Association of adenosine signaling gene signature with estrogen receptor-positive breast and prostate cancer bone metastasis

Association of adenosine signaling gene signature with estrogen receptor-positive breast and prostate cancer bone metastasis

Bone metastasis is a common and devastating consequence of several major cancer types, including breast and prostate. Osteocytes are the predominant bone cell, and through connexin (Cx) 43 hemichannels release ATP to the bone microenvironment that can be hydrolyzed to adenosine. Here, we investigate...

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Bibliographic Details
Main Authors: Daniel Brian Shropshire, Francisca M. Acosta, Kun Fang, Jaime Benavides, Lu-Zhe Sun, Victor X. Jin, Jean X. Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Medicine
Subjects:
metastasis
bone
breast
prostate
purinergic
osteocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.965429/full

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