Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes
The addition of amide/sulfonamide bonds to alkynes is not only one of the most important strategies for the direct functionalization of carbon–carbon triple bonds, but also a powerful tool for the downstream transformations of amides/sulfonamides. The present review provides a comprehensiv...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-01-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/24/1/164 |
| _version_ | 1818128234749886464 |
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| author | Fei Zhao Pinyi Li Xiaoyan Liu Xiuwen Jia Jiang Wang Hong Liu |
| author_facet | Fei Zhao Pinyi Li Xiaoyan Liu Xiuwen Jia Jiang Wang Hong Liu |
| author_sort | Fei Zhao |
| collection | DOAJ |
| description | The addition of amide/sulfonamide bonds to alkynes is not only one of the most important strategies for the direct functionalization of carbon–carbon triple bonds, but also a powerful tool for the downstream transformations of amides/sulfonamides. The present review provides a comprehensive summary of amide/sulfonamide bond addition to alkynes, including direct and metal-free aminoacylation, based-promoted aminoacylation, transition-metal-catalyzed aminoacylation, organocatalytic aminoacylation and transition-metal-catalyzed aminosulfonylation of alkynes up to December 2018. The reaction conditions, regio- and stereoselectivities, and mechanisms are discussed and summarized in detail. |
| first_indexed | 2024-12-11T07:30:01Z |
| format | Article |
| id | doaj.art-690f5a702ada436cbc3b0f89c1520a1b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T07:30:01Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-690f5a702ada436cbc3b0f89c1520a1b2022-12-22T01:15:51ZengMDPI AGMolecules1420-30492019-01-0124116410.3390/molecules24010164molecules24010164Recent Advances in the Addition of Amide/Sulfonamide Bonds to AlkynesFei Zhao0Pinyi Li1Xiaoyan Liu2Xiuwen Jia3Jiang Wang4Hong Liu5Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, 168 Hua Guan Road, Chengdu 610052, ChinaAntibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, 168 Hua Guan Road, Chengdu 610052, ChinaAntibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, 168 Hua Guan Road, Chengdu 610052, ChinaAntibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, 168 Hua Guan Road, Chengdu 610052, ChinaState Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, ChinaState Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, ChinaThe addition of amide/sulfonamide bonds to alkynes is not only one of the most important strategies for the direct functionalization of carbon–carbon triple bonds, but also a powerful tool for the downstream transformations of amides/sulfonamides. The present review provides a comprehensive summary of amide/sulfonamide bond addition to alkynes, including direct and metal-free aminoacylation, based-promoted aminoacylation, transition-metal-catalyzed aminoacylation, organocatalytic aminoacylation and transition-metal-catalyzed aminosulfonylation of alkynes up to December 2018. The reaction conditions, regio- and stereoselectivities, and mechanisms are discussed and summarized in detail.http://www.mdpi.com/1420-3049/24/1/164amide bondsulfonamide bondalkynesaddition reactionaminoacylationaminosulfonylation |
| spellingShingle | Fei Zhao Pinyi Li Xiaoyan Liu Xiuwen Jia Jiang Wang Hong Liu Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes Molecules amide bond sulfonamide bond alkynes addition reaction aminoacylation aminosulfonylation |
| title | Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes |
| title_full | Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes |
| title_fullStr | Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes |
| title_full_unstemmed | Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes |
| title_short | Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes |
| title_sort | recent advances in the addition of amide sulfonamide bonds to alkynes |
| topic | amide bond sulfonamide bond alkynes addition reaction aminoacylation aminosulfonylation |
| url | http://www.mdpi.com/1420-3049/24/1/164 |
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