Optimization of amino acid-stabilized erythropoietin parenteral formulation: In vitro and in vivo assessment

Optimization of amino acid-stabilized erythropoietin parenteral formulation: In vitro and in vivo assessment

The aim of this study was to optimize the formulation of erythropoietin (EPO) using amino acids instead of human serum albumin (HSA) and to evaluate its in vivo stability in order to avoid the risk of viral contamination and antigenicity. Different EPO formulations were developed in such a way as to...

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Bibliographic Details
Main Authors: Fayed Bahgat E., Tawfik Abdulkader F., Yassin Alaa Eldeen B.
Format: Article
Language:English
Published: Sciendo 2016-03-01
Series:Acta Pharmaceutica
Subjects:
erythropoietin (epo)
amino acids
human serum albumin
protein stability
bradford
elisa
gel electrophoresis
Online Access:https://doi.org/10.1515/acph-2016-0007

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