A new method for studying the mechanism of “Feature Identification based quality assessment” of Traditional Chinese Medicine, taking Gastrodiae Rhizoma as an example
Aim of the study: The research group proposed that the mechanism of “Feature Identification based Quality Assessment” (FIQA) of Traditional Chinese Medicine (TCM) can be explained according to the relationship between the “Feature” of TCM and the Pharmacodynamic Components representing the holistic...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022016425 |
| _version_ | 1818472589065977856 |
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| author | Wang Bing Sun Yan-tao Pei Wen-han Zhang Hui Kang Ting-guo |
| author_facet | Wang Bing Sun Yan-tao Pei Wen-han Zhang Hui Kang Ting-guo |
| author_sort | Wang Bing |
| collection | DOAJ |
| description | Aim of the study: The research group proposed that the mechanism of “Feature Identification based Quality Assessment” (FIQA) of Traditional Chinese Medicine (TCM) can be explained according to the relationship between the “Feature” of TCM and the Pharmacodynamic Components representing the holistic effect of TCM. Gastrodiae Rhizoma (GR) was selected as the research object to reveal the close relationship between “Feature” and the quality of TCM. Materials and methods: In this study, the “Feature” such as “Shape”, “Color”, “Odour” and “Taste” of GR are quantified by the electronic nose, electronic tongue, and other instruments. Then, the Pharmacodynamic Components Group (PCG) of GR was determined which could reflect the holistic effect of GR by spectrum effect relationship analysis. By analyzing the correlation between the “Feature” and the content of PCG, the mechanism of FIQA of GR was determined. Results: The quantitative results of “Shape”, “Color”, “Odour” and “Taste” of GR from different sources were significantly different. Six components were selected as the PCG, which can represent the holistic effect of GR in the aspect of the neuroprotective effect. There was a good correlation between the components in the PCG and “Feature”. Conclusions: The quality of GR can be determined quantitatively according to its “Shape”, “Color”, “Odour” and “Taste”. The mechanism of FIQA of TCM can be explained according to the relationship between the Shape of TCM and the Pharmacodynamic Components representing the quality of TCM. The revelation of this mechanism reflects the holistic characteristics of the multi-component synergistic effect of TCM. This study provides a reference research method for revealing the mechanism of FIQA of TCM. |
| first_indexed | 2024-04-14T04:09:32Z |
| format | Article |
| id | doaj.art-691361474a8e4f22bf0c2c5e177fa491 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-14T04:09:32Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-691361474a8e4f22bf0c2c5e177fa4912022-12-22T02:13:15ZengElsevierHeliyon2405-84402022-08-0188e10354A new method for studying the mechanism of “Feature Identification based quality assessment” of Traditional Chinese Medicine, taking Gastrodiae Rhizoma as an exampleWang Bing0Sun Yan-tao1Pei Wen-han2Zhang Hui3Kang Ting-guo4College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, 116600, ChinaCollege of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, 116600, ChinaMacau University of Science and Technology, Macau, 999078, ChinaCollege of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, 116600, China; Corresponding author.College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, 116600, China; Corresponding author.Aim of the study: The research group proposed that the mechanism of “Feature Identification based Quality Assessment” (FIQA) of Traditional Chinese Medicine (TCM) can be explained according to the relationship between the “Feature” of TCM and the Pharmacodynamic Components representing the holistic effect of TCM. Gastrodiae Rhizoma (GR) was selected as the research object to reveal the close relationship between “Feature” and the quality of TCM. Materials and methods: In this study, the “Feature” such as “Shape”, “Color”, “Odour” and “Taste” of GR are quantified by the electronic nose, electronic tongue, and other instruments. Then, the Pharmacodynamic Components Group (PCG) of GR was determined which could reflect the holistic effect of GR by spectrum effect relationship analysis. By analyzing the correlation between the “Feature” and the content of PCG, the mechanism of FIQA of GR was determined. Results: The quantitative results of “Shape”, “Color”, “Odour” and “Taste” of GR from different sources were significantly different. Six components were selected as the PCG, which can represent the holistic effect of GR in the aspect of the neuroprotective effect. There was a good correlation between the components in the PCG and “Feature”. Conclusions: The quality of GR can be determined quantitatively according to its “Shape”, “Color”, “Odour” and “Taste”. The mechanism of FIQA of TCM can be explained according to the relationship between the Shape of TCM and the Pharmacodynamic Components representing the quality of TCM. The revelation of this mechanism reflects the holistic characteristics of the multi-component synergistic effect of TCM. This study provides a reference research method for revealing the mechanism of FIQA of TCM.http://www.sciencedirect.com/science/article/pii/S2405844022016425Feature identification based quality assessmentFeaturePharmacodynamic components groupQualityRelevance |
| spellingShingle | Wang Bing Sun Yan-tao Pei Wen-han Zhang Hui Kang Ting-guo A new method for studying the mechanism of “Feature Identification based quality assessment” of Traditional Chinese Medicine, taking Gastrodiae Rhizoma as an example Heliyon Feature identification based quality assessment Feature Pharmacodynamic components group Quality Relevance |
| title | A new method for studying the mechanism of “Feature Identification based quality assessment” of Traditional Chinese Medicine, taking Gastrodiae Rhizoma as an example |
| title_full | A new method for studying the mechanism of “Feature Identification based quality assessment” of Traditional Chinese Medicine, taking Gastrodiae Rhizoma as an example |
| title_fullStr | A new method for studying the mechanism of “Feature Identification based quality assessment” of Traditional Chinese Medicine, taking Gastrodiae Rhizoma as an example |
| title_full_unstemmed | A new method for studying the mechanism of “Feature Identification based quality assessment” of Traditional Chinese Medicine, taking Gastrodiae Rhizoma as an example |
| title_short | A new method for studying the mechanism of “Feature Identification based quality assessment” of Traditional Chinese Medicine, taking Gastrodiae Rhizoma as an example |
| title_sort | new method for studying the mechanism of feature identification based quality assessment of traditional chinese medicine taking gastrodiae rhizoma as an example |
| topic | Feature identification based quality assessment Feature Pharmacodynamic components group Quality Relevance |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022016425 |
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