Auditory cortex conveys non-topographic sound localization signals to visual cortex
Abstract Spatiotemporally congruent sensory stimuli are fused into a unified percept. The auditory cortex (AC) sends projections to the primary visual cortex (V1), which could provide signals for binding spatially corresponding audio-visual stimuli. However, whether AC inputs in V1 encode sound loca...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-47546-4 |
| _version_ | 1827284224306053120 |
|---|---|
| author | Camille Mazo Margarida Baeta Leopoldo Petreanu |
| author_facet | Camille Mazo Margarida Baeta Leopoldo Petreanu |
| author_sort | Camille Mazo |
| collection | DOAJ |
| description | Abstract Spatiotemporally congruent sensory stimuli are fused into a unified percept. The auditory cortex (AC) sends projections to the primary visual cortex (V1), which could provide signals for binding spatially corresponding audio-visual stimuli. However, whether AC inputs in V1 encode sound location remains unknown. Using two-photon axonal calcium imaging and a speaker array, we measured the auditory spatial information transmitted from AC to layer 1 of V1. AC conveys information about the location of ipsilateral and contralateral sound sources to V1. Sound location could be accurately decoded by sampling AC axons in V1, providing a substrate for making location-specific audiovisual associations. However, AC inputs were not retinotopically arranged in V1, and audio-visual modulations of V1 neurons did not depend on the spatial congruency of the sound and light stimuli. The non-topographic sound localization signals provided by AC might allow the association of specific audiovisual spatial patterns in V1 neurons. |
| first_indexed | 2024-04-24T09:51:04Z |
| format | Article |
| id | doaj.art-6921eecb9e484f3ab65266988e0b68cf |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-24T09:51:04Z |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6921eecb9e484f3ab65266988e0b68cf2024-04-14T11:21:22ZengNature PortfolioNature Communications2041-17232024-04-0115111610.1038/s41467-024-47546-4Auditory cortex conveys non-topographic sound localization signals to visual cortexCamille Mazo0Margarida Baeta1Leopoldo Petreanu2Champalimaud Neuroscience Programme, Champalimaud FoundationChampalimaud Neuroscience Programme, Champalimaud FoundationChampalimaud Neuroscience Programme, Champalimaud FoundationAbstract Spatiotemporally congruent sensory stimuli are fused into a unified percept. The auditory cortex (AC) sends projections to the primary visual cortex (V1), which could provide signals for binding spatially corresponding audio-visual stimuli. However, whether AC inputs in V1 encode sound location remains unknown. Using two-photon axonal calcium imaging and a speaker array, we measured the auditory spatial information transmitted from AC to layer 1 of V1. AC conveys information about the location of ipsilateral and contralateral sound sources to V1. Sound location could be accurately decoded by sampling AC axons in V1, providing a substrate for making location-specific audiovisual associations. However, AC inputs were not retinotopically arranged in V1, and audio-visual modulations of V1 neurons did not depend on the spatial congruency of the sound and light stimuli. The non-topographic sound localization signals provided by AC might allow the association of specific audiovisual spatial patterns in V1 neurons.https://doi.org/10.1038/s41467-024-47546-4 |
| spellingShingle | Camille Mazo Margarida Baeta Leopoldo Petreanu Auditory cortex conveys non-topographic sound localization signals to visual cortex Nature Communications |
| title | Auditory cortex conveys non-topographic sound localization signals to visual cortex |
| title_full | Auditory cortex conveys non-topographic sound localization signals to visual cortex |
| title_fullStr | Auditory cortex conveys non-topographic sound localization signals to visual cortex |
| title_full_unstemmed | Auditory cortex conveys non-topographic sound localization signals to visual cortex |
| title_short | Auditory cortex conveys non-topographic sound localization signals to visual cortex |
| title_sort | auditory cortex conveys non topographic sound localization signals to visual cortex |
| url | https://doi.org/10.1038/s41467-024-47546-4 |
| work_keys_str_mv | AT camillemazo auditorycortexconveysnontopographicsoundlocalizationsignalstovisualcortex AT margaridabaeta auditorycortexconveysnontopographicsoundlocalizationsignalstovisualcortex AT leopoldopetreanu auditorycortexconveysnontopographicsoundlocalizationsignalstovisualcortex |