The Flavonoid Cyanidin Shows Immunomodulatory and Broad-Spectrum Antiviral Properties, Including SARS-CoV-2
New antiviral treatments are needed to deal with the unpredictable emergence of viruses. Furthermore, vaccines and antivirals are only available for just a few viral infections, and antiviral drug resistance is an increasing concern. Cyanidin (a natural product also called A18), a key flavonoid that...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/4/989 |
| _version_ | 1797603210773397504 |
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| author | Josefina Vicente Martina Benedetti Paula Martelliti Luciana Vázquez María Virginia Gentilini Freddy Armando Peñaranda Figueredo Mercedes Soledad Nabaes Jodar Mariana Viegas Andrea Alejandra Barquero Carlos Alberto Bueno |
| author_facet | Josefina Vicente Martina Benedetti Paula Martelliti Luciana Vázquez María Virginia Gentilini Freddy Armando Peñaranda Figueredo Mercedes Soledad Nabaes Jodar Mariana Viegas Andrea Alejandra Barquero Carlos Alberto Bueno |
| author_sort | Josefina Vicente |
| collection | DOAJ |
| description | New antiviral treatments are needed to deal with the unpredictable emergence of viruses. Furthermore, vaccines and antivirals are only available for just a few viral infections, and antiviral drug resistance is an increasing concern. Cyanidin (a natural product also called A18), a key flavonoid that is present in red berries and other fruits, attenuates the development of several diseases, through its anti-inflammatory effects. Regarding its mechanism of action, A18 was identified as an IL-17A inhibitor, resulting in the attenuation of IL-17A signaling and associated diseases in mice. Importantly, A18 also inhibits the NF-κB signaling pathway in different cell types and conditions in vitro and in vivo. In this study, we report that A18 restricts RSV, HSV-1, canine coronavirus, and SARS-CoV-2 multiplication, indicating a broad-spectrum antiviral activity. We also found that A18 can control cytokine and NF-κB induction in RSV-infected cells independently of its antiviral activity. Furthermore, in mice infected with RSV, A18 not only significantly reduces viral titers in the lungs, but also diminishes lung injury. Thus, these results provide evidence that A18 could be used as a broad-spectrum antiviral and may contribute to the development of novel therapeutic targets to control these viral infections and pathogenesis. |
| first_indexed | 2024-03-11T04:26:10Z |
| format | Article |
| id | doaj.art-691d2fb5918c4c04afc7edeee091d843 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T04:26:10Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-691d2fb5918c4c04afc7edeee091d8432023-11-17T21:46:37ZengMDPI AGViruses1999-49152023-04-0115498910.3390/v15040989The Flavonoid Cyanidin Shows Immunomodulatory and Broad-Spectrum Antiviral Properties, Including SARS-CoV-2Josefina Vicente0Martina Benedetti1Paula Martelliti2Luciana Vázquez3María Virginia Gentilini4Freddy Armando Peñaranda Figueredo5Mercedes Soledad Nabaes Jodar6Mariana Viegas7Andrea Alejandra Barquero8Carlos Alberto Bueno9Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires 1428, ArgentinaLaboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires 1428, ArgentinaLaboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires 1428, ArgentinaUnidad Operativa Centro de Contención Biológica (UOCCB), Administración Nacional de Laboratorios e Institutos de Salud (ANLIS), Buenos Aires 1282, ArgentinaInstituto de Medicina Traslacional, Trasplante y Bioingeniería (IMETTYB)-CONICET, Buenos Aires 1093, ArgentinaLaboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires 1428, ArgentinaConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires 1425, ArgentinaConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires 1425, ArgentinaLaboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires 1428, ArgentinaLaboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires 1428, ArgentinaNew antiviral treatments are needed to deal with the unpredictable emergence of viruses. Furthermore, vaccines and antivirals are only available for just a few viral infections, and antiviral drug resistance is an increasing concern. Cyanidin (a natural product also called A18), a key flavonoid that is present in red berries and other fruits, attenuates the development of several diseases, through its anti-inflammatory effects. Regarding its mechanism of action, A18 was identified as an IL-17A inhibitor, resulting in the attenuation of IL-17A signaling and associated diseases in mice. Importantly, A18 also inhibits the NF-κB signaling pathway in different cell types and conditions in vitro and in vivo. In this study, we report that A18 restricts RSV, HSV-1, canine coronavirus, and SARS-CoV-2 multiplication, indicating a broad-spectrum antiviral activity. We also found that A18 can control cytokine and NF-κB induction in RSV-infected cells independently of its antiviral activity. Furthermore, in mice infected with RSV, A18 not only significantly reduces viral titers in the lungs, but also diminishes lung injury. Thus, these results provide evidence that A18 could be used as a broad-spectrum antiviral and may contribute to the development of novel therapeutic targets to control these viral infections and pathogenesis.https://www.mdpi.com/1999-4915/15/4/989SARS-CoV-2antiviralimmunomodulatorycyanidinA18broad-spectrum |
| spellingShingle | Josefina Vicente Martina Benedetti Paula Martelliti Luciana Vázquez María Virginia Gentilini Freddy Armando Peñaranda Figueredo Mercedes Soledad Nabaes Jodar Mariana Viegas Andrea Alejandra Barquero Carlos Alberto Bueno The Flavonoid Cyanidin Shows Immunomodulatory and Broad-Spectrum Antiviral Properties, Including SARS-CoV-2 Viruses SARS-CoV-2 antiviral immunomodulatory cyanidin A18 broad-spectrum |
| title | The Flavonoid Cyanidin Shows Immunomodulatory and Broad-Spectrum Antiviral Properties, Including SARS-CoV-2 |
| title_full | The Flavonoid Cyanidin Shows Immunomodulatory and Broad-Spectrum Antiviral Properties, Including SARS-CoV-2 |
| title_fullStr | The Flavonoid Cyanidin Shows Immunomodulatory and Broad-Spectrum Antiviral Properties, Including SARS-CoV-2 |
| title_full_unstemmed | The Flavonoid Cyanidin Shows Immunomodulatory and Broad-Spectrum Antiviral Properties, Including SARS-CoV-2 |
| title_short | The Flavonoid Cyanidin Shows Immunomodulatory and Broad-Spectrum Antiviral Properties, Including SARS-CoV-2 |
| title_sort | flavonoid cyanidin shows immunomodulatory and broad spectrum antiviral properties including sars cov 2 |
| topic | SARS-CoV-2 antiviral immunomodulatory cyanidin A18 broad-spectrum |
| url | https://www.mdpi.com/1999-4915/15/4/989 |
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