Left Perforated Colonic Tumor with Synchronous Locally Advanced Right Colonic Tumor
Colorectal cancer is one of the most common malignant neoplasms worldwide. Overall mortality is 33%. Synchronous colorectal cancer refers to more than one malignant tumor detected in different segments of the colon, simultaneously or within 6 months of initial diagnosis. The development of colorecta...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2022-12-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/527954 |
| _version_ | 1797960814022361088 |
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| author | Marco Antonio Robles González Marcela Pérez Villaseñor Ana Alfaro Cruz Sergio Ulises Pérez Escobedo Yanetzy Elizabet Corona Flores |
| author_facet | Marco Antonio Robles González Marcela Pérez Villaseñor Ana Alfaro Cruz Sergio Ulises Pérez Escobedo Yanetzy Elizabet Corona Flores |
| author_sort | Marco Antonio Robles González |
| collection | DOAJ |
| description | Colorectal cancer is one of the most common malignant neoplasms worldwide. Overall mortality is 33%. Synchronous colorectal cancer refers to more than one malignant tumor detected in different segments of the colon, simultaneously or within 6 months of initial diagnosis. The development of colorectal cancer is a multistep process that originates with a genetic mutation leading to a malignant phenotype and generating a growth advantage. Colorectal cancer presents up to 16% of hypermutations, of which 75% are characterized by microsatellite instability which in turn leads to poorer cell differentiation. Patients with synchronous tumors appear to have a higher proportion of microsatellite instability than patients with single tumors. The clinical case of a 35-year-old man with a perforated left colon tumor and a locally advanced synchronous tumor of the right colon and signs of acute abdomen is presented. The treatment should be based on the location of the synchronous tumors, stage at the time of approach, and the patient’s condition. However, when faced with a complication secondary to colonic cancer, adhering to the principles of oncological surgery can be overcome by the nature of the emergency. |
| first_indexed | 2024-04-11T00:50:06Z |
| format | Article |
| id | doaj.art-690de43552ef4a35b9b1af51ee606955 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-04-11T00:50:06Z |
| publishDate | 2022-12-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-690de43552ef4a35b9b1af51ee6069552023-01-05T09:14:12ZengKarger PublishersCase Reports in Gastroenterology1662-06312022-12-0116365266210.1159/000527954527954Left Perforated Colonic Tumor with Synchronous Locally Advanced Right Colonic TumorMarco Antonio Robles González0Marcela Pérez Villaseñor1Ana Alfaro Cruz2Sergio Ulises Pérez Escobedo3Yanetzy Elizabet Corona Flores4https://orcid.org/0000-0001-6231-3465Clínica de Patología Quirúrgica Aguda, Servicio de Cirugía General, Hospital General de México, “Dr. Eduardo Liceaga,”, Mexico City, MexicoPatología Quirúrgica, Servicio de Anatomía Patológica, Hospital General de México, “Dr. Eduardo Liceaga,”, Mexico City, MexicoPatología Quirúrgica, Servicio de Anatomía Patológica, Hospital General de México, “Dr. Eduardo Liceaga,”, Mexico City, MexicoClínica de Patología Quirúrgica Aguda, Servicio de Cirugía General, Hospital General de México, “Dr. Eduardo Liceaga,”, Mexico City, MexicoServicio de Urgencias Médicas, Hospital de Especialidades “Belisario Domínguez,”, Mexico City, MexicoColorectal cancer is one of the most common malignant neoplasms worldwide. Overall mortality is 33%. Synchronous colorectal cancer refers to more than one malignant tumor detected in different segments of the colon, simultaneously or within 6 months of initial diagnosis. The development of colorectal cancer is a multistep process that originates with a genetic mutation leading to a malignant phenotype and generating a growth advantage. Colorectal cancer presents up to 16% of hypermutations, of which 75% are characterized by microsatellite instability which in turn leads to poorer cell differentiation. Patients with synchronous tumors appear to have a higher proportion of microsatellite instability than patients with single tumors. The clinical case of a 35-year-old man with a perforated left colon tumor and a locally advanced synchronous tumor of the right colon and signs of acute abdomen is presented. The treatment should be based on the location of the synchronous tumors, stage at the time of approach, and the patient’s condition. However, when faced with a complication secondary to colonic cancer, adhering to the principles of oncological surgery can be overcome by the nature of the emergency.https://www.karger.com/Article/FullText/527954colorectal cancersynchronous tumorperforated cancermicrosatellite instability |
| spellingShingle | Marco Antonio Robles González Marcela Pérez Villaseñor Ana Alfaro Cruz Sergio Ulises Pérez Escobedo Yanetzy Elizabet Corona Flores Left Perforated Colonic Tumor with Synchronous Locally Advanced Right Colonic Tumor Case Reports in Gastroenterology colorectal cancer synchronous tumor perforated cancer microsatellite instability |
| title | Left Perforated Colonic Tumor with Synchronous Locally Advanced Right Colonic Tumor |
| title_full | Left Perforated Colonic Tumor with Synchronous Locally Advanced Right Colonic Tumor |
| title_fullStr | Left Perforated Colonic Tumor with Synchronous Locally Advanced Right Colonic Tumor |
| title_full_unstemmed | Left Perforated Colonic Tumor with Synchronous Locally Advanced Right Colonic Tumor |
| title_short | Left Perforated Colonic Tumor with Synchronous Locally Advanced Right Colonic Tumor |
| title_sort | left perforated colonic tumor with synchronous locally advanced right colonic tumor |
| topic | colorectal cancer synchronous tumor perforated cancer microsatellite instability |
| url | https://www.karger.com/Article/FullText/527954 |
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