Clinical Practice Guideline for Solid Organ Donation and Transplantation During the COVID-19 Pandemic
Background. The coronavirus 2019 (COVID-19) pandemic has disrupted health systems worldwide, including solid organ donation and transplantation programs. Guidance on how best to screen patients who are potential organ donors to minimize the risks of COVID-19 as well as how best to manage immunosuppr...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2021-10-01
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| Series: | Transplantation Direct |
| Online Access: | http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001199 |
| _version_ | 1818438902609870848 |
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| author | Matthew J. Weiss, MD Laura Hornby, MSc Farid Foroutan, PhD Sara Belga, MD Simon Bernier Mamatha Bhat, MD C. Arianne Buchan, MD Michael Gagnon, MD Gillian Hardman, MBBS, FRCSed(C-Th) Maria Ibrahim, MD Cindy Luo, PharmD Me-Linh Luong, MD Rahul Mainra, MD, FRCPC Alex R. Manara, MD Ruth Sapir-Pichhadze, MD Sarah Shalhoub, MD Tina Shaver, RN, BN Jeffrey M. Singh, MD Sujitha Srinathan Ian Thomas, MD Lindsay C. Wilson, MHA T. Murray Wilson, MBA Alissa Wright, MD Allison Mah, MD |
| author_facet | Matthew J. Weiss, MD Laura Hornby, MSc Farid Foroutan, PhD Sara Belga, MD Simon Bernier Mamatha Bhat, MD C. Arianne Buchan, MD Michael Gagnon, MD Gillian Hardman, MBBS, FRCSed(C-Th) Maria Ibrahim, MD Cindy Luo, PharmD Me-Linh Luong, MD Rahul Mainra, MD, FRCPC Alex R. Manara, MD Ruth Sapir-Pichhadze, MD Sarah Shalhoub, MD Tina Shaver, RN, BN Jeffrey M. Singh, MD Sujitha Srinathan Ian Thomas, MD Lindsay C. Wilson, MHA T. Murray Wilson, MBA Alissa Wright, MD Allison Mah, MD |
| author_sort | Matthew J. Weiss, MD |
| collection | DOAJ |
| description | Background. The coronavirus 2019 (COVID-19) pandemic has disrupted health systems worldwide, including solid organ donation and transplantation programs. Guidance on how best to screen patients who are potential organ donors to minimize the risks of COVID-19 as well as how best to manage immunosuppression and reduce the risk of COVID-19 and manage infection in solid organ transplant recipients (SOTr) is needed.
Methods. Iterative literature searches were conducted, the last being January 2021, by a team of 3 information specialists. Stakeholders representing key groups undertook the systematic reviews and generation of recommendations using a rapid response approach that respected the Appraisal of Guidelines for Research and Evaluation II and Grading of Recommendations, Assessment, Development and Evaluations frameworks.
Results. The systematic reviews addressed multiple questions of interest. In this guidance document, we make 4 strong recommendations, 7 weak recommendations, 3 good practice statements, and 3 statements of “no recommendation.”
Conclusions. SOTr and patients on the waitlist are populations of interest in the COVID-19 pandemic. Currently, there is a paucity of high-quality evidence to guide decisions around deceased donation assessments and the management of SOTr and waitlist patients. Inclusion of these populations in clinical trials of therapeutic interventions, including vaccine candidates, is essential to guide best practices. |
| first_indexed | 2024-12-14T17:47:57Z |
| format | Article |
| id | doaj.art-6911d92142284bbab759fc0ac1d92dbe |
| institution | Directory Open Access Journal |
| issn | 2373-8731 |
| language | English |
| last_indexed | 2024-12-14T17:47:57Z |
| publishDate | 2021-10-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Transplantation Direct |
| spelling | doaj.art-6911d92142284bbab759fc0ac1d92dbe2022-12-21T22:52:42ZengWolters KluwerTransplantation Direct2373-87312021-10-01710e75510.1097/TXD.0000000000001199202110000-00010Clinical Practice Guideline for Solid Organ Donation and Transplantation During the COVID-19 PandemicMatthew J. Weiss, MD0Laura Hornby, MSc1Farid Foroutan, PhD2Sara Belga, MD3Simon Bernier4Mamatha Bhat, MD5C. Arianne Buchan, MD6Michael Gagnon, MD7Gillian Hardman, MBBS, FRCSed(C-Th)8Maria Ibrahim, MD9Cindy Luo, PharmD10Me-Linh Luong, MD11Rahul Mainra, MD, FRCPC12Alex R. Manara, MD13Ruth Sapir-Pichhadze, MD14Sarah Shalhoub, MD15Tina Shaver, RN, BN16Jeffrey M. Singh, MD17Sujitha Srinathan18Ian Thomas, MD19Lindsay C. Wilson, MHA20T. Murray Wilson, MBA21Alissa Wright, MD22Allison Mah, MD231 Transplant Québec, Montréal, QC, Canada.3 Canadian Donation and Transplantation Research Program (CDTRP), Ottawa, ON, Canada5 Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.7 Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.8 Faculty of Medicine, Université Laval, QC, Canada.9 Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, ON, Canada.11 Division of Infectious Diseases, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.12 Division of Nephrology and Multi-Organ Transplant Program, Department of Medicine, McGill University, Montreal, QC, Canada.13 National Health Service Blood and Transplant, Bristol, United Kingdom.13 National Health Service Blood and Transplant, Bristol, United Kingdom.15 Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.16 Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montréal, QC, Canada.17 Division of Nephrology, University of Saskatchewan, Saskatoon, SK, Canada.13 National Health Service Blood and Transplant, Bristol, United Kingdom.12 Division of Nephrology and Multi-Organ Transplant Program, Department of Medicine, McGill University, Montreal, QC, Canada.21 Division of Infectious Diseases, Department of Medicine, Western University, London, ON, Canada.22 Southern Alberta Organ and Tissue Donation Program, Calgary, AB, Canada.23 Department of Medicine, University of Toronto, Toronto, Ontario, ON, Canada.9 Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, ON, Canada.13 National Health Service Blood and Transplant, Bristol, United Kingdom.4 System Development – Organ and Tissue Donation and Transplantation, Canadian Blood Services, Ottawa, ON, Canada.25 Transplant Research Foundation of British Columbia, Vancouver, BC, Canada.28 Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.28 Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.Background. The coronavirus 2019 (COVID-19) pandemic has disrupted health systems worldwide, including solid organ donation and transplantation programs. Guidance on how best to screen patients who are potential organ donors to minimize the risks of COVID-19 as well as how best to manage immunosuppression and reduce the risk of COVID-19 and manage infection in solid organ transplant recipients (SOTr) is needed. Methods. Iterative literature searches were conducted, the last being January 2021, by a team of 3 information specialists. Stakeholders representing key groups undertook the systematic reviews and generation of recommendations using a rapid response approach that respected the Appraisal of Guidelines for Research and Evaluation II and Grading of Recommendations, Assessment, Development and Evaluations frameworks. Results. The systematic reviews addressed multiple questions of interest. In this guidance document, we make 4 strong recommendations, 7 weak recommendations, 3 good practice statements, and 3 statements of “no recommendation.” Conclusions. SOTr and patients on the waitlist are populations of interest in the COVID-19 pandemic. Currently, there is a paucity of high-quality evidence to guide decisions around deceased donation assessments and the management of SOTr and waitlist patients. Inclusion of these populations in clinical trials of therapeutic interventions, including vaccine candidates, is essential to guide best practices.http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001199 |
| spellingShingle | Matthew J. Weiss, MD Laura Hornby, MSc Farid Foroutan, PhD Sara Belga, MD Simon Bernier Mamatha Bhat, MD C. Arianne Buchan, MD Michael Gagnon, MD Gillian Hardman, MBBS, FRCSed(C-Th) Maria Ibrahim, MD Cindy Luo, PharmD Me-Linh Luong, MD Rahul Mainra, MD, FRCPC Alex R. Manara, MD Ruth Sapir-Pichhadze, MD Sarah Shalhoub, MD Tina Shaver, RN, BN Jeffrey M. Singh, MD Sujitha Srinathan Ian Thomas, MD Lindsay C. Wilson, MHA T. Murray Wilson, MBA Alissa Wright, MD Allison Mah, MD Clinical Practice Guideline for Solid Organ Donation and Transplantation During the COVID-19 Pandemic Transplantation Direct |
| title | Clinical Practice Guideline for Solid Organ Donation and Transplantation During the COVID-19 Pandemic |
| title_full | Clinical Practice Guideline for Solid Organ Donation and Transplantation During the COVID-19 Pandemic |
| title_fullStr | Clinical Practice Guideline for Solid Organ Donation and Transplantation During the COVID-19 Pandemic |
| title_full_unstemmed | Clinical Practice Guideline for Solid Organ Donation and Transplantation During the COVID-19 Pandemic |
| title_short | Clinical Practice Guideline for Solid Organ Donation and Transplantation During the COVID-19 Pandemic |
| title_sort | clinical practice guideline for solid organ donation and transplantation during the covid 19 pandemic |
| url | http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001199 |
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