The hepatoprotective role of the aqueous extract of ginger against the harmful effects of paracetamol in rats
This study was performed to determine the hepatoprotectiveactivities of watery extract of ginger in hepatotoxicity induced by paracetamolin albino rats. Twenty fourrats were used and divided randomly into four equal groups each of which contain six animals, the first one was served as control, rec...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Thi-Qar
2019-05-01
|
| Series: | مجلة علوم ذي قار |
| Subjects: | |
| Online Access: | https://www.jsci.utq.edu.iq/index.php/main/article/view/137 |
| Summary: | This study was performed to determine the hepatoprotectiveactivities of watery extract of ginger in hepatotoxicity
induced by paracetamolin albino rats. Twenty fourrats were used and divided randomly into four equal groups each of
which contain six animals, the first one was served as control, received nomal saline only, the second group were
received paracetamol at a single dose of 3g/kg/B.W orally to induce hepatotoxicity, and the third and fourth groups
received watery extract of ginger at a dose 200 mg/Kg & 400 mg/Kg B.W orally once daily for 3 days respectively
followed by administration of single dose of paracetamol 3 g/Kg B.Wafter 30 minute after extracts administration. Liver
functions were assessed by estimating serumalanine amino transferase (ALT) , aspartate amino transferase (AST) ,
alkaline phosphatase (ALP), total serum bilirubin & total serum protein & albumin . The results revealed that the use of
genger extracts at each dose ( 200 mg/Kg , 400 mg/Kg B.W) produced significant reduction in the level of these
enzymes , total bilirubin while caused significant increase in the levels of total serum protein & total serum albumin ,
so the use of ginger extracts possess hepatoprotective activity by restoring the normal hepatic functions and potentiating
the bio- defense system of the liver against hepatotoxicity produced by paracetamol administration
|
|---|---|
| ISSN: | 1991-8690 2709-0256 |