Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis

Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis

Abstract Ferroptosis is an iron- and reactive oxygen species (ROS)-dependent form of regulated cell death, that has been implicated in Alzheimer’s disease and Parkinson’s disease. Inhibition of cystine/glutamate antiporter could lead to mitochondrial fragmentation, mitochondrial calcium ([Ca2+]m) ov...

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Bibliographic Details
Main Authors: Alejandro Marmolejo-Garza, Inge E. Krabbendam, Minh Danh Anh Luu, Famke Brouwer, Marina Trombetta-Lima, Osman Unal, Shane J. O’Connor, Naďa Majerníková, Carolina R. S. Elzinga, Cristina Mammucari, Martina Schmidt, Muniswamy Madesh, Erik Boddeke, Amalia M. Dolga
Format: Article
Language:English
Published: Nature Publishing Group 2023-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06290-1

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