Homoarginine and creatine deficiency do not exacerbate murine ischaemic heart failure

Homoarginine and creatine deficiency do not exacerbate murine ischaemic heart failure

Abstract Aims Low levels of homoarginine and creatine are associated with heart failure severity in humans, but it is unclear to what extent they contribute to pathophysiology. Both are synthesized via L‐arginine:glycine amidinotransferase (AGAT), such that AGAT−/− mice have a combined creatine and...

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Bibliographic Details
Main Authors: Debra J. McAndrew, Hannah A. Lake, Sevasti Zervou, Edzard Schwedhelm, Jurgen E. Schneider, Stefan Neubauer, Craig A. Lygate
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:ESC Heart Failure
Subjects:
Homoarginine
Creatine
Ventricular function
Heart failure
Myocardial infarction
Animal models
Online Access:https://doi.org/10.1002/ehf2.14183

Internet

https://doi.org/10.1002/ehf2.14183

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