A narrative review of organoids for investigating organ aging: opportunities and challenges
Aging research has shifted from studying phenotypes to studying in-depth mechanisms in recent decades. However, extrapolating cellular and molecular bases of aging from studying traditional model systems to humans has been challenging. The advent of organoids holds promise for overcoming the limitat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health
2023-03-01
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| Series: | Journal of Bio-X Research |
| Online Access: | http://journals.lww.com/10.1097/JBR.0000000000000139 |
| _version_ | 1797817496882905088 |
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| author | Xiaoyan Sun Fei Sun Yixin Zhang Jing Qu Weiqi Zhang Guang-Hui Liu |
| author_facet | Xiaoyan Sun Fei Sun Yixin Zhang Jing Qu Weiqi Zhang Guang-Hui Liu |
| author_sort | Xiaoyan Sun |
| collection | DOAJ |
| description | Aging research has shifted from studying phenotypes to studying in-depth mechanisms in recent decades. However, extrapolating cellular and molecular bases of aging from studying traditional model systems to humans has been challenging. The advent of organoids holds promise for overcoming the limitations of monolayer cell culture and bridging the gap between animal models and humans. Here, we mainly discuss recent paradigms for using organoid models in studying organ aging. Pluripotent stem cells–derived organoid provides a promising platform for simulating the pathophysiology of several aging-related diseases, especially neurodegenerative diseases, and adult stem cells organoids derived from different age groups have been applied to detect aging-related functional changes. We also assess the value of organoid model systems in understanding human aging and aging-related diseases, and identify challenges to be addressed in the future, such as the immaturity of organoids, and effective methods of inducing aging. |
| first_indexed | 2024-03-13T08:54:20Z |
| format | Article |
| id | doaj.art-6916a209645a46678b3d6878ec54e3bb |
| institution | Directory Open Access Journal |
| issn | 2096-5672 |
| language | English |
| last_indexed | 2024-03-13T08:54:20Z |
| publishDate | 2023-03-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Journal of Bio-X Research |
| spelling | doaj.art-6916a209645a46678b3d6878ec54e3bb2023-05-29T03:41:20ZengWolters Kluwer HealthJournal of Bio-X Research2096-56722023-03-016131410.1097/JBR.0000000000000139202303000-00002A narrative review of organoids for investigating organ aging: opportunities and challengesXiaoyan Sun0Fei Sun1Yixin Zhang2Jing Qu3Weiqi Zhang4Guang-Hui Liu5a CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciencesc Department of Cell Biology, Duke University Medical Center, Durham, NC, USAd State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoologyd State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoologya CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciencese Institute for Stem Cell and Regeneration, Chinese Academy of SciencesAging research has shifted from studying phenotypes to studying in-depth mechanisms in recent decades. However, extrapolating cellular and molecular bases of aging from studying traditional model systems to humans has been challenging. The advent of organoids holds promise for overcoming the limitations of monolayer cell culture and bridging the gap between animal models and humans. Here, we mainly discuss recent paradigms for using organoid models in studying organ aging. Pluripotent stem cells–derived organoid provides a promising platform for simulating the pathophysiology of several aging-related diseases, especially neurodegenerative diseases, and adult stem cells organoids derived from different age groups have been applied to detect aging-related functional changes. We also assess the value of organoid model systems in understanding human aging and aging-related diseases, and identify challenges to be addressed in the future, such as the immaturity of organoids, and effective methods of inducing aging.http://journals.lww.com/10.1097/JBR.0000000000000139 |
| spellingShingle | Xiaoyan Sun Fei Sun Yixin Zhang Jing Qu Weiqi Zhang Guang-Hui Liu A narrative review of organoids for investigating organ aging: opportunities and challenges Journal of Bio-X Research |
| title | A narrative review of organoids for investigating organ aging: opportunities and challenges |
| title_full | A narrative review of organoids for investigating organ aging: opportunities and challenges |
| title_fullStr | A narrative review of organoids for investigating organ aging: opportunities and challenges |
| title_full_unstemmed | A narrative review of organoids for investigating organ aging: opportunities and challenges |
| title_short | A narrative review of organoids for investigating organ aging: opportunities and challenges |
| title_sort | narrative review of organoids for investigating organ aging opportunities and challenges |
| url | http://journals.lww.com/10.1097/JBR.0000000000000139 |
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