Guar gum and similar soluble fibers in the regulation of cholesterol metabolism: Current understandings and future research priorities
Todd C Rideout1, Scott V Harding1, Peter JH Jones1, Ming Z Fan21Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada; 2Centre for Nutrition Modeling, Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, CanadaAbstra...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2008-10-01
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| Series: | Vascular Health and Risk Management |
| Subjects: | |
| Online Access: | https://www.dovepress.com/guar-gum-and-similar-soluble-fibers-in-the-regulation-of-cholesterol-m-peer-reviewed-article-VHRM |
| _version_ | 1818232834988441600 |
|---|---|
| author | Todd C Rideout Scott V Harding Peter JH Jones Ming Z Fan |
| author_facet | Todd C Rideout Scott V Harding Peter JH Jones Ming Z Fan |
| author_sort | Todd C Rideout |
| collection | DOAJ |
| description | Todd C Rideout1, Scott V Harding1, Peter JH Jones1, Ming Z Fan21Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada; 2Centre for Nutrition Modeling, Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, CanadaAbstract: The hypocholesterolemic effects associated with soluble fiber consumption are clear from animal model and human clinical investigations. Moreover, the modulation of whole-body cholesterol metabolism in response to dietary fiber consumption, including intestinal cholesterol absorption and fecal sterol and bile acid loss, has been the subject of many published reports. However, our understanding of how dietary fibers regulate molecular events at the gene/protein level and alter cellular cholesterol metabolism is limited. The modern emphasis on molecular nutrition and rapid progress in ‘high-dimensional’ biological techniques will permit further explorations of the role of genetic polymorphisms in determining the variable interindividual responses to soluble fibers. Furthermore, with traditional molecular biology tools and the application of ‘omic’ technology, specific insight into how fibers modulate the expression of genes and proteins that regulate intestinal cholesterol absorption and alter hepatic sterol balance will be gained. Detailed knowledge of the molecular mechanisms by which soluble fibers reduce plasma cholesterol concentrations is paramount to developing novel fiber-based “cocktails” that target specific metabolic pathways to gain maximal cholesterol reductions.Keywords: dietary fiber, cholesterol, bile acids, gene, protein |
| first_indexed | 2024-12-12T11:12:35Z |
| format | Article |
| id | doaj.art-690cfbfc4e4c4c188b230d7d2793479e |
| institution | Directory Open Access Journal |
| issn | 1178-2048 |
| language | English |
| last_indexed | 2024-12-12T11:12:35Z |
| publishDate | 2008-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-690cfbfc4e4c4c188b230d7d2793479e2022-12-22T00:26:14ZengDove Medical PressVascular Health and Risk Management1178-20482008-10-01Volume 4102310332007Guar gum and similar soluble fibers in the regulation of cholesterol metabolism: Current understandings and future research prioritiesTodd C RideoutScott V HardingPeter JH JonesMing Z FanTodd C Rideout1, Scott V Harding1, Peter JH Jones1, Ming Z Fan21Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada; 2Centre for Nutrition Modeling, Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, CanadaAbstract: The hypocholesterolemic effects associated with soluble fiber consumption are clear from animal model and human clinical investigations. Moreover, the modulation of whole-body cholesterol metabolism in response to dietary fiber consumption, including intestinal cholesterol absorption and fecal sterol and bile acid loss, has been the subject of many published reports. However, our understanding of how dietary fibers regulate molecular events at the gene/protein level and alter cellular cholesterol metabolism is limited. The modern emphasis on molecular nutrition and rapid progress in ‘high-dimensional’ biological techniques will permit further explorations of the role of genetic polymorphisms in determining the variable interindividual responses to soluble fibers. Furthermore, with traditional molecular biology tools and the application of ‘omic’ technology, specific insight into how fibers modulate the expression of genes and proteins that regulate intestinal cholesterol absorption and alter hepatic sterol balance will be gained. Detailed knowledge of the molecular mechanisms by which soluble fibers reduce plasma cholesterol concentrations is paramount to developing novel fiber-based “cocktails” that target specific metabolic pathways to gain maximal cholesterol reductions.Keywords: dietary fiber, cholesterol, bile acids, gene, proteinhttps://www.dovepress.com/guar-gum-and-similar-soluble-fibers-in-the-regulation-of-cholesterol-m-peer-reviewed-article-VHRMdietary fibercholesterolbile acidsgeneprotein |
| spellingShingle | Todd C Rideout Scott V Harding Peter JH Jones Ming Z Fan Guar gum and similar soluble fibers in the regulation of cholesterol metabolism: Current understandings and future research priorities Vascular Health and Risk Management dietary fiber cholesterol bile acids gene protein |
| title | Guar gum and similar soluble fibers in the regulation of cholesterol metabolism: Current understandings and future research priorities |
| title_full | Guar gum and similar soluble fibers in the regulation of cholesterol metabolism: Current understandings and future research priorities |
| title_fullStr | Guar gum and similar soluble fibers in the regulation of cholesterol metabolism: Current understandings and future research priorities |
| title_full_unstemmed | Guar gum and similar soluble fibers in the regulation of cholesterol metabolism: Current understandings and future research priorities |
| title_short | Guar gum and similar soluble fibers in the regulation of cholesterol metabolism: Current understandings and future research priorities |
| title_sort | guar gum and similar soluble fibers in the regulation of cholesterol metabolism current understandings and future research priorities |
| topic | dietary fiber cholesterol bile acids gene protein |
| url | https://www.dovepress.com/guar-gum-and-similar-soluble-fibers-in-the-regulation-of-cholesterol-m-peer-reviewed-article-VHRM |
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