Diagnostic accuracy of synovial fluid D-lactate for periprosthetic joint infection: a systematic review and meta-analysis
Abstract Background Periprosthetic joint infection is a grievous complication after arthroplasty that greatly affects the quality of life of patients. Rapid establishment of infection diagnosis is essential, but great challenges still exist. Methods We conducted research in the PubMed, Embase, and C...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-021-02778-8 |
| _version_ | 1811300381526851584 |
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| author | Zhizhuo Li Chengxin Li Guangxue Wang Lijun Shi Tengqi Li Xiaoyu Fan Xin Xu Peixu Wang Fuqiang Gao Wei Sun |
| author_facet | Zhizhuo Li Chengxin Li Guangxue Wang Lijun Shi Tengqi Li Xiaoyu Fan Xin Xu Peixu Wang Fuqiang Gao Wei Sun |
| author_sort | Zhizhuo Li |
| collection | DOAJ |
| description | Abstract Background Periprosthetic joint infection is a grievous complication after arthroplasty that greatly affects the quality of life of patients. Rapid establishment of infection diagnosis is essential, but great challenges still exist. Methods We conducted research in the PubMed, Embase, and Cochrane databases to evaluate the diagnostic accuracy of D-lactate for PJI. Data extraction and quality assessment were completed independently by two reviewers. The pooled sensitivity, specificity, likelihood ratios, diagnostic odds ratio (DOR), summarized receiver operating characteristic curve (sROC), and area under the sROC curve (AUC) were constructed using the bivariate meta-analysis framework. Results Five eligible studies were included in the quantitative analysis. The pooled sensitivity and specificity of D-lactate for the diagnosis of PJI were 0.82 (95% CI 0.70–0.89) and 0.76 (95% CI 0.69–0.82), respectively. The value of the pooled diagnostic odds ratio (DOR) of D-lactate for PJI was 14.18 (95% CI 6.17–32.58), and the area under the curve (AUC) was 0.84 (95% CI 0.80–0.87). Conclusions According to the results of our meta-analysis, D-lactate is a valuable synovial fluid marker for recognizing PJI, with high sensitivity and specificity. |
| first_indexed | 2024-04-13T06:50:27Z |
| format | Article |
| id | doaj.art-691b4a3d21524c9f98bad20826d322c9 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-13T06:50:27Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-691b4a3d21524c9f98bad20826d322c92022-12-22T02:57:25ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2021-10-0116111010.1186/s13018-021-02778-8Diagnostic accuracy of synovial fluid D-lactate for periprosthetic joint infection: a systematic review and meta-analysisZhizhuo Li0Chengxin Li1Guangxue Wang2Lijun Shi3Tengqi Li4Xiaoyu Fan5Xin Xu6Peixu Wang7Fuqiang Gao8Wei Sun9Department of Orthopedics, Peking University China-Japan Friendship School of Clinical MedicineDepartment of Orthopedics, Peking University China-Japan Friendship School of Clinical MedicineDepartment of Orthopedics, Peking University China-Japan Friendship School of Clinical MedicineDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Orthopedics, Peking University China-Japan Friendship School of Clinical MedicineDepartment of Orthopedics, Graduate School of Peking Union Medical College, China-Japan Friendship Institute of Clinical MedicineDepartment of Orthopedics, Graduate School of Peking Union Medical College, China-Japan Friendship Institute of Clinical MedicineBeijing Key Laboratory of Immune Inflammatory Disease, China-Japan Friendship Hospital, Peking Union Medical CollegeBeijing Key Laboratory of Immune Inflammatory Disease, China-Japan Friendship Hospital, Peking Union Medical CollegeAbstract Background Periprosthetic joint infection is a grievous complication after arthroplasty that greatly affects the quality of life of patients. Rapid establishment of infection diagnosis is essential, but great challenges still exist. Methods We conducted research in the PubMed, Embase, and Cochrane databases to evaluate the diagnostic accuracy of D-lactate for PJI. Data extraction and quality assessment were completed independently by two reviewers. The pooled sensitivity, specificity, likelihood ratios, diagnostic odds ratio (DOR), summarized receiver operating characteristic curve (sROC), and area under the sROC curve (AUC) were constructed using the bivariate meta-analysis framework. Results Five eligible studies were included in the quantitative analysis. The pooled sensitivity and specificity of D-lactate for the diagnosis of PJI were 0.82 (95% CI 0.70–0.89) and 0.76 (95% CI 0.69–0.82), respectively. The value of the pooled diagnostic odds ratio (DOR) of D-lactate for PJI was 14.18 (95% CI 6.17–32.58), and the area under the curve (AUC) was 0.84 (95% CI 0.80–0.87). Conclusions According to the results of our meta-analysis, D-lactate is a valuable synovial fluid marker for recognizing PJI, with high sensitivity and specificity.https://doi.org/10.1186/s13018-021-02778-8D-lactateSynovial fluidPeriprosthetic joint infectionArthroplastyMeta-analysis |
| spellingShingle | Zhizhuo Li Chengxin Li Guangxue Wang Lijun Shi Tengqi Li Xiaoyu Fan Xin Xu Peixu Wang Fuqiang Gao Wei Sun Diagnostic accuracy of synovial fluid D-lactate for periprosthetic joint infection: a systematic review and meta-analysis Journal of Orthopaedic Surgery and Research D-lactate Synovial fluid Periprosthetic joint infection Arthroplasty Meta-analysis |
| title | Diagnostic accuracy of synovial fluid D-lactate for periprosthetic joint infection: a systematic review and meta-analysis |
| title_full | Diagnostic accuracy of synovial fluid D-lactate for periprosthetic joint infection: a systematic review and meta-analysis |
| title_fullStr | Diagnostic accuracy of synovial fluid D-lactate for periprosthetic joint infection: a systematic review and meta-analysis |
| title_full_unstemmed | Diagnostic accuracy of synovial fluid D-lactate for periprosthetic joint infection: a systematic review and meta-analysis |
| title_short | Diagnostic accuracy of synovial fluid D-lactate for periprosthetic joint infection: a systematic review and meta-analysis |
| title_sort | diagnostic accuracy of synovial fluid d lactate for periprosthetic joint infection a systematic review and meta analysis |
| topic | D-lactate Synovial fluid Periprosthetic joint infection Arthroplasty Meta-analysis |
| url | https://doi.org/10.1186/s13018-021-02778-8 |
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