Using Discrete Multiphysics Modelling to Assess the Effect of Calcification on Hemodynamic and Mechanical Deformation of Aortic Valve
This study proposes a 3D particle-based (discrete) multiphysics approach for modelling calcification in the aortic valve. Different stages of calcification (from mild to severe) were simulated, and their effects on the cardiac output were assessed. The cardiac flow rate decreases with the level of c...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-08-01
|
| Series: | ChemEngineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-7084/4/3/48 |
| _version_ | 1797560470459121664 |
|---|---|
| author | Adamu Musa Mohammed Mostapha Ariane Alessio Alexiadis |
| author_facet | Adamu Musa Mohammed Mostapha Ariane Alessio Alexiadis |
| author_sort | Adamu Musa Mohammed |
| collection | DOAJ |
| description | This study proposes a 3D particle-based (discrete) multiphysics approach for modelling calcification in the aortic valve. Different stages of calcification (from mild to severe) were simulated, and their effects on the cardiac output were assessed. The cardiac flow rate decreases with the level of calcification. In particular, there is a critical level of calcification below which the flow rate decreases dramatically. Mechanical stress on the membrane is also calculated. The results show that, as calcification progresses, spots of high mechanical stress appear. Firstly, they concentrate in the regions connecting two leaflets; when severe calcification is reached, then they extend to the area at the basis of the valve. |
| first_indexed | 2024-03-10T18:00:01Z |
| format | Article |
| id | doaj.art-6921c1d6433c4d3da3993734c2b91cf3 |
| institution | Directory Open Access Journal |
| issn | 2305-7084 |
| language | English |
| last_indexed | 2024-03-10T18:00:01Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | ChemEngineering |
| spelling | doaj.art-6921c1d6433c4d3da3993734c2b91cf32023-11-20T08:54:43ZengMDPI AGChemEngineering2305-70842020-08-01434810.3390/chemengineering4030048Using Discrete Multiphysics Modelling to Assess the Effect of Calcification on Hemodynamic and Mechanical Deformation of Aortic ValveAdamu Musa Mohammed0Mostapha Ariane1Alessio Alexiadis2School of Chemical Engineering, University of Birmingham, Birmingham B15 2TT, UKDepartment of Materials and Engineering, Sayens—University of Burgundy, 21000 Dijon, FranceSchool of Chemical Engineering, University of Birmingham, Birmingham B15 2TT, UKThis study proposes a 3D particle-based (discrete) multiphysics approach for modelling calcification in the aortic valve. Different stages of calcification (from mild to severe) were simulated, and their effects on the cardiac output were assessed. The cardiac flow rate decreases with the level of calcification. In particular, there is a critical level of calcification below which the flow rate decreases dramatically. Mechanical stress on the membrane is also calculated. The results show that, as calcification progresses, spots of high mechanical stress appear. Firstly, they concentrate in the regions connecting two leaflets; when severe calcification is reached, then they extend to the area at the basis of the valve.https://www.mdpi.com/2305-7084/4/3/48discrete multiphysics modellingsmoothed particle hydrodynamicslattice spring modelparticle-based methodaortic valvecalcification |
| spellingShingle | Adamu Musa Mohammed Mostapha Ariane Alessio Alexiadis Using Discrete Multiphysics Modelling to Assess the Effect of Calcification on Hemodynamic and Mechanical Deformation of Aortic Valve ChemEngineering discrete multiphysics modelling smoothed particle hydrodynamics lattice spring model particle-based method aortic valve calcification |
| title | Using Discrete Multiphysics Modelling to Assess the Effect of Calcification on Hemodynamic and Mechanical Deformation of Aortic Valve |
| title_full | Using Discrete Multiphysics Modelling to Assess the Effect of Calcification on Hemodynamic and Mechanical Deformation of Aortic Valve |
| title_fullStr | Using Discrete Multiphysics Modelling to Assess the Effect of Calcification on Hemodynamic and Mechanical Deformation of Aortic Valve |
| title_full_unstemmed | Using Discrete Multiphysics Modelling to Assess the Effect of Calcification on Hemodynamic and Mechanical Deformation of Aortic Valve |
| title_short | Using Discrete Multiphysics Modelling to Assess the Effect of Calcification on Hemodynamic and Mechanical Deformation of Aortic Valve |
| title_sort | using discrete multiphysics modelling to assess the effect of calcification on hemodynamic and mechanical deformation of aortic valve |
| topic | discrete multiphysics modelling smoothed particle hydrodynamics lattice spring model particle-based method aortic valve calcification |
| url | https://www.mdpi.com/2305-7084/4/3/48 |
| work_keys_str_mv | AT adamumusamohammed usingdiscretemultiphysicsmodellingtoassesstheeffectofcalcificationonhemodynamicandmechanicaldeformationofaorticvalve AT mostaphaariane usingdiscretemultiphysicsmodellingtoassesstheeffectofcalcificationonhemodynamicandmechanicaldeformationofaorticvalve AT alessioalexiadis usingdiscretemultiphysicsmodellingtoassesstheeffectofcalcificationonhemodynamicandmechanicaldeformationofaorticvalve |