Emerging applications in mass spectrometry imaging; enablers and roadblocks
Mass spectrometry imaging (MSI) is a powerful and versatile technique able to investigate the spatial distribution of multiple non-labelled endogenous and exogenous analytes simultaneously, within a wide range of samples. Over the last two decades, MSI has found widespread application for an extensi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IM Publications Open
2020-10-01
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| Series: | Journal of Spectral Imaging |
| Subjects: | |
| Online Access: | https://www.impopen.com/download.php?code=I09_a13 |
| _version_ | 1818448775596736512 |
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| author | Cristina Russo Cameron Heaton Lucy Flint Oana Voloaca Sarah Haywood-Small Malcolm Ronald Clench Simona Francese Laura Margaret Cole |
| author_facet | Cristina Russo Cameron Heaton Lucy Flint Oana Voloaca Sarah Haywood-Small Malcolm Ronald Clench Simona Francese Laura Margaret Cole |
| author_sort | Cristina Russo |
| collection | DOAJ |
| description | Mass spectrometry imaging (MSI) is a powerful and versatile technique able to investigate the spatial distribution of multiple non-labelled endogenous and exogenous analytes simultaneously, within a wide range of samples. Over the last two decades, MSI has found widespread application for an extensive range of disciplines including pre-clinical drug discovery, clinical applications and human identification for forensic purposes. Technical advances in both instrumentation and software capabilities have led to a continual increase in the interest in MSI; however, there are still some limitations. In this review, we discuss the emerging applications in MSI that significantly impact three key areas of mass spectrometry (MS) research—clinical, pre-clinical and forensics—and roadblocks to the expansion of use of MSI in these areas. |
| first_indexed | 2024-12-14T20:24:52Z |
| format | Article |
| id | doaj.art-69239562e3cc4a8ab59507a5789d9dc0 |
| institution | Directory Open Access Journal |
| issn | 2040-4565 2040-4565 |
| language | English |
| last_indexed | 2024-12-14T20:24:52Z |
| publishDate | 2020-10-01 |
| publisher | IM Publications Open |
| record_format | Article |
| series | Journal of Spectral Imaging |
| spelling | doaj.art-69239562e3cc4a8ab59507a5789d9dc02022-12-21T22:48:38ZengIM Publications OpenJournal of Spectral Imaging2040-45652040-45652020-10-0191a1310.1255/jsi.2020.a13Emerging applications in mass spectrometry imaging; enablers and roadblocksCristina Russo0https://orcid.org/0000-0002-9776-8897Cameron Heaton1https://orcid.org/0000-0002-4479-3861Lucy Flint2https://orcid.org/0000-0001-6187-3081Oana Voloaca3https://orcid.org/0000-0003-0131-6907Sarah Haywood-Small4https://orcid.org/0000-0002-8374-9783Malcolm Ronald Clench5https://orcid.org/0000-0002-0798-831XSimona Francese6https://orcid.org/0000-0002-1381-1262Laura Margaret Cole7https://orcid.org/0000-0002-2538-6291Middlesex University, The Burroughs, Hendon, London NW4 4BT, UKSheffield Hallam University, Howard St, Sheffield, S1 1WB, UKSheffield Hallam University, Howard St, Sheffield, S1 1WB, UKSheffield Hallam University, Howard St, Sheffield, S1 1WB, UKSheffield Hallam University, Howard St, Sheffield, S1 1WB, UKSheffield Hallam University, Howard St, Sheffield, S1 1WB, UKSheffield Hallam University, Howard St, Sheffield, S1 1WB, UKSheffield Hallam University, Howard St, Sheffield, S1 1WB, UKMass spectrometry imaging (MSI) is a powerful and versatile technique able to investigate the spatial distribution of multiple non-labelled endogenous and exogenous analytes simultaneously, within a wide range of samples. Over the last two decades, MSI has found widespread application for an extensive range of disciplines including pre-clinical drug discovery, clinical applications and human identification for forensic purposes. Technical advances in both instrumentation and software capabilities have led to a continual increase in the interest in MSI; however, there are still some limitations. In this review, we discuss the emerging applications in MSI that significantly impact three key areas of mass spectrometry (MS) research—clinical, pre-clinical and forensics—and roadblocks to the expansion of use of MSI in these areas.https://www.impopen.com/download.php?code=I09_a13mass spectrometry imaging (maldi)secondary ionisation mass spectrometry (sims)desorption electrospray ionisation (desi)laser ablation inductively coupled plasma (la-icp)liquid extraction surface analysis (lesa)imaging mass cytometry (imc)biomolecular imagingtechnical advancementsimaging software |
| spellingShingle | Cristina Russo Cameron Heaton Lucy Flint Oana Voloaca Sarah Haywood-Small Malcolm Ronald Clench Simona Francese Laura Margaret Cole Emerging applications in mass spectrometry imaging; enablers and roadblocks Journal of Spectral Imaging mass spectrometry imaging (maldi) secondary ionisation mass spectrometry (sims) desorption electrospray ionisation (desi) laser ablation inductively coupled plasma (la-icp) liquid extraction surface analysis (lesa) imaging mass cytometry (imc) biomolecular imaging technical advancements imaging software |
| title | Emerging applications in mass spectrometry imaging; enablers and roadblocks |
| title_full | Emerging applications in mass spectrometry imaging; enablers and roadblocks |
| title_fullStr | Emerging applications in mass spectrometry imaging; enablers and roadblocks |
| title_full_unstemmed | Emerging applications in mass spectrometry imaging; enablers and roadblocks |
| title_short | Emerging applications in mass spectrometry imaging; enablers and roadblocks |
| title_sort | emerging applications in mass spectrometry imaging enablers and roadblocks |
| topic | mass spectrometry imaging (maldi) secondary ionisation mass spectrometry (sims) desorption electrospray ionisation (desi) laser ablation inductively coupled plasma (la-icp) liquid extraction surface analysis (lesa) imaging mass cytometry (imc) biomolecular imaging technical advancements imaging software |
| url | https://www.impopen.com/download.php?code=I09_a13 |
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