The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
Short-chain fatty acids (SCFAs), the end products of fermentation of dietary fibers by the anaerobic intestinal microbiota, have been shown to exert multiple beneficial effects on mammalian energy metabolism. The mechanisms underlying these effects are the subject of intensive research and encompass...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-09-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520351245 |
| _version_ | 1819077175399153664 |
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| author | Gijs den Besten Karen van Eunen Albert K. Groen Koen Venema Dirk-Jan Reijngoud Barbara M. Bakker |
| author_facet | Gijs den Besten Karen van Eunen Albert K. Groen Koen Venema Dirk-Jan Reijngoud Barbara M. Bakker |
| author_sort | Gijs den Besten |
| collection | DOAJ |
| description | Short-chain fatty acids (SCFAs), the end products of fermentation of dietary fibers by the anaerobic intestinal microbiota, have been shown to exert multiple beneficial effects on mammalian energy metabolism. The mechanisms underlying these effects are the subject of intensive research and encompass the complex interplay between diet, gut microbiota, and host energy metabolism. This review summarizes the role of SCFAs in host energy metabolism, starting from the production by the gut microbiota to the uptake by the host and ending with the effects on host metabolism. There are interesting leads on the underlying molecular mechanisms, but there are also many apparently contradictory results. A coherent understanding of the multilevel network in which SCFAs exert their effects is hampered by the lack of quantitative data on actual fluxes of SCFAs and metabolic processes regulated by SCFAs. In this review we address questions that, when answered, will bring us a great step forward in elucidating the role of SCFAs in mammalian energy metabolism. |
| first_indexed | 2024-12-21T18:53:01Z |
| format | Article |
| id | doaj.art-691e7e2ca3194b07a9a3b6aa635bf05d |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-21T18:53:01Z |
| publishDate | 2013-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-691e7e2ca3194b07a9a3b6aa635bf05d2022-12-21T18:53:41ZengElsevierJournal of Lipid Research0022-22752013-09-0154923252340The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolismGijs den Besten0Karen van Eunen1Albert K. Groen2Koen Venema3Dirk-Jan Reijngoud4Barbara M. Bakker5Center for Liver, Digestive, and Metabolic Diseases, Department of Pediatrics and University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Netherlands Consortium for Systems Biology, Amsterdam, The NetherlandsCenter for Liver, Digestive, and Metabolic Diseases, Department of Pediatrics and University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Netherlands Consortium for Systems Biology, Amsterdam, The NetherlandsCenter for Liver, Digestive, and Metabolic Diseases, Department of Pediatrics and University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsNetherlands Consortium for Systems Biology, Amsterdam, The Netherlands; TNO, Zeist, The NetherlandsCenter for Liver, Digestive, and Metabolic Diseases, Department of Pediatrics and University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsTo whom correspondence should be addressed; Center for Liver, Digestive, and Metabolic Diseases, Department of Pediatrics and University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Netherlands Consortium for Systems Biology, Amsterdam, The NetherlandsShort-chain fatty acids (SCFAs), the end products of fermentation of dietary fibers by the anaerobic intestinal microbiota, have been shown to exert multiple beneficial effects on mammalian energy metabolism. The mechanisms underlying these effects are the subject of intensive research and encompass the complex interplay between diet, gut microbiota, and host energy metabolism. This review summarizes the role of SCFAs in host energy metabolism, starting from the production by the gut microbiota to the uptake by the host and ending with the effects on host metabolism. There are interesting leads on the underlying molecular mechanisms, but there are also many apparently contradictory results. A coherent understanding of the multilevel network in which SCFAs exert their effects is hampered by the lack of quantitative data on actual fluxes of SCFAs and metabolic processes regulated by SCFAs. In this review we address questions that, when answered, will bring us a great step forward in elucidating the role of SCFAs in mammalian energy metabolism.http://www.sciencedirect.com/science/article/pii/S0022227520351245nutritional fiberbacterial short-chain fatty acid metabolismshort-chain fatty acid fluxes and concentrations |
| spellingShingle | Gijs den Besten Karen van Eunen Albert K. Groen Koen Venema Dirk-Jan Reijngoud Barbara M. Bakker The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism Journal of Lipid Research nutritional fiber bacterial short-chain fatty acid metabolism short-chain fatty acid fluxes and concentrations |
| title | The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism |
| title_full | The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism |
| title_fullStr | The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism |
| title_full_unstemmed | The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism |
| title_short | The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism |
| title_sort | role of short chain fatty acids in the interplay between diet gut microbiota and host energy metabolism |
| topic | nutritional fiber bacterial short-chain fatty acid metabolism short-chain fatty acid fluxes and concentrations |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520351245 |
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