Tamoxifen Adverse Drug Reactions |
| title_fullStr | Enriching Medication Review with a Pharmacogenetic Profile – A Case of Tamoxifen Adverse Drug Reactions |
| title_full_unstemmed | Enriching Medication Review with a Pharmacogenetic Profile – A Case of Tamoxifen Adverse Drug Reactions |
| title_short | Enriching Medication Review with a Pharmacogenetic Profile – A Case of Tamoxifen Adverse Drug Reactions |
| title_sort | enriching medication review with a pharmacogenetic profile ndash a case of tamoxifen adverse drug reactions |
| topic | pharmacogenetics (pgx) cyp2d6 cyp2c9 cyp2c19 medication review tamoxifen |
| url | https://www.dovepress.com/enriching-medication-review-with-a-pharmacogenetic-profile-ndash-a-cas-peer-reviewed-article-PGPM |
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