Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition Era
Peptides are at the cutting edge of contemporary research for new potent, selective, and safe therapeutical agents. Their rise has reshaped the pharmaceutical landscape, providing solutions to challenges that traditional small molecules often cannot address. A wide variety of natural and modified pe...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/20/7165 |
| _version_ | 1797572775375798272 |
|---|---|
| author | Giacomo Rossino Emanuela Marchese Giovanni Galli Francesca Verde Matteo Finizio Massimo Serra Pasquale Linciano Simona Collina |
| author_facet | Giacomo Rossino Emanuela Marchese Giovanni Galli Francesca Verde Matteo Finizio Massimo Serra Pasquale Linciano Simona Collina |
| author_sort | Giacomo Rossino |
| collection | DOAJ |
| description | Peptides are at the cutting edge of contemporary research for new potent, selective, and safe therapeutical agents. Their rise has reshaped the pharmaceutical landscape, providing solutions to challenges that traditional small molecules often cannot address. A wide variety of natural and modified peptides have been obtained and studied, and many others are advancing in clinical trials, covering multiple therapeutic areas. As the demand for peptide-based therapies grows, so does the need for sustainable and environmentally friendly synthesis methods. Traditional peptide synthesis, while effective, often involves environmentally draining processes, generating significant waste and consuming vast resources. The integration of green chemistry offers sustainable alternatives, prioritizing eco-friendly processes, waste reduction, and energy conservation. This review delves into the transformative potential of applying green chemistry principles to peptide synthesis by discussing relevant examples of the application of such approaches to the production of active pharmaceutical ingredients (APIs) with a peptide structure and how these efforts are critical for an effective green transition era in the pharmaceutical field. |
| first_indexed | 2024-03-10T21:00:40Z |
| format | Article |
| id | doaj.art-69202c2a329546f7aaa829e4174d2326 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T21:00:40Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-69202c2a329546f7aaa829e4174d23262023-11-19T17:33:42ZengMDPI AGMolecules1420-30492023-10-012820716510.3390/molecules28207165Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition EraGiacomo Rossino0Emanuela Marchese1Giovanni Galli2Francesca Verde3Matteo Finizio4Massimo Serra5Pasquale Linciano6Simona Collina7Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyPeptides are at the cutting edge of contemporary research for new potent, selective, and safe therapeutical agents. Their rise has reshaped the pharmaceutical landscape, providing solutions to challenges that traditional small molecules often cannot address. A wide variety of natural and modified peptides have been obtained and studied, and many others are advancing in clinical trials, covering multiple therapeutic areas. As the demand for peptide-based therapies grows, so does the need for sustainable and environmentally friendly synthesis methods. Traditional peptide synthesis, while effective, often involves environmentally draining processes, generating significant waste and consuming vast resources. The integration of green chemistry offers sustainable alternatives, prioritizing eco-friendly processes, waste reduction, and energy conservation. This review delves into the transformative potential of applying green chemistry principles to peptide synthesis by discussing relevant examples of the application of such approaches to the production of active pharmaceutical ingredients (APIs) with a peptide structure and how these efforts are critical for an effective green transition era in the pharmaceutical field.https://www.mdpi.com/1420-3049/28/20/7165peptide therapeuticsantimicrobialsantiviralsanticancerspeptide synthesisgreen chemistry |
| spellingShingle | Giacomo Rossino Emanuela Marchese Giovanni Galli Francesca Verde Matteo Finizio Massimo Serra Pasquale Linciano Simona Collina Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition Era Molecules peptide therapeutics antimicrobials antivirals anticancers peptide synthesis green chemistry |
| title | Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition Era |
| title_full | Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition Era |
| title_fullStr | Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition Era |
| title_full_unstemmed | Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition Era |
| title_short | Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition Era |
| title_sort | peptides as therapeutic agents challenges and opportunities in the green transition era |
| topic | peptide therapeutics antimicrobials antivirals anticancers peptide synthesis green chemistry |
| url | https://www.mdpi.com/1420-3049/28/20/7165 |
| work_keys_str_mv | AT giacomorossino peptidesastherapeuticagentschallengesandopportunitiesinthegreentransitionera AT emanuelamarchese peptidesastherapeuticagentschallengesandopportunitiesinthegreentransitionera AT giovannigalli peptidesastherapeuticagentschallengesandopportunitiesinthegreentransitionera AT francescaverde peptidesastherapeuticagentschallengesandopportunitiesinthegreentransitionera AT matteofinizio peptidesastherapeuticagentschallengesandopportunitiesinthegreentransitionera AT massimoserra peptidesastherapeuticagentschallengesandopportunitiesinthegreentransitionera AT pasqualelinciano peptidesastherapeuticagentschallengesandopportunitiesinthegreentransitionera AT simonacollina peptidesastherapeuticagentschallengesandopportunitiesinthegreentransitionera |