Screening antiproliferative drug for breast cancer from bisbenzylisoquinoline alkaloid tetrandrine and fangchinoline derivatives by targeting BLM helicase

Screening antiproliferative drug for breast cancer from bisbenzylisoquinoline alkaloid tetrandrine and fangchinoline derivatives by targeting BLM helicase

Abstract Background The high expression of BLM (Bloom syndrome) helicase in tumors involves its strong association with cell expansion. Bisbenzylisoquinoline alkaloids own an antitumor property and have developed as candidates for anticancer drugs. This paper aimed to screen potential antiproliferat...

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Bibliographic Details
Main Authors: Wangming Zhang, Shuang Yang, Jinhe Liu, Linchun Bao, He Lu, Hong Li, Weidong Pan, Yanchao Jiao, Zhixu He, Jielin Liu
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Cancer
Subjects:
BLM helicase
HJNO
Fluorescence polarization
EMSA
MTT
RT-PCR
Online Access:http://link.springer.com/article/10.1186/s12885-019-6146-7

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http://link.springer.com/article/10.1186/s12885-019-6146-7

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