CREB Is Indispensable to KIT Function in Human Skin Mast Cells—A Positive Feedback Loop between CREB and KIT Orchestrates Skin Mast Cell Fate

CREB Is Indispensable to KIT Function in Human Skin Mast Cells—A Positive Feedback Loop between CREB and KIT Orchestrates Skin Mast Cell Fate

Skin mast cells (MCs) are critical effector cells in acute allergic reactions, and they contribute to chronic dermatoses like urticaria and atopic and contact dermatitis. KIT represents the cells‘ crucial receptor tyrosine kinase, which orchestrates proliferation, survival, and functional programs t...

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Bibliographic Details
Main Authors: Gürkan Bal, Jean Schneikert, Zhuoran Li, Kristin Franke, Shiva Raj Tripathi, Torsten Zuberbier, Magda Babina
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
mast cells
skin
transcription factors
CREB
SCF
KIT
Online Access:https://www.mdpi.com/2073-4409/13/1/42

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